姓名：孙志伟 性别：男 职称：教授 招生院所：公共卫生学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：卫生毒理学(博) 卫生毒理学(硕) 研究方向名称：纳米毒理学、颗粒物毒理 电子信箱：zwsun@ccmu.edu.cn


社会任职
1. 中华预防医学会理事
2. 中国毒理学会理事
3. 中华预防医学会公共卫生教育专业委员会委员
4. 中国毒理学会遗传毒理专业委员会副主任委员
5. 中国毒理学会纳米毒理专业委员会副主任委员
6. 中华预防医学会卫生毒理分会主任委员
7. 中国毒理学会呼吸毒理专业委员会主任委员
8. 中华预防医学会卫生毒理分会名誉主任委员
个人简历
1. 197909-198406:白求恩医科大学 学士
2. 198709-199006:白求恩医科大学 硕士
3. 199009-199206:白求恩医科大学 讲师
4. 199209-199502:联邦德国Mainz大学 博士
5. 199506-199707:白求恩医科大学 副教授 博士后
6. 199709-200006:白求恩医科大学 教授
7. 200007-200902:吉林大学 教授
8. 200903-:首都医科大学 教授
重要学术论文
1. Shuang Liang#, Yueyue Chen#, Shiming Zhang, Yuanyuan Cao, Yapei Wang*, Junchao Duan*, Zhiwei Sun*.RhB-encapsulating Silica Nanoparticles Modified with PEG impact the Vascular Endothelial Function in Endothelial Cells and Zebrafish Model. Science of the total environment. 2020,711:134493.SCI
2. Jingyi Zhang#, Shuang Liang#, Ruihong Ning, Jinjin Jiang, Jie Zhang, Heqing Shen, Rui Chen, Junchao Duan*, Zhiwei Sun*.PM2.5-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis. Environment International. 2020,136:105444.SCI
3. Yang Li, Baiyang Sun, Yanfeng Shi, Jinjin Jiang, Zhou Du, Rui Chen, Junchao Duan*, Zhiwei Sun*.Subacute exposure of PM2.5 induces airway inflammation through inflammatory cell infiltration and cytokine expression in rats. Chemosphere. 2020,251:126423.SCI
4. Yanfeng Shi, Josevata Werelagi Batibawa, Modibo Maiga, Baiyang Sun, Yang Li, Junchao Duan*, Zhiwei Sun*.Identification and Validation of Metformin Protects Against PM2.5-induced Macrophages Cytotoxicity by Targeting Toll Like Receptor Pathway. Chemosphere. 2020,251:126526.SCI
5. Yuanfeng Pang, Jinmaio Shi, Xingsheng Yang, Chongwen Wang*, Zhiwei Sun*, Rui Xiao *.Personalized detection of circling exosomal PD-L1 based on Fe3O4@TiO2 isolation and SERS immunoassay. Biosens Bioelectron. 2020,148:111800.SCI
6. Baiyang Sun#, Yanfeng Shi#, Yang Li, Jinjin Jiang, Shuang Liang, Junchao Duan*, Zhiwei Sun*.Short-term PM2.5 exposure induces sustained pulmonary fibrosis development during post-exposure period in rats. Journal of Hazardous Materials. 2020,385:121566.SCI
7. Jinjin Jiang, Yang Li, Shuang Liang, Baiyang Sun, Yanfeng Shi, Qing Xu, Jie Zhang, Heqing Shen, Junchao Duan*, Zhiwei Sun*.Combined exposure of fine particulate matter and high-fat diet aggravate the cardiac fibrosis in C57BL/6J mice. Journal of Hazardous Materials. 2020,391:122203.SCI
8. Yanfeng Shi, Tong Zhao, Xiaozhe Yang, Baiyang Sun, Yang Li, Junchao Duan*, Zhiwei Sun*.PM2.5-induced the alteration of DNA methylation and RNA-transcription are associated with inflammatory response and lung injury. Science of the Total Environment. 2019,650:908-921.SCI
9. Shuang Liang#, Tong Zhao#, Hejing Hu, Yanfeng Shi, Qing Xu, Mark R. Miller, Junchao Duan*, Zhiwei Sun*.Repeat dose exposure of PM2.5 triggers the Disseminated Intravascular Coagulation (DIC) in SD Rats. Science of the Total Environment. 2019,663:245-253.SCI
