姓名：安静 性别：女 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：病原生物学(博) 病原生物学(硕) 研究方向名称：病毒的致病机理与预防手段 电子信箱：anjing@ccmu.edu.cn


社会任职
1. 微生物与感染杂志特约编委
2. 中华医学会医学病毒学专委会委员
3. 中华医学会医学人兽共患病学专委会委员
4. 热带医学与人体寄生虫学专业委员会委员
5. 微生物学免疫学进展编委
6. Infection International编委
7. 《VIROLOGICA SINICA》编委
个人简历
1. 197802-198212:中国医科大学医疗系毕业 本科生
2. 198301-198512:第三军医大学烧伤外科学专业 硕士研究生
3. 198601-198907:第三军医大学烧伤外科学专业 博士研究生
4. 199308-200009:日本东京都神经科学综合研究所微生物学研究室 博士后
5. 200010-200612:第三军医大学微生物教研室 教授、博导
6. 200512-:首都医科大学微生物教研室 教授、博导
重要学术论文
1. Qiaoli Luo, Yisong Wang, Dongying Fan, Shijie Wang, Peigang Wang*, Jing An*.Prion Protein Expression is Correlated with Glioma Grades. Virologica Sinica. 2020,【未填写卷（期）】:【未填写起止页码】.SCI
2. Kaihao Feng, Xiaoyan Zheng, Ran Wang, Na Gao, Dongying Fan, Ziyang Sheng, Hongning Zhou, Hui Chen*, Jing An*.Long-Term Protection Elicited by a DNA Vaccine Candidate Expressing the prM-E Antigen of Dengue Virus Serotype 3 in Mice. Frontiers in Cellular and Infection Microbiology. 2020,10:87.SCI
3. Ran Wang1, Na Gao, Yun Li, Dongying Fan, Zida Zhen, Kaihao Feng, Hui Chen* and Jing An*.Cross-Protection Against Four Serotypes of Dengue Virus in Mice Conferred by a Zika DNA Vaccine. Frontiers in Cellular and Infection Microbiology. 2019,9:147.SCI
4. Ziyang Sheng, Hui Chen, Kaihao Feng, Na Gao, Ran Wang, Peigang Wang, Dongying Fan, Jing An*.Electroporation-Mediated Immunization of a Candidate DNA Vaccine Expressing Dengue Virus Serotype 4 prM-E Antigen Confers Long-Term Protection in Mice. Virologica Sinica. 2019,34:88-96.SCI
5. Ran Wang, Xiaoyan Zheng, Jin Sun, Kaihao Feng, Na Gao, Dongying Fan, Hui Chen*, Xia Jin* and Jing An*.Vaccination With a Single Consensus Envelope Protein Ectodomain Sequence Administered in a Heterologous Regimen Induces Tetravalent Immune Responses and Protection Against Dengue Viruses in Mice. Frontiers in Microbiology. 2019,10:1113.SCI
6. Na Gao#, Jieqiong Li#, Ziyang Sheng, Hui Chen, Dongying Fan, Peigang Wang, Jing An*.Japanese encephalitis virus prM-E antigen immunization conferred protection against challenge by four different serotypes of Dengue viruses in mice. Applied Microbiology and Biotechnology. 2019,103:4977–4986.SCI
7. Ran Wang#, Lyu Xie#, Na Gao, Dongying Fan, Hui Chen, Peigang Wang, Hongning Zhou*, Jing An*.Decreases in Both the Seroprevalence of Serum Antibodies and Seroprotection against Japanese Encephalitis Virus among Vaccinated Children. Virologica Sinica. 2019,34:243–252.SCI
8. Xiaoyun Cui, Yanhua Wu, Dongying Fan, Na Gao, Ying Ming, Peigang Wang, Jing An∗.Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin. Antiviral Research. 2018,155:20-27.SCI
9. Ran Wang ; Xianzheng Liao; Dongying Fan; Lei Wang; Ji Song; Kaihao Feng; Mingyuan Li; Peigang Wang;Hui Chen*;Jing An*.Maternal immunization with a DNA vaccine candidate elicits specific passive protection against post-natal Zika virus infection in immunocompetent BALB/c mice. Vaccine. 2018,36:3522~3532.SCI
10. Yan-Hua Wu ; Xiao-Yun Cui ; Wei Yang; Dong-Ying Fan; Dong Liu; Pei-Gang Wang*;Jing An*.Zika Virus Infection in Hypothalamus Causes Hormone Deficiencies and Leads to Irreversible Growth Delay and Memory Impairment in Mice. Cell Reports. 2018,25:1537~1547.SCI
