基本信息
汪福意男博导中国科学院化学研究所
电子邮件： fuyi.wang@iccas.ac.cn
通信地址： 北京海淀区中关村北一街2号
邮政编码： 100190

研究领域Ø 质谱分析
Ø 化学生物学
Ø 抗肿瘤药物设计和分子作用机理研究


教育背景1994-09--1998-12武汉大学理学博士
1983-07--1988-08华中师范大学理学硕士
1979-10--1983-06华中师范大学理学学士

学历博士

学位1983华中师范大学理学学士
1991华中师范大学理学硕士
1999武汉大学理学博士

出国学习工作2000年1月-2007年1月 英国爱丁堡大学博士后、助理研究员

工作经历
工作简历2006-06~现在,中国科学院化学研究所,研究员
2000-01~2006-12,英国爱丁堡大学,Research Fellow
1991-07~2000-01,华中师范大学,讲师，副教授
1983-07~1988-08,咸宁师范高等专科学校,助教，讲师

社会兼职2012-01-01-今,中国物理学会质谱分会, 常务理事
2012-01-01-今,中国蛋白质组专业委员会, 委员


教授课程分析化学I
高等仪器分析


专利与奖励
奖励信息（1） 中国分析测试协会科学技术奖, 二等奖, 其他, 2014

专利成果（ 1 ） 一种含有钌的配合物及其制备方法, 发明, 2015, 第 1 作者, 专利号: ZL4.1
（ 2 ） 一种酪氨酸蛋白激酶抑制剂及其制备方法, 发明, 2014, 第 1 作者, 专利号: ZL 5.6
（ 3 ） 一种抑制肿瘤细胞增殖的喹唑啉衍生物、喹唑啉配合物蛋白激酶抑制剂及它们的制备方法, 发明, 2016, 第 1 作者, 专利号: US9,233,995B2
（ 4 ） 一种抑制肿瘤细胞增殖的喹唑啉衍生物、喹唑啉配合物蛋白激酶抑制剂及它们的制备方法, 发明, 2015, 第 1 作者, 专利号: JP2013-353272
（ 5 ） 一种抑制肿瘤细胞增殖的喹唑啉衍生物、喹唑啉配合物蛋白激酶抑制剂及它们的制备方法, 发明, 2015, 第 1 作者, 专利号: EP11 835 642.7
（ 6 ） 一种抑制肿瘤细胞增殖的喹唑啉衍生物、喹唑啉配合物蛋白激酶抑制剂及它们的制备方法, 发明, 2017, 第 1 作者, 专利号: GE0.6
（ 7 ） 一种抑制肿瘤细胞增殖的喹唑啉衍生物、喹唑啉配合物蛋白激酶抑制剂及它们的制备方法, 发明, 2017, 第 1 作者, 专利号: EP**-FR
（ 8 ） 一种抑制肿瘤细胞增殖的喹唑啉衍生物、喹唑啉配合物蛋白激酶抑制剂及它们的制备方法, 发明, 2017, 第 1 作者, 专利号: EP**-GB


