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Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assemb

本站小编 Free考研考试/2022-01-02

Nan Wang1,
Wenyuan Chen2,
Ling Zhu1,
Dongjie Zhu1,
Rui Feng1,
Jialing Wang1,
Bin Zhu2,
Xinzheng Zhang1,
Xiaoqing Chen5,
Xianjie Liu5,
Runbin Yan5,
Dongyao Ni5,
Grace Guoying Zhou5,
Hongrong Liu2,,,
Zihe Rao1,3,4,,,
Xiangxi Wang1,,
1 CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
2 Key Laboratory for Matter Microstructure and Function of Hunan Province, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control, School of Physics and Electronics, Hunan Normal University, Changsha 410081, China;
3 Laboratory of Structural Biology, Tsinghua University, Beijing 100084, China;
4 State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300353, China;
5 ImmVira Co., Ltd, Silver Star Hi-tech Industrial Park, Longhua District, Shenzhen 518116, China
Funds: We thank Xiaojun Huang, Boling Zhu, Tongxin Niu and Deyin Fan for cryo-EM technical supports. The cryo-EM data sets were collected at Center for Biological imaging (CBI), Institute of Biophysics. Work was supported by the Key Programs of the Chinese Academy (KJZD-SW-L05), the Strategic Priority Research Program (XDB29010000), National Key Research and Development Program (2018YFA0900801 and 2017YFC0840300), National Natural Science Foundation of China (31800145 and 81520108019) and National Science Foundation of Hunan Province, China (2019JJ10002). Ling Zhu was sponsored by the Youth Innovation Promotion Association at the Chinese Academy of Science. Xiangxi Wang was supported by Ten Thousand Talent Program and the NSFS Innovative Research Group (No. 81921005).






Abstract



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