Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch

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Shang-Xiang Ye1,
Zhou Gong2,
Ju Yang2,
Yu-Xin An4,
Zhu Liu2,
Qun Zhao4,
Ewen Lescop3,
Xu Dong2,,
Chun Tang1,2,
1 Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China;
2 CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance at Wuhan, Wuhan Institute of Physics and Mathematics of the Chinese Academy of Sciences, Wuhan 430071, China;
3 Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette cedex, France;
4 CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics of the Chinese Academy of Sciences, Dalian 116023, China

Abstract

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