中文关键词:烯酰胺双官能化 Povarov反应不对称催化 四氢喹啉 英文关键词:enamides, difunctionalization, Povarovreaction, asymmetriccatalysis, tetrahydroquinolines 基金项目:

作者	单位	E-mail
马小燕	四川理工学院 化学工程学院 自贡643000	maxy@suse.edu.cn
胡新军	四川理工学院 自贡643000

摘要点击次数:1751 全文下载次数:0 中文摘要: 烯酰胺因其氮活化的碳碳双键在各类含氮化合物的合成中具有潜在应用价值,其中有机催化的α,β-双官能化反应在有效骨架的构建中得到了广泛使用。烯酰胺参与的Povarov反应作为邻位双官能化反应的扩展应用,为4-胺基-1,2,3,4-四氢喹啉的构建提供一条简洁高效的途径。尽管该类反应如此重要,直到最近才开发出几种高效的不对称催化方案,本文将对这些研究进展做以总结。 英文摘要: The nitrogen-activated C=C double bonds of enamides have considerable potential for use in the construction of various nitrogen-containing products, and organocatalyzed α,β-difunctionalization of nitrogen-activated double bonds proved to be an efficient and versatile concept, and allowed us to obtain a wide range of useful building blocks. The Povarov reaction with enamides, an extended method for vicinal difunctionalization, provides a straightforward and modular entry to 4-amino-1,2,3,4-tetrahydroquinolines. Despite its importance, it was only very recently that several highly efficient catalytic asymmetric protocols for this reaction have been developed as summarized in this review. 查看全文查看/发表评论下载PDF阅读器 相关附件：版权转让声明书 -->