姓名：王珏 性别：女 职称：副教授 招生院所：基础医学院 招生类型：科学学位(硕) 招生专业：生物化学与分子生物学(硕) 研究方向名称：神经突触相关蛋白的结构与功能 电子信箱：juelab@163.com


社会任职
个人简历
1. 200109-200507:清华大学 学习
2. 200509-201101:清华大学 学习
3. 201103-201512:清华大学 任职
4. 201601-:苏州大学 任职
5. 202003-:首都医科大学 任职
重要学术论文
1. Wang H#, Ma Q#, Qi Y#, Dong J, Du X, Rae J, Wang J, Wu WF, Brown AJ, Parton RG, Wu JW* and Yang H*.ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2). Molecular Cell. 2019,73(3):458-473.SCI
2. Dong J#, Du X#, Wang H#, Wang J, Lu C, Chen X, Zhu Z, Luo Z, Yu L, Brown AJ, Yang H* and Wu JW*.Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nature Communications. 2019,10(1):829.SCI
3. Wang YL#, Zhang YY#, Lu C, Zhang W, Deng H, Wu JW, Wang J* and Wang ZX*.Kinetic and mechanistic studies of p38alpha MAP kinase phosphorylation by MKK6. FEBS Journal. 2019,286(5):1030-1052.SCI
4. Wang YL, Wang J, Chen X, Wang ZX and Wu JW*.Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family. Biochemical and Biophysical Research Communications. 2018,495(1):1-6.SCI
5. Zhao YY#, Mao MW#, Zhang WJ#, Wang J, Li HT, Yang Y, Wang Z* and Wu JW*.Expanding RNA binding specificity and affinity of engineered PUF domains. Nucleic Acids Research. 2018,46(9):4771-4782.SCI
6. Li SJ#, Wang J#, Ma L#, Lu C, Wang J, Wu JW* and Wang ZX*.Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Cell Research. 2016,26(3):336-349.SCI
7. Wu JX, Cheng YS, Wang J, Chen L, Ding M and Wu JW*.Structural insight into the mechanism of synergistic autoinhibition of SAD kinases. Nature Communications. 2015,6:8953.SCI
8. Chai N, Li WX, Wang J, Wang ZX, Yang SM* and Wu JW*.Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Research. 2015,43(18):9051-9064.SCI
9. Wang J#, Jiang J#, Wang J#, Chen L, Fan SL, Wu JW, Wang X and Wang ZX*.Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1. Cell Research. 2014,24(11):1328-1341.SCI
10. Xin FJ#, Wang J#, Zhao RQ, Wang ZX and Wu JW*.Coordinated regulation of AMPK activity by multiple elements in the alpha-subunit. Cell Research. 2013,23(10):1237-1240.SCI
11. Chen L, Xin FJ, Wang J, Hu J, Zhang YY, Wan S, Cao LS, Lu C, Li P, Yan SF, Neumann D, Schlattner U, Xia B, Wang ZX and Wu JW*.Conserved regulatory elements in AMPK. Nature. 2013,498(7453):E8-10.SCI
12. Chen L, Wang J, Zhang YY, Yan SF, Neumann D, Schlattner U, Wang ZX and Wu JW*.AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nature Structural & Molecular Biology. 2012,19(7):716-718.SCI
13. Wang J, Wu JW and Wang ZX*.Structural insights into the autoactivation mechanism of p21-activated protein kinase. Structure. 2011,19(12):1752-1761.SCI
14. Wang J, Wu JW and Wang ZX*.Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification. Journal of Biological Chemistry. 2011,286(4):2689-2695.SCI
15. Gao X, Wang J, Yu DQ, Bian F, Xie BB, Chen XL, Zhou BC, Lai LH, Wang ZX, Wu JW* and Zhang YZ*.Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family. Proceedings of the National Academy of Sciences of the United States of America. 2010,107(41):17569-17574.SCI
主编或副主编的著作/译著
重要奖项