Cell-cell contact-induced gene editing/ activation in mammalian cells using a synNotch-CRISPR/Cas9 s

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Hongxin Huang1,2,
Xin Zhang1,
Jie Lv1,
Hongcheng Yang1,
Xinlong Wang1,
Shufeng Ma1,
Ruoyang Shao1,
Xin Peng1,
Ying Lin1,,
Zhili Rong1,2,3,
1 School of Basic Medical Sciences, Cancer Research Institute, Southern Medical University, Guangzhou 510515, China;
2 Dermatology Hospital, Southern Medical University, Guangzhou 510091, China;
3 Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China
Funds: This work was supported by the National Natural Science Foundation of China (81670093 and 81872511), National Science and Technology Major Project (2018ZX10301101), Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110105005), the Program of Department of Science and Technology of Guangdong Province (2014B020212018), the Natural Science Foundation of Guangdong Province (2017A030310331 and 2018A030313455).

Abstract

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http://www.protein-cell.org/article/exportPdf?id=593a2406-9bc7-4736-b39c-7ed8a70dc314&language=en

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