基本信息
Andrew Teschendorff男博导中国科学院上海营养与健康研究所
电子邮件： andrew@picb.ac.cn
通信地址： 上海市岳阳路320号
邮政编码：
部门/实验室：计算生物学伙伴研究所
研究领域

招生信息
招生专业0710Z2-计算生物学

招生方向系统基因组学，计算生物学


教育背景
学历
学位

工作经历
工作简历2015-09~现在,University College London, Dept.of Women’s Cancer,Principal Research Associate in Statistical Cancer Genomics
2013-09~现在,中国科学院-马普学会计算生物学伙伴研究所,计算系统基因组学课题组PI
2008-09~现在,University College London, UCL Cancer Institute,Principal Research Associate in Statistical Cancer Genomics (2008-2013). Newton Advanced Fellow (2015–2018).
2003-09~2008-08,University of Cambridge, Department of Oncology,Senior Postdoctoral Fellow in Computational Biology
2001-08~2003-08,University of Warwick, Mathematics Institute,Research Assistant in Mathematical Ecology
2000-07~2001-07,British Telecom Labs, Complexity Research,Member of the Complexity Research Group headed by Dr Sverrir Olafsson.

社会兼职

教授课程

专利与奖励
奖励信息
专利成果

出版信息
发表论文（1）Stochastic epigenetic outliers can define field defects in cancer.,BMC Bioinformatics,2016,第1作者
（2）Epigenetic drift, epigenetic clocks and cancer risk.,Epigenomics,2016,第11作者
（3）Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer.,Epigenetics Chromatin,2016,第11作者
（4）DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer.,Nature Communications,2016,第1作者
（5）The integrative epigenomic-transcriptomic landscape of ER positive breast cancer.,Clin Epigenetics,2015,第11作者
（6）HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer.,Genome Med,2015,第1作者
（7）Variational Bayesian Matrix Factorization for Bounded Support Data.,IEEE Trans Pattern Anal Mach Intell.,2015,第2作者
（8）An integrative pan-cancer wide analysis of epigenetic enzymes reveals universal patterns of epigenetic deregulation in cancer.,Genome Biol,2015,第11作者
（9）Smoking-associated DNA methylation changes in buccal cells correlate with DNA methylation changes in epithelial cancer.,JAMA Oncol,2015,第1作者
（10）Increased signalling entropy in cancer requires the scale-free property of protein interaction networks.,Sci Rep,2015,第1作者
（11）Denoising perturbation signatures reveals an actionable AKT signalling gene module underlying a poor clinical outcome in endocrine treated ER+ breast cancer.,Genome Biol,2015,第1作者
（12）Intra-tumour molecular entropy determines clinical outcome in breast and lung cancer.,PLoS Comput. Biol.,2015,第11作者
（13）An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.,PLoS Genetics,2015,第11作者
（14）Biomedical data integration, modeling, and simulation in the era of big data and translational medicine,Biomed Res Int,2014,第2作者
（15）The dynamics of DNA methylation covariation patterns in carcinogenesis.,PLoS Comput Biol.,2014,第11作者
（16）Comparisons of non-gaussian statistical models in DNA methylation analysis.,Int J Mol Sci.,2014,第2作者
（17）A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies dif- ferential gene expression modules under epigenetic control.,Bioinformatics,2014,第11作者
（18）Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data.,Methods.,2014,第11作者
（19）Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.,PLoS Med,2013,第2作者
（20）Cellular network entropy as the energy potential in Waddington’s differentiation landscape.,Sci Rep.,2013,第11作者
（21）Epigenetic aging: insights from network biology.,Aging (Albany NY),2013,第11作者
（22）The distinctive topology of age-associated epigenetic drift in the human interactome.,Proc Natl Acad Sci USA.,2013,第11作者
（23）Age-associated epigenetic drift: implications, and a case of epigenetic thrift?.,Hum Mol Genet.,2013,第11作者
（24）A variational Bayes Beta Mixture Model for improved clustering and feature selection in DNA methylation studies.,Journal of Bioinformatics and Computational Biology,2013,第11作者
（25）An integrative network algorithm identifies age-associated differential DNA methylation interactome hotspots tar- geting stem cell differentiation pathways.,Sci Rep,2013,第11作者
（26）Identification and functional validation of HPV-mediated hypermethylation in head & neck squamous cell carcinoma.,Genome Medicine,2013,第11作者
（27）A Beta-Mixture Quantile Normalisation method for correcting probe design bias in Illumina Infinium 450k DNA methylation data.,Bioinformatics,2013,第11作者

发表著作

科研活动
科研项目（ 1 ） 癌症系统表观基因组学新型生物信息统计算法研究, 主持,国家级,2016-01--2019-12
（ 2 ） 表观基因组关联分析新型细胞类型去卷积算法研究, 主持,国家级,2018-01--2021-12

参与会议

合作情况
项目协作单位

指导学生