10. Jianhui Liu#, Jin Zhang#, Lihua Ren, Jialiu Wei, Yupeng Zhu, Junchao Duan, Li Jing, Zhiwei Sun*, Xianqing Zhou*.Fine particulate matters induce apoptosis via the ATM/P53/CDK2 and mitochondria apoptosis pathway triggered by oxidative stress in rat and GC-2spd cell. Ecotoxicol Environ Saf. 2019,180:280-287.SCI
11. Lin Feng, Xiaozhe Yang, Shuang Liang, Qing Xu, Mark R. Miller, Junchao Duan*, Zhiwei Sun*.Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway. Particle and Fibre Toxicology. 2019,16:16.SCI
12. Yannan Zhang#, Mengtian Chu#, Jingyi Zhang, Junchao Duan*, Dayu Hu, Wenlou Zhang, Xuan Yang, Xu Jia, Furong Deng*, Zhiwei Sun*.Urine metabolites associated with cardiovascular effects from exposure of size-fractioned particulate matter in a subway environment: a randomized crossover study. Environment International. 2019,130:104920.SCI
13. Yang Yu, Tingting Zhu, Yang Li, Li Jing, Man Yang, Yanbo Li, Junchao Duan*, Zhiwei Sun*.Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo. International Journal of Nanomedicine. 2019,14:7237-7247.SCI
14. Yuanfeng Pang#, Nan Wan#, Luoluo Shi, Chongwen Wang*, Zhiwei Sun*, Rui Xiao*, Shengqi Wang*.Dual-recognition surface-enhanced Raman scattering(SERS)biosensor for pathogenic bacteria detection by using vancomycin-SERS tags and aptamer-Fe3O4@Au. Anal Chim Acta. 2019,1077:288-296.SCI
15. Yang Li#, Junchao Duan#, Xiangyuan Chai, Man Yang, Ji wang, Rui Chen*, Zhiwei Sun*.Microarray assisted size effect study of amorphous silica nanoparticles on human bronchial epithelial cells. Nanoscale. 2019,11(47):22907-22923.SCI
16. Yuanfeng Pang, Chaoguang Wang, LuChun Lu, Chongwen Wang*, Zhiwei Sun*, Rui Xiao*.Dual-SERS biosensor for one-step detection of microRNAs in exosome and residual plasma of blood samples for diagnosing pancreatic cancer. Biosens Bioelectron. 2019,130:204-213.SCI
17. Xiaozhe Yang, Tong Zhao, Lin Feng, Yanfeng Shi, Jinjin Jiang, Shuang Liang, Baiyang Sun, Qing Xu, Junchao Duan*, Zhiwei Sun*.PM2.5-induced ADRB2 Hypermethylation Contributed to Cardiac Dysfunction through Cardiomyocytes Apoptosis via PI3K/Akt Pathway. Environment International. 2019,127:601-614.SCI
18. Yuanfeng Pang,Chongwen Wang, Zhiwei Sun*, Rui Xiao.Dual-selective and dual enhanced SERS nanoprobes strategy for circulating hepatocellular carcinoma cells detection. Chemistry. 2018,24(27):7060-7067.SCI
19. Ji Wang, Yang Li, Juanchao Duan, Man Yang, Yang Yu, Lin Feng, Xiaozhe Yang, Xianqing Zhou, Zhendong Zhao*, Zhiwei Sun*.Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes. Autophagy. 2018,14(7):1185-1200.SCI
20. Yannan Zhang, Yanbo Li, Zhixiong Shi, Jing Wu, Xiaozhe Yang, Lin Feng, Lihua Ren, Junchao Duan*, Zhiwei Sun*.Metabolic impact induced by total, water soluble and insoluble components of PM2.5 acute exposure in mice. Chemosphere. 2018,207:337-346.SCI
