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Frequent <i>RNF43</i> mutation contributes to moderate activation of Wnt signaling in co

本站小编 Free考研考试/2022-01-02
Yaqi Li1,2,
Jian Li3,4,
Renjie Wang1,2,
Long Zhang1,2,5,
Guoxiang Fu6,
Xueying Wang3,4,
Yebin Wang3,4,
Chuantao Fang3,4,
Dandan Zhang7,
Duo Du7,
Xiaoji Ma1,2,
Mengxue Pan6,
Qiang Guo6,
Xiaoya Xu6,
Xiang Hu1,2,
Yi Zhou6,
Shaobo Mo1,2,
Huijun Wang3,
Jianjun Gao6,
Shenglin Huang8,
Yun Liu7,
Sanjun Cai1,2,
Guoqiang Hua9,,
Junjie Peng1,2,,
Fa-Xing Yu3,4,
1 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;
2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;
3 Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai 200032, China;
4 Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China;
5 Cancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China;
6 Institute of Radiation Medicine, Fudan University, Shanghai 200032, China;
7 MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China;
8 Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China;
9 Institute of Radiation Medicine and Fudan University Shanghai Cancer Center, Shanghai Medical school, Fudan University, Shanghai 200032, China
Funds: This study is supported by grants from the National Natural Science Foundation of China (81622038, 31571479, and 81772965 to F.X. Y., 31470826 and 31670858 to G. H.), the National key R&D program of China (2018YFA0800304) to F.X. Y., Science and Technology Commission of Shanghai Municipality (19JC1411100 to F.X. Y., 16411966300 to G. H., 16411966300 and 18401933402 to J. P.), Shanghai Municipal Commission of Health and Family Planning (2017BR018 to F.X. Y.) and Shanghai Sailing Program (19YF1409500 to Y. L.). We would like to thank Dr. Kang Chen for proofreading of this manuscript.






Abstract



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