基本信息
李一叶女硕导国家纳米科学中心
电子邮件： liyy@nanoctr.cn
通信地址： 北京市海淀区中关村北一条11号
邮政编码： 100190
部门/实验室：纳米生物效应与安全性研究室
研究领域

招生信息
招生专业0710J1-纳米科学与技术
071010-生物化学与分子生物学

招生方向纳米生物医学
纳米生物效应
胰腺癌治疗


教育背景
学历
学位

工作经历
工作简历2019-03~现在,国家纳米科学中心,研究员
2015-03~2019-03,国家纳米科学中心,副研究员

社会兼职

教授课程纳米生物材料


专利与奖励
奖励信息
专利成果（ 1 ） 人颗粒酶B 蛋白衍生物及其在靶向治疗腺癌中的用途, 2013, 第 2 作者, 专利号: ZL 6.X
（ 2 ） 一种靶向性杂化纳米体系及其制备方法和应用, 2017, 第 3 作者, 专利号: 8.3
（ 3 ） 一种IDO1 多肽纳米抑制剂及其制备方法和应用, 2018, 第 3 作者, 专利号: 1.6
（ 4 ） 一种纳米粒子及其制备方法和用途, 2019, 第 3 作者, 专利号: 5.5


出版信息
发表论文（1）Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors,Biomaterials,2020-02,第11作者
（2）Modularly Designed Peptide Nanoprodrug Augments Anti-Tumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2, 3-Dioxygenase,Journal of the American Chemical Society,2020-02,第11作者
（3）Plasmon-Enhanced Oxidase-Like Activity and Cellular Effect of Pd-Coated Gold Nanorods,ACS Applied Materials & Interfaces,2019-11,第2作者
（4）Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity,ACS NANO,2019-10,第11作者
（5）Synthesis and Imaging of Biocompatible Graphdiyne Quantum Dots,ACS Applied Materials & Interfaces,2019-08,第11作者
（6）Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air–Liquid Interface,Environmental Science & Technology,2019-07,第6作者
（7）An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy,ACS NANO,2019-03,第11作者
（8）Biomimetic Metal-Organic Framework Nanoparticles for Cooperatively Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy,Advanced Materials,2019-02,第11作者
（9）Precise Design of Nanomedicines: Perspectives for Cancer Treatment,National Science Review,2019-02,第1作者
（10）Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth,ACS NANO,2019-01,第5作者
（11）Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem,Nature Communications,2018,第11作者
（12）Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine Affect Cellular Energy Metabolism,Angewandte Chemie International Edition,2018,第1作者
（13）Nanomaterial Libraries and Model Organisms for Rapid High Content Analysis of Nanosafety,National Science Review,2018,第1作者
（14）Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod.,ACS Nano,2017,第11作者
（15）Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis.,Theranostics,2017,第9作者
（16）Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures,Biomaterials,2017,第7作者
（17）Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triplenegative breast cancer,Biomaterials,2016,第3作者
（18）Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy,Nanomedicine: Nanotechnology, Biology, and Medicine,2016,第11作者
（19）An MMP?2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer,ACS Applied Materials & Interfaces,2016,第8作者
（20）Analytical methods for nano-bio interface interactions,Science China-Chemistry,2016,第3作者
（21）Triple-punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug Dosage and Improved Antitumor Efficacy,ACS NANO,2015,第1作者
（22）Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer,Biomaterials,2015,第1作者
（23）Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy, ACS Nano,2014,第1作者
（24）Cellular uptake and distribution of graphene oxide coated with layer-by-layer assembled polyelectrolytes, Journal of Nanoparticle Research,2014,第1作者
（25）Antineoplastic activities of Gd@C82(OH)22 nanoparticles: tumor microenvironment regulation,Science China-Life Sciences,2012,第1作者
（26）Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation,Small,2012,第2作者
（27）Deciphering an underlying mechanism of differential cellular effects of nanoparticles: An example of Bach-1 dependent induction of HO-1 expression by gold nanorod,Biointerphases,2012,第3作者
（28）Chirality of glutathione surface coating affects the cytotoxicity of quantum dots, Angewandte Chemie International Edition,2011,第1作者

发表著作

科研活动
科研项目（ 1 ） 基于高通量纳米安全性评价系统的金纳米材料构效关系研究, 主持,国家级,2014-01--2016-12
（ 2 ） 基于胰腺星状细胞调控的金纳米药物体系的设计与联合抗肿瘤研究, 主持,国家级,2016-01--2019-12
（ 3 ） 机动车来源的大气超细颗粒物诱发自噬相关生物效应机制研究, 主持,国家级,2016-01--2018-12
（ 4 ） 微环境响应型自组装生物纳米材料的表/界面调控及肿瘤治疗研究, 参与,国家级,2018-07--2023-06

参与会议（1）Enhanced delivery of nanomedicine to desmoplastic pancreatic tumors by restoring the homeostatic stroma2019-08-17
（2）基于胰腺肿瘤微环境的精准纳米研究中国抗癌协会胰腺癌专业委员会年会2017-10-29
（3）光激活纳米体系增强的肿瘤联合治疗纳米生物光子学创新发展专家论坛2017-09-26
（4）Photoactivatable Nanoplatforms Enhanced Combination Cancer Therapy2017-08-29
（5）Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy李一叶2015-03-24


合作情况
项目协作单位

指导学生