基本信息
万林男博导中国科学院数学与系统科学研究院
电子邮件： lwan@amss.ac.cn
通信地址： 北京市海淀区中关村东路55号
邮政编码： 100190

研究领域

招生信息
招生专业070103-概率论与数理统计
071101-系统理论
071400-统计学

招生方向计算与系统生物学
系统生物学,随机系统
数据科学,生物统计


教育背景2003-09--2009-07北京大学理学博士
1999-09--2003-07南京大学理学学士

学历 -- 研究生

学位 -- 博士


工作经历
工作简历2014-03~现在,中国科学院数学与系统科学研究院,副研究员
2011-08~2014-02,中国科学院数学与系统科学研究院,助理研究员
2009-04~2011-08,中国科学院数学与系统科学研究院,博士后

社会兼职

教授课程系统估计
概率论与数理统计习题课-01
概率论与数理统计
概率论与数理统计习题课-02


专利与奖励
奖励信息（1） Early Career Award, 研究所（学校）, 2016
（2） 关肇直青年研究奖, 研究所（学校）, 2014
（3） 中国科学院数学与系统科学研究院优秀教师奖, 研究所（学校）, 2014

专利成果（ 1 ） 用于多个分子信号的数据处理方法与装置, 发明, 2015, 第 2 作者, 专利号: 8.8


出版信息
发表论文（1）DensityPath: an algorithm to visualize and reconstruct cell state-transition path on density landscape for single-cell RNA sequencing data,Bioinformatics,2019,通讯作者
（2）Statistical test of structured continuous trees based on discordance matrix,Bioinformatics,2019,通讯作者
（3）TSEE: an elastic embedding method to visualize the dynamic gene expression patterns of time series single-cell RNA sequencing data,BMC Genomics,2019,通讯作者
（4）Statistical testing and power analysis for brain-wide association study,Medical Image Analysis,2018,第2作者
（5）A remark on copy number variation detection methods,PLoS ONE,2018,通讯作者
（6）A branch point on differentiation trajectory is the bifurcating event revealed by dynamical network biomarker analysis of single-cell data,IEEE/ACM Transactions on Computational Biology and Bioinformatics,2018,通讯作者
（7）Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis,NeuroImage,2017,第6作者
（8）An adaptive decorrelation method removes Illumina DNA base-calling errors caused by crosstalk between adjacent clusters,Scientific Reports,2017,第2作者
（9）Individual differences in schizophrenia,British Journal of Psychiatry Open,2017,第3作者
（10）Estimating Phred scores of Illumina base calls by logistic regression and sparse modeling,BMC Bioinformatics,2017,第3作者
（11）Individual differences in schizophrenia,British Journal of Psychiatry Open,2017,第3作者
（12）Achieving Accurate and Fast Base-calling by a Block Model of the Illumina Sequencing Data,IFAC-PapersOnLine,2015,第2作者
（13）Tracking the Evolving Spatial-Temporal Gene Networks,IFAC-PapersOnLine,2015,通讯作者
（14）应用全基因组拷贝数变异方法探索参芪膜肾方治疗特发膜性肾病基因水平机制的研究,中国中西医结合肾病杂志,2014,通讯作者
（15）Modeling RNA degradation for RNA-Seq with applications,Biostatistics,2012,第1作者
（16）CEDER: Accurate detection of differentially expressed genes by combining significance of exons using RNA-Seq,IEEE/ACM Transactions on Computational Biology and Bioinformatics,2012,第1作者
（17）Hybridization and amplification rate correction for affymetrix SNP arrays,BMC Medical Genomics,2012,通讯作者
（18）A study of biases of DNA copy number estimation based on PICR model,Frontiers of Mathematics in China,2011,通讯作者
（19）RseqFlow: Workflows for RNA-Seq data analysis,Bioinformatics,2011,第9作者
（20）New powerful statistics for alignment-free sequence comparison under a pattern transfer model,Journal of Theoretical Biology,2011,第1作者
（21）Alignment-free sequence comparison (II): Theoretical power of comparison statistics,Journal of Computational Biology,2010,第1作者
（22）The biases of copy numbers from Affymetrix SNP arrays and their corrections,Communications in Information and Systems,2010,第1作者
（23）Hybridization modeling of oligonucleotide SNP arrays for accurate DNA copy number estimation, Nucleic Acids Research,2009,第1作者
（24）Nonlinear cooperation between p53 and ING1 induces bax expression in mouse thymocyte apoptosis: A quantitative approach with cross-platform validation,Apoptosis,2009,第1作者
（25）Searching for bidirectional promoters in Arabidopsis thaliana,BMC Bioinformatics,2009,第2作者
（26）Conservation and implications of eukaryote transcriptional regulatory regions across multiple species,BMC Genomics,2009,第1作者
（27）Relaxation dynamics and glass transition in glassy materials,Synthetic Metals,2003,第3作者

发表著作

科研活动
科研项目（ 1 ） 动物复杂形状的进化解析与调控, 参与,部委级,2014-07--2019-06
（ 2 ） 中国科学院青年创新促进会, 主持,部委级,2016-01--2019-12
（ 3 ） 生物/医学时空型数据的建模、计算与系统综合研究, 主持,国家级,2016-01--2019-12
（ 4 ） 重大脑精神疾病的遗传影像学分析理论与计算方法, 参与,国家级,2017-01--2019-12

参与会议（1）A branch point on differentiation trajectory is the bifurcating event revealed by dynamic network biomarker analysis of single cell data2017-08-18
（2）The Modelling and Computation of Multi-Mode Biological Data of Mental Disorder2017-07-17
（3）Reconstruction of Dynamical Trajectories of Cells Based on Single-Cell Data12017-07-10
（4）Tracking the Evolving Spatial-Temporal Gene NetworksWeikang Gong, Lin Wan2015-10-19
（5）Identification of the Time-Varying Gene Network for Brain Development with Application to Mental Diseases StudiesLin Wan2015-08-13
（6）CEDER: Accurate detection of differentially expressed genes by combining significance of exons using RNA-SeqLin Wan2012-01-17


合作情况
项目协作单位

指导学生现指导学生
陈紫薇硕士研究生071101-系统理论
安少坤硕士研究生071101-系统理论