11. Zi-Yang Sheng，Na Gao， Zhao-Yang Wang，Xiao-Yun Cui，De-Shan Zhou，Dong-Ying Fan，Hui Chen1, Pei-Gang Wang，and Jing An*.Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis. Frontiers in Cellular and Infection Microbiology. 2017,7:272（1-13）.SCI
12. Zhao-Yang Wang, Zai Wang,Zi-Da Zhen,Kai-Hao Feng, Jing Guo, Na Gao, Dong-Ying Fan, Dai-Shu Han,Pei-Gang Wang,* and Jing An*.Axl is not an indispensable factor for Zika virus infection in mice. Journal of General Virology. 2017,98:2061–2068.SCI
13. Xiaoyan Zheng, Hui Chen, Ran Wang, Dongying Fan, Kaihao Feng, Na Gao and Jing An.Effective Protection Induced by a Monovalent DNA Vaccine against Dengue Virus (DV) Serotype 1 and a Bivalent DNA Vaccine against DV1 and DV2 in Mice. Frontiers in Cellular and Infection Microbiology. 2017,7:175（1-12）.SCI
14. Yanhua Wu, Xiaoyun Cui, Na Wu, Rui Song, Wei Yang, Wei Zhang, Dongying Fan, Zhihai Chen & Jing An*.A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders. Scientific Reports. 2017,7:11393.SCI
15. Hui Chen, Xiaoyan Zheng, Ran Wang, Na Gao, Ziyang Sheng , Dongying Fan, Kaihao Feng,Xianzheng Liao, Jing An*.Immunization with electroporation enhances the protective effect of a DNA vaccine candidate expressing prME antigen against dengue virus serotype 2 infection. Clinical Immunology. 2016,171 (2016) :41–49.SCI
16. Ziyang Sheng, Na Gao, Xiaoyun Cui, Dongying Fan, Hui Chen, Na Wu, Jianchun Wei, Jing An*.Electroporation enhances protective immune response of a DNA vaccine . Vaccine. 2016,2016(34):5751–5757.SCI
17. Jieqiong Li, Na Gao, Dongying Fan, Hui Chen, Ziyang Sheng, Shihong Fu,Guodong Liang*, Jing An*.Cross-protection induced by Japanese encephalitis vaccines against different genotypes of Dengue viruses in mice. Scientific reports. 2016,6:19953.SCI
18. Xing Y#, Wang Y#, Wang S, Wang X, Fan D, Zhou D, An J*.Human cytomegalovirus infection contributes to glioma disease progression via upregulatingendocan expression. Transl Res. 2016,177:113-126.SCI
19. Na Wu, Na Gao, Dongying Fan, Jianchun Wei, Jing Zhang, Jing An.miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells. Microbes and Infection. 2014,16(2014):911e922.SCI
20. Hui Chen, Na Gao, Jiangman Wu, Xiaoyan Zheng, Jieqiong Li,Dongying Fan, Jing An*.Variable effects of the co-administration of a GM-CSF-expressingplasmid on the immune response to flavivirus DNA vaccines in mice. Immunology Letters. 2014,162(2014):140–148.SCI
21. Juan Wang, Yanlei Chen, Na Gao, Yisong Wang, Yanping Tian, Jiangman Wu, Junlei Zhang,Junping Zhu, Dongying Fan, Jing An*.Inhibitory Effect of Glutathione on Oxidative Liver Injury Induced by Dengue Virus Serotype 2 Infections in Mice. PLoS One . 2013,8(1):e55407.SCI
22. Jieqiong Li, Hui Chen, Na Wu, Dongying Fan, Guodong Liang, Na Gao*, Jing An*.Characterization of immune responses induced by inactivated,live attenuated and DNA vaccines against Japanese encephalitis encephalitisvirus in mice. Vaccine. 2013,31:4136-4142.SCI
23. JP Zhu, Z Luo, J Wang, ZG Xu, H Chen, DY Fan, N Gao, GL Ping, Z Zhou, Y Zhan, J An*.Phylogenetic analysis of Enterovirus 71 circulating in Beijing, China from 2007 to 2009. PLoS One . 2013,8(2):e56318.SCI
24. H Lu, XF Xu, N Gao, DY Fan, J Wang, J An*.Preliminary evaluation of DNA vaccine candidates encoding dengue-2 prM/E and NS1:Their immunity and protective efficacy in mice. Mol Immunol . 2013,54 :109-114.SCI
