中文关键词:离子液体咪唑[1,5-a]吡啶鎓抗菌性 英文关键词:Ionic liquidImidazo[1,5-a] pyridinium saltsAntibacterial activities 基金项目:四川省科技创新苗子工程项目（2017063）资助

作者	单位	E-mail
赵波	川北医学院基础医学院 南充 637000
赵人杰	川北医学院精神医学系 南充 637000
朱红	川北医学院基础医学院 南充 637000	zhuhongyuxia@163.com

摘要点击次数:801 全文下载次数:0 中文摘要: 通过三组份串联反应合成一系列咪唑[1，5-a]吡啶鎓盐，利用¹H NMR、¹³C NMR、MS以及X射线单晶衍射确定其结构，其中以二乙烯三胺与三乙烯四胺为原料获得预期外的结构。以青霉素作为对照，研究了化合物的抗菌性。结果表明，所合成的化合物对溶壁微球菌和乙型链球菌均有抗菌效果，化合物2的抗菌效果最好；含有杂原子O的化合物3对嗜麦芽单胞菌和肺炎克雷伯氏菌的抗菌能力优于青霉素；联苯桥联的刚性双齿咪唑[1，5-a]吡啶鎓（5）比乙基桥联的柔性双齿咪唑[1，5-a]吡啶鎓（4）的抗菌性更强；化合物6为单齿大π体系芳香环，其抗菌效果较好，而化合物7和8为双齿的大π体系芳香环，其抗菌效果较弱。 英文摘要: Imidazo[1,5-a] pyridinium salts were synthesized via a facile three-component coupling reaction. Their structures were confirmed by ¹H NMR,¹³C NMR, MS and X-ray crystal diffraction analysis. Unexpected structures were obtained using diethylenetriamine and triethylenetetramine as raw materials. The antibacterial properties of the as-synthesized salts were studied by minimal inhibitory concentration (MIC) method using penicillin as a control. The results showed that all the compounds have antibacterial effect on Micrococcus lysococcus and Streptococcus B, and the antibacterial effect of compound 2 was the best. Compound 3 containing heteroatom O has stronger antibacterial activity against Maltophilia maltophilia and Klebsiella pneumoniae than that of penicillin. The biphenyl bridged bidentate imidazole[1,5-a]pyridinium salt (compound 5) has a better antibacterial effect than the ethyl bridged bidentate imidazole[1,5-a]pyridinium salt (compound 4). Compound 6 having a monodentate large π system aromatic ring has better antibacterial effect than that of compounds 7 and 8 containing a bidentate large π system aromatic ring. 查看全文查看/发表评论下载PDF阅读器 相关附件：附件1版权转让声明书附件1附件2附件3附件1 -->