姓名：李丽英 性别：女 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：细胞生物学(博) 细胞生物学(硕) 研究方向名称：肝脏损伤修复的细胞学机制 电子信箱：liliying@ccmu.edu.cn


社会任职
1. 北京细胞生物学会理事
个人简历
1. 200510-:首都医科大学基础医学院细胞生物学系 教授
重要学术论文
1. Zhou X#, Yang L#, Fan X#, Zhao X , Chang N, Yang L, Li L*.Neutrophil Chemotaxis and NETosis in Murine Chronic Liver Injury via Cannabinoid Receptor 1/ Gi/o/ ROS/ p38 MAPK Signaling Pathway. Cells. 2020,9(2):E373.SCI
2. Chang N, Duan X, Zhao Z, Tian L, Ji X, Yang L, Li L*.Both HuR and miR-29s regulate expression of CB1 involved in infiltration of bone marrow monocyte/macrophage in chronic liver injury. J Cell Physiol. 2020,235(3):2532-2544.SCI
3. Yang L, Dong C, Tian L, Ji X, Yang L, Li L*.Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury. Int J Mol Sci. 2019,20(15):1-17.SCI
4. Yang J#, Chang N#, Yang L, Ji X, Zhou X, Tian L, Ma Y, Yang Y, Liu Y, Yang L, Li L*.Sphingosine 1-Phosphate Receptor Blockade Affects Pro-Inflammatory Bone Marrow-Derived Macrophages and Relieves Mouse Fatty Liver Injury. Int J Mol Sci. 2019,20(19):1-18.SCI
5. Chang N#, Tian L#, Ji X, Zhou X, Hou L, Zhao X, Yang Y, Yang L, Li L*.Single-Cell Transcriptomes Reveal Characteristic Features of Mouse Hepatocytes with Liver Cholestatic Injury. Cells. 2019,8(9):1069.SCI
6. Yang L#, Dong C#, Yang J, Yang L, Chang N, Qi C, Li L*.MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta. Mol Ther Nucleic Acids. 2019,16:206-217.SCI
7. Yang J, Yang L, Tian L, Ji X, Yang L, Li L*.Sphingosine 1-Phosphate (S1P)/S1P Receptor2/3 Axis Promotes Inflammatory M1 Polarization of Bone Marrow-Derived Monocyte/Macrophage via G(α)i/o/PI3K/JNK Pathway. Cell Physiol Biochem. 2018,49(5):1677-1693.SCI
8. Yang L, Yang L, Dong C, Li L*.The class D scavenger receptor CD68 contributes to mouse chronic liver injury. Immunol Res. 2018,66(3):414-424.SCI
9. Wang L#, Yang L#, Tian L#, Mai P, Jia S, Yang L, Li L*.Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury. J Cell Physiol. 2017,232:110-21.SCI
10. Tian L, Li W, Yang L, Chang N, Fang X, Ji X, Xie J, Yang L, Li L*.Cannabinoid Receptor 1 Participatesin Liver Inflammation by Promoting M1 Macrophage Polarization via RhoA/NF-κB p65 and ERK1/2Pathways, Respectively, in MouseLiver Fibrogenesis. Front Immunol. 2017,8:1214.SCI
11. Chang N, Ge J, Xiu L, Zhao Z, Duan X, Tian L, Xie J, Yang L, Li L*.HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. J Mol Med (Berl). 2017,95:69-82.SCI
12. Li W, Chang N, Tian L, Yang J, Ji X, Xie J, Yang L, Li L*. miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury. J Mol Med (Berl). 2017,95:1091-105.SCI
13. Xie J, Yang L, Tian L, Li W, Yang L, Li L*.Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury. Sci Rep. 2016,6:27665.SCI
14. Ge J#, Chang N#, Zhao Z, Tian L, Duan X, Yang L, Li L*.Essential Roles of RNA- binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1. Sci Rep. 2016,6:22141.SCI
15. Mai P, Yang L, Tian L, Wang L, Jia S, Zhang Y, Liu X, Yang L, Li L*.Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner. J Immunol. 2015,195(7):3390-401.SCI
16. Yang L#, Han Z#, Tian L, Mai P, Zhang Y, Wang L, Li L*.Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice. Sci Rep. 2015,5:13423.SCI
17. Liu X#, Jia S#, Li W, Yang L, Yang L, Wang L, Li L*.15-Deoxy-Δ(12,14) -Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway. PPAR Res. 2015,2015:876160.SCI
18. Jia S, Liu X, Li W, Xie J, Yang L, Li L*.Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis. Cell Physiol Biochem. 2015,37(6):2085-2100.SCI
19. Xiu L#, Chang N#, Yang L, Liu X, Yang L, Ge J, Li L*.Intracellular Sphingosine 1-Phosphate Contributes to Collagen Expression of Hepatic Myofibroblasts in Human Liver Fibrosis Independent of Its Receptors. Am J Pathol. 2015,185(2):387-398.SCI
