中文关键词:轴手性硫脲 双功能 1,4-二硫-2,5-二醇 α,β-不饱和酮 英文关键词:axonal thiourea, bifunctional, 1,4-disulfo-2,5-diol, α,β- unsaturated ketone 基金项目:国家自然科学基金项目

作者	单位	E-mail
李淼	贵州师范大学	1184437196@qq.com
陈平平	贵州师范大学
陈治明	贵州师范大学	czm000219@163.com

摘要点击次数:1137 全文下载次数:0 中文摘要: 本文成功合成了3种多氢键轴手性联萘酚硫脲催化剂，并将其应用于1,4-二硫-2,5-二醇和α,β-不饱和酮Sulfa-Michael/Aldol反应，实现了螺[四氢噻吩-3-醇]类化合物的不对称合成，并且对反应条件进行了优化。结果表明：在25 ℃下，THF作为溶剂，20mmol%1a作为催化剂，反应8h，得到较高的产率(92%)，较好的立体选择性(95%)和非对映选择性(﹥90:10 dr)。 英文摘要: In this paper,three kinds of multi-hydrogen bond-axis chiral naphthol thiourea catalysts were successfully synthesized and used to catalyze the Sulfa-Michael/Aldol reaction of 1,4-dithio-2,5-diol and α,β-unsaturated ketone, This type of reaction successfully synthesized spiro[tetrahydrothiophene-3-ol] compounds and optimized the reaction conditions. It is demonstrated that using THF as solvent，the dosage of catalyst is 20mmol%，the temperature and time of reaction are 25 ℃ and 8h,the target products can be obtained with higher yield (up to 92%),better stereoselectivity(up to 86%) and diastereoselectivity(﹥90:10 dr). 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书附件1 -->