21. Xiaozhe Yang, Lin Feng, Yannan Zhang, Hejing Hu, Yanfeng Shi, Shuang Liang, Tong Zhao, Yang Fu, Junchao Duan*, Zhiwei Sun*.Cytotoxicity induced by fine particulate matter (PM2.5) via mitochondria-mediated apoptosis pathway in human cardiomyocytes. Ecotoxicology and Environmental Safety. 2018,161:198-207.SCI
22. Baiyang Sun, Yanfeng Shi, Xiaozhe Yang, Tong Zhao, Junchao Duan*, Zhiwei Sun*.DNA methylation: A critical epigenetic mechanism underlying the detrimental effects of airborne particulate matter. Ecotoxicology and Environmental Safety. 2018,161:173-183.SCI
23. Xiaozhe Yang, Lin Feng, Yannan Zhang, Yanfeng Shi, Shuang Liang, Tong Zhao, Baiyang Sun, Junchao Duan*, Zhiwei Sun*.Integrative analysis of methylome and transcriptome variation of identified cardiac disease-specific genes in human cardiomyocytes after PM2.5 exposure. Chemosphere. 2018,212:915-926.SCI
24. Junchao Duan, Shuang Liang, Lin Feng, Yang Yu*, Zhiwei Sun*.Silica nanoparticles trigger the hepatic lipid metabolism disorder in vivo and in vitro. International Journal of Nanomedicine. 2018,13:7303-7318.SCI
25. Caixia Guo, Ma Ru, Xiaoying Liu, Tian Chen, Yang Li, Yang Yu, Junchao Duan, Xianqing Zhou, Yanbo Li*, Zhiwei Sun*.Silica nanoparticles promote oxLDL-induced macrophage lipid accumulation and apoptosis via endoplasmic reticulum stress signaling. Sci Total Environ. 2018,631-632:570-579.SCI
26. Junchao Duan, Shuang Liang, Yang Yu, Yang Li, Lijing Wang, Zehao Wu, Yueyue Chen*, Mark R. Miller, Zhiwei Sun*.Inflammation-coagulation Response and Thrombotic Effects Induced by Silica Nanoparticles in Zebrafish Embryos. Nanotoxicology. 2018,Apr 14:1-15:Doi: 10.1080/**.2018.**.SCI
27. Chen H*, Chen Y*, Wu Han, Xu J, Sun Z*, Zhang X*.Supramolecular polymeric chemotherapy based on cucurbit[7]uril-PEG copolymer. Biomaterials. 2018,S0142-9612(18):30151-0.SCI
28. Xiaozhe Yang, Lin Feng, Yannan Zhang, Hejing Hu, Yanfeng Shi, Shuang Liang, Tong Zhao, Lige Cao, Junchao Duan*, Zhiwei Sun*.Co-exposure of silica nanoparticles and methylmercury induced cardiac toxicity in vitro and in vivo. Science of the Total Environment. 2018,631-632:811-821.SCI
29. Hao Q, Chen Y, Huang Z, Xu J, Sun Z*, Zhang X*.Supramolecular chemotherapy: carboxylated pillar[6]arene for decreasing cytotoxicity of oxaliplatin to normal cells and improving its anticancer bioactivity against colorectal cancer.. ACS Appl. Mater. Interfaces. 2018,10(6):5365-5372.SCI
30. Lin Feng, Xiaozhe Yang, Yanfeng Shi, Shuang Liang, Tong Zhao, Junchao Duan*, Zhiwei Sun*.Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. International Journal of Nanomedicine. 2018,13:7819-7834.SCI
31. Collins Otieno Asweto, Jing Wu, Mohamed Ali Alzain, Hejing Hu, Sebastian Andrea, Lin Feng , Xiaozhe Yang, Junchao Duan*, Zhiwei Sun*.Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies. Environmental Toxicology and Pharmacology. 2017,56:191-197.SCI
32. Hejing Hu#, Collins Otieno Asweto#, Jing Wu, Yanfeng Shi, Lin Feng, Xiaozhe Yang, Shuang Liang, Lige Cao, Junchao Duan*, Zhiwei Sun*.Gene expression profiles