出版信息


发表论文（1）Multi-Targeted Anticancer Agents (invited review),Current Topics in Medicinal Chemistry,2017,通讯作者
（2）Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging,J. Biol. Inorg. Chem.,2017,通讯作者
（3）Investigations of molecular mechanism of action of metal-based anticancer complexes by mass spectrometry,SCIENTIA SINICA Chimica,2017,通讯作者
（4）Evaluation of serum phosphopeptides as potential biomarkers of gastric cancer,RSC Adv.,2017,通讯作者
（5）Deciphering of Interactions between Platinated DNA and HMGB1 by Hydrogen/Deuterium Exchange Mass Spectrometry,Dalton Trans.,2017,通讯作者
（6）Correlated Q1 Q2 mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex,Chem. Commum.,2017,通讯作者
（7）Probing the Dynamic Interaction between Damaged DNA and a Cellular Responsive Protein Using a Piezoelectric Mass Biosensor,ACS Appl. Mater. Interfaces,2017,通讯作者
（8）In situ Mass Spectrometric Monitoring of the Dynamic Electrochemical Process at the Electrode-Electrolyte Interface: a SIMS Approach,Anal. Chem.,2017,通讯作者
（9）Nanoscale imaging of Li and B in nuclear waste glass, a comparison of ToF-SIMS, NanoSIMS, and APT,Surf. Interface Anal.,2016,通讯作者
（10）A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry,J. Inorg. Biochem.,2016,通讯作者
（11）Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines,Inorg. Chem.,2016,通讯作者
（12）Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes,Sci China Chem,2016,通讯作者
（13）Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells,Metallomics,2015,通讯作者
（14）Argon Cluster Sputtering Source for ToF-SIMS Depth Profiling of Insulating Materials: High Sputter Rate and Accurate Interfacial Information,J. Am. Soc. Mass Spectrom.,2015,通讯作者
（15）Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands,Dalton Trans.,2015,通讯作者
（16）Quantification of Bindings of Organometallic Ruthenium Complexes to GSTπ by Mass Spectrometry,J. Inorg. Biochem.,2015,通讯作者
（17）Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry,Analyst,2014,通讯作者
（18）Biosurfactant produced by Novel Pseudomonas sp. WJ6 with 3 Biodegradation of n-Alkanes and Polycyclic Aromatic Hydrocarbons,J. Hazard. Mater.,2014,通讯作者
（19）ToF-SIMS depth profiling of insulating samples: interlaced mode or non-interlaced mode,Surf. Interface Anal.,2014,通讯作者
（20）Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment,Talanta,,2014,通讯作者
（21）Novel Ruthenium Complexes Ligated with 4-Anilinoquinazoline Derivatives: Synthesis, Characterisation and Preliminary Evaluation of Biological Activity,Eur. J. Med. Chem.,2014,通讯作者
（22）Mass Spectrometric Proteomics Reveals that Nuclear Protein Posi-tive Cofactor PC4 Selectively Binds to Crosslinked DNA by a Trans-platinum Anticancer Complex,J. Am. Chem. Soc.,2014,通讯作者
（23）Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes,Metallomics,2014,通讯作者
（24）De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of A Platinum Anticancer Complex,Angew. Chem. Int. Ed.,2013,通讯作者
（25）Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1,Chem. Commun.,2013,通讯作者
（26）Thymines in single-stranded oligonucleotides and G-quadruplex DNA are competitive with guanines for binding to an organoruthenium anticancer complex,Inorg. Chem.,2013,通讯作者
（27）Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase,J. Inorg. Biochem.,2013,通讯作者
（28）Complexation with Organometallic Ruthenium Pharmacophores Enhances the Ability of 4-Anilinoquinazolines Inducing Apoptosis,Chem. Commun.,2013,通讯作者
（29）Lipophilic thioguanosine: an anion receptor for cesium fluoride,J. Fluorine Chem.,2013,通讯作者
（30）Transferrin serves as a mediator to deliver organometallic ruthenium(II) anticancer complexes into cells,Inorg. Chem.,2013,通讯作者
（31）The role of serum albumin in the metabolism of Boc5: molecular identification, species differences and contribution to plasma metabolism,Eur. J. Pharm. Sci.,2013,通讯作者
（32）Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing vs top-down,J. Am. Soc. Mass Spectrom.,2013,通讯作者
（33）Competition between glutathione and DNA oligonucleotides for ruthenium(II) arene anticancer complexes,Dalton Trans.,2013,第1作者
（34）Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors,Eur. J. Med. Chem.,2013,通讯作者
（35）Quantitative Mass Spectrometry Combined with Separation and Enrichment of Phosphopeptides by Titania Coated Magnetic Mesoporous Silica Microspheres for Screening of Protein Kinase Inhibitors,Anal. Chem.,2012,通讯作者
（36）Mechanism of Interstrand Migration of Organoruthenium Anticancer Complexes within a DNA Duplex,Metallomics,2012,通讯作者
（37）Synthesis and docking study of 2-phenylaminopyrimidine Abl tyrosine kinase inhibitors,Bioorg. Med. Chem. Lett.,2011,通讯作者
（38）reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide - a model for the active-site cysteine of protein tyrosine phosphatase 1B,Dalton Trans.,2011,通讯作者
（39）the anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin,Chem. Commun.,2011,通讯作者
（40）Elucidation of the Binding Sites of Sodium Dodecyl Sulfate to ?-Lactoglobulin Using Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Docking Simulation,Rapid Commun. Mass Spectrom.,2011,通讯作者
（41）A Comparative Study on Interactions of Cisplatin and Ruthenium Arene Anticancer Complexes with Metallothionein using MALDI-TOF-MS,Intl. J. Mass Spectrom.,2011,通讯作者
（42）the formation of thymidine-based t-tetramers with remarkable structural and metal ion size effects,Org. Biomol. Chem.,2011,通讯作者
（43）Inhibitor Screening of Protein Kinases Using MALDI-TOF MS Combined with Separation and Enrichment of Phosphopeptides by TiO2 Nanoparticle Deposited Capillary Column,Analyst,2010,通讯作者
（44）single-molecule behavior of dendritic poly(ethylene glycol) structures towards lithium ions,Chem. Eur. J.,2009,通讯作者
（45）characterization and reaction pathway for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex,J. Biol. Inorg. Chem.,2009,通讯作者
（46）Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes,Chem. Eru. J,2009,通讯作者
（47）identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry,J. Am. Soc. Mass Spectrom.,2008,第1作者
（48）diversity in G-selective DNA binding modes for an organometallic ruthenium arene complex,Angew. Chem. Int. Ed.,2006,第3作者
（49）ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes,CHem. Eur. J.,2006,第2作者
（50）controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity,Proc. Natl. Acad. Sci. U. S. A.,2005,第1作者
（51）competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate.,J. Am. Chem. Soc.,2005,第1作者
（52）competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide,J. Biol. Inorg. Chem.,2005,第1作者
（53）kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts,Chem. Eur. J.,2003,第1作者

