Jinke Gu
Shuai Zong
Runyu Guo
Tianya Liu
Maojun Yang
1 Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China;
2 School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Funds: We thank the Tsinghua University Branch of China National Center for Protein Sciences (Beijing) for providing the facility support.
Received Date: 2019-12-01
Rev Recd Date:2019-12-11
Abstract
Abstract
Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons. Copious research has been carried out on this lynchpin of respiration. From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1, scientists have gradually uncovered the mysterious veil of the electron transport chain (ETC). With the discovery of the mammalian respiratory mega complex I2III2IV2, a new perspective emerges in the research field of the ETC. Behind these advances glitters the light of the revolution in both theory and technology. Here, we give a short review about how scientists ‘see’ the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades.Keywords: electron transport chain,
supercomplex organization,
cellular respiration,
structure of respirasome,
cryo-EM,
megacomplex
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