20. Mai P#, Tian L#, Yang L, Wang L, Yang L, Li L*.Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(α)i/o /RhoA/ROCK signaling pathway. J Cell Physiol. 2015,230:1640-50.SCI
21. Chang N, Xiu L, Li L*.Sphingosine 1-Phosphate Receptors Negatively Regulate Collagen Type I/III Expression in Human Bone Marrow-derived Mesenchymal Stem Cell. J Cell Biochem. 2014,115:359-67.SCI
22. Yang L#, Yue S#, Yang L, Liu X, Han Z, Zhang Y, Li L*.Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis is Involved in Liver Fibrosis-Associated Angiogenesis. J Hepatol. 2013,59:114-23.SCI
23. Yang L, Chang N, Liu X, Han Z, Zhu T, Li C, Yang L, Li L*.Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-beta 1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptors Axis. Am J Pathol. 2012,181(1):85-97.SCI
24. Han Z#, Zhu T#, Liu X#, Li C, Yue S, Liu X, Yang L, Yang L, Li L*.15-Deoxy-Δ12,14 -prostaglandin J(2) reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. Hepatology. 2012,56(1):350-60.SCI
25. Liu X#, Yu H#, Yang L, Li C, Li L*.15-Deoxy-delta12,14-prostaglandin J2 attenuates the biological activities of monocyte/macrophage cell lines. Eur J Cell Biol. 2012,91:654-61.SCI
26. Li C, Zheng S, You H, Liu X, Lin M, Yang L, Li L*.Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol. 2011,54(6):1205-13.SCI
27. Liu X#, Yue S#, Li C, Yang L, You H, Li Liying*.Essential roles of sphingosine 1-phosphate receptor type 1 and 3 in human hepatic stellate cells motility and activation. J Cell Physiol. 2011,226(9):2370-7.SCI
28. Wang H, Wang S, Hu J, Kong Y, Chen S, Li L*, Li Liying*.Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor. Histochem Cell Biol. 2009,131(5):553-63.SCI
29. Li C#, Kong Y#, Wang H#, Wang S, Yu H, Liu X, Yang L, Jiang X, Li L*, Li Liying*.Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. J Hepatol. 2009,50(6):1174-83.SCI
30. Li C#, Jiang X#, Yang L, Liu X, Yue S, Li Liying*.Involvement of sphingosine 1-phosphate (S1P)/S1P3 signaling in cholestasis-induced liver fibrosis. Am J Pathol. 2009,175(4):1464-72.SCI
31. Serriere-Lanneau V, Teixeira-Clerc F, Li L, Schippers M, De Wries W, Julien B, Tran-Van-Nhieu J, Manin S, Poelstra K, Chun J, Carpentier S, Levade T, Mallat A, Lotersztajn S.The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J. 2007,21:2005-13.SCI
32. Teixeira-Clerc F, Julien B, Grenard P, Tran-Van-Nhieu J, Deveaux V, Li L, Serriere-Lanneau V, Ledent C, Mallat A, Lotersztajn S.CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med. 2006,12:671-6.SCI
33. Julien B, Grenard P, Teixeira-Clerc F, Van Nhieu JT, Li L, Karsak M, Zimmer A, Mallat A, Lotersztajn S.Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenerology. 2005,128:742-55.SCI
34. Li L, Julien B, Grenard P, Teixeira-Clerc F, Mallat A, Lotersztajn S.Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts. J Hepatol. 2004,41:407-13.SCI
35. Li L, Grenard P, Tran Van Nhieu, Julien B , Mallat A, Habib A, Lotersztajn S.Heme Oxygenase is an antifibrogenic protein in human hepatic myofibroblasts. Gastroenerology. 2003,125:460-8.SCI
36. Davaille J, Li L, Mallat A, Lotersztajn S.Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. J Biol Chem. 2002,277:37323-30.SCI
37. Li L, Tao J, Davaille J, Feral C, Mallat A, Rieusset J, Vidal H, Lotersztajn S.15-deoxy-Delta 12, 14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J Biol Chem. 2001,276:38152-8.SCI
38. Davaille J, Gallois C, Habib A, Li L, Mallat A, Tao J, Levade T, Lotersztajn S.Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. J Biol Chem. 2000,275:34628-33.SCI
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