发表著作

科研活动
科研项目（ 1 ） 调控蛋白与药物损伤DNA相互作用研究的分析新方法, 主持,国家级,2012-01--2016-12
（ 2 ） 基于利水功效的中药药性理论研究/课题五：性味物质基础的发现与评价方法研究, 主持,国家级,2013-01--2017-12
（ 3 ） 基于化学遗传学的金属抗肿瘤药物分子作用机理研究新方, 主持,国家级,2016-01--2019-12
（ 4 ） 高分辨多功能化学成像系统, 参与,国家级,2012-01--2016-12
（ 5 ） 金属抗肿瘤药物相互作用组学的方法学研究, 主持,国家级,2011-01--2013-12
（ 6 ） LC－MS研究金属抗肿瘤药物与血清蛋白的相互作用, 主持,国家级,2010-01--2012-12

参与会议（1）Discovery and Deciphering of the Recognition between Transplatinated DNA and Nuclear Protein Positive Cofactor PC4 by Mass Spectrometry第七届亚太质谱分析学术报告会2017-12-12
（2）ToF-SIMS和激光共聚焦联用显微成像研究单细胞内顺铂损伤DNA和蛋白质的相互识别第三届全国质谱分析学术报告会2017-12-10
（3）Correlated ToF-SIMS and Confocal Microscopy Imaging Visualizes the Recognition 2017亚洲药学联盟大会2017-11-22
（4）反铂损伤DNA和核蛋白阳性辅助因子PC4相互识别第四届全国化学生物学学术会议2017-09-23
（5）Qualitative and quantitative MS strategies for investigation of interactions between metal-based anticancer complexes and proteins第六届世界华人质谱学术研讨会2016-06-04
（6）ToF-SIMS Imaging Visualizes Subcellular Distribution of Metal Anticancer Complexes2015-10-28
（7）3.Imaging for Visualization of Metal Anticancer Complexes in Single Cells2015-09-12
（8）Time-of-Flight Secondary Ion Mass Spectrometry Imaging for Visualization of Metal Anticancer Complexes in Single Cells2015-07-20
（9）Mass Spectrometric Proteomics for Identification of Cellular Proteins in Response to DNA Damages by Platinum Anticancer Agents第五届亚洲与大洋洲质谱会议暨第33届中国质谱学会学术年会2014-07-16
（10）Mass Spectrometric Proteomics for Identification of Cellular Proteins in Response to DNA Damages by Platinum Anticancer Agents2014第七届国际蛋白质和多肽大会2014-04-25


合作情况
项目协作单位

指导学生已指导学生
吕爽博士研究生070302-分析化学
魏晓奕博士研究生070302-分析化学
姚春荷博士研究生070302-分析化学
吴魁博士研究生070302-分析化学
纪丽云博士研究生070302-分析化学
胡文兵博士研究生070302-分析化学
郑伟博士研究生070302-分析化学
韩玉苗博士研究生070302-分析化学
林煜博士研究生070302-分析化学
郭伟博士研究生070302-分析化学
翟贵金博士研究生070302-分析化学
杜支凤博士研究生070302-分析化学
张扬博士研究生070302-分析化学
刘素彦博士研究生070302-分析化学
梁祖青硕士研究生070302-分析化学
王媛媛博士研究生070302-分析化学
王朝英博士研究生070302-分析化学
梁塑硕士研究生070302-分析化学
现指导学生
张燕燕博士研究生070302-分析化学
戚鲁豫 硕士研究生070302-分析化学
曾文娟博士研究生070302-分析化学
姜懿璇硕士研究生070302-分析化学
侯垠竹 硕士研究生070302-分析化学