Qian Li
Hui Li
Yun-Cai Liu
Jee Ho Lee
1 Institute for Immunology, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;
2 La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Funds: This work is supported by funding from MOST YFA0505802, NSFC81630041, NIH RO1AI123398 and R21AI122258.
Received Date: 2018-09-26
Abstract
Abstract
Protein ubiquitination is an important means of posttranslational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress in understanding their roles in the differentiation and function of CD4+ T helper cell subsets, the stability of regulatory T cells, effector function of CD8+ T cells, as well as the development and maturation of innate lymphoid cells. The biological implications of these E3 ubiquitin ligases will be highlighted in the context of normal and dysregulated immune responses including the control of homeostasis, inflammation, auto-immune responses and anti-tumor immunity. Further elucidation of the ubiquitin system in immune cells will help in the design of new therapeutic interventions for human immunological diseases and cancer.Keywords: ubiquitin,
E3 ligase,
VHL,
HIF,
Itch,
WWP2,
Cbl-b,
inflammation,
autoimmunity
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