25. Hui Chen，Na Gao，Jing An .Suppressive effects on the immune response and protective immunity to a JEV DNA vaccine by the co-administration of a GM-CSF-expressing plasmid in mice. PLos One. 2012,7(4):e34602.SCI
26. Qun Zheng, Dongying Fan, Na Gao, Hui Chen, Juan Wang, Ying Ming, Jieqiong Li, Jing An*.Evaluation of a DNA vaccine candidate expressing prM-E-NS1 antigens of dengue virus serotype 1 with or without granulocyte-macrophage colony-stimulating factor (GM-CSF) in immunogenicity and protection. Vaccine. 2011,29:763-771.SCI
27. Jia-Li Wang, Jun-Lei Zhang, Wei Chen, Xiao-Feng Xu, Na Gao, Dong-Ying Fan, Jing An*.Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during Dengue Virus infection. PLoS NTD. 2010,4（8）:e809.SCI
28. Limei Liu, Yanping Tian;Gao,Na; Jing An*.Application of antibodies against nonstructural protein 2B of dengue serotype 2 virus induced by DNA immunization or recombinant protein NS 2B immunization in BALB/c mice. J Virol. Method. 2010,163 (1) :10–16 .SCI
29. Gao Na; Chen Wei; Zheng Qun;Fan dy;Jing An#.Co-expression of Japanese encephalitis virus prM-E-NS1 antigen with granulocyte-macrophage colony-stimulating factor enhances humoral and anti-virus immunity after DNA vaccination. Immunology Letter . 2010,129(1)：:23-31.SCI
30. Yanping Tian, Wen Jiang, Na Gao, Junlei Zhang, Wei Chen, Dongying Fan, Deshan Zhou, Jing An.Inhibitory effects of glutathione on dengue virus production. Biochemical and Biophysical Research Communications. 2010,397:420-424.SCI
31. Zongtao Chen，Li-Mei Liu，Na Gao，Xiao-Feng Xu，Jun-Lei Zhang，Jia-Li Wang， Jing An*.Passive Protection Assay of Monoclonal Antibodies Against. Curr Microbiol. 2009,58（4):326-331.SCI
32. Tao Peng，Jia-Li Wang，Wei Chen，Jun-Lei Zhang，Na Gao，Zong-tao Chen，Xiao-Feng Xu，Dong-Ying Fan，and Jing An*.Entry of dengue virus serotype 2 into ECV304 cells depends on clathrin-dependent endocytosis, but not on caveolae-dependent endocytosis. Can.J. Microbiol.. 2009,55:139-145.SCI
33. XF Xu, ZT Chen, N Gao, JL Zhang, J An.Myosin Vc, a Member of the Actin Motor Family Associated with Rab8, Is Involved in the Release of DV2 from HepG2 Cells. Intervirology . 2009,52:258-265.SCI
34. Wei Chen，Na Gao，Jia-li Wang，Yan-ping Tian，Zong-tao Chen，Jing An*.Vimentin is required for dengue virus serotype 2 infection but microtubules are not necessary for this process . Archives of Virology. 2008,153(9):1777-1781.SCI
35. XF Xu, ZT Chen, JL Zhang ,W Chen, JL Wang, YP Tian, N Gao, J An.Rab8, a Vesicular Traffic Regulator, Is Involved in Dengue Virus Infection in HepG2 Cells. Intervirology . 2008,51:182-188.SCI
36. Junlei Zhang，Jiali Wang,Na Gao, Zongtao Chen, Yanping Tian,Jing An*.Up-regulated expression of β3 integrin induced by dengue virus serotype 2 infection associated with viral entry into human dermal microvascular endothelial cells. Biochemical and Biophysical Research Communications. 2007,356:763-768.SCI
37. R Jian, T Peng，SL Deng，J Jiang, FQ Hu，J An，XX Cheng.A Simple Strategy for Generation of Gene Knockdown Constructs by Using Convergent H1 and U6 Promoters. E. J. Cell. Biol. 2006,85:433-440.SCI
主编或副主编的著作/译著
重要奖项
1. 登革病毒的致病机理与预防手段的研究 军队科技进步奖 二等奖 2009