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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

本站小编 Free考研考试/2022-01-02
Paloma Martinez-Redondo1,
Isabel Guillen-Guillen1,5,
Noah Davidsohn2,3,
Chao Wang1,
Javier Prieto1,
Masakazu Kurita1,
Fumiyuki Hatanaka1,
Cuiqing Zhong1,
Reyna Hernandez-Benitez1,
Tomoaki Hishida1,
Takashi Lezaki1,
Akihisa Sakamoto1,
Amy N. Nemeth1,
Yuriko Hishida1,
Concepcion Rodriguez Esteban1,
Kensaku Shojima1,
Ling Huang4,
Maxim Shokhirev4,
Estrella Nu?ez-Delicado5,
Josep M. Campistol6,
Isabel Guillen-Vicente7,
Elena Rodriguez-I?igo7,
Juan Manuel Lopez-Alcorocho7,
Marta Guillen-Vicente7,
George Church2,3,
Pradeep Reddy1,
Pedro Guillen-Garcia7,
Guang-Hui Liu8,9,10,11,,
Juan Carlos Izpisua Belmonte1,
1 Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA;
2 Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02115, USA;
3 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;
4 Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA;
5 Universidad Católica San Antonio de Murcia(UCAM), Campus de los Jerónimos, No 135 12, 30107 Guadalupe, Spain;
6 Hospital Clinic of Barcelona, Career Villarroel, 170, 08036 Barcelona, Spain;
7 Department of Traumatology and Research Unit, Clinica CEMTRO, 28035 Madrid, Spain;
8 National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
9 University of Chinese Academy of Sciences, Beijing 100049, China 10 Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China 11 Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Funds: This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010100), Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone (ZJ2018-ZD-004), the National Natural Science Foundation of China (81625009, 81330008, 91749202), Beijing Municipal Commission of Health and Family Planning (PXM2018_026283_000002).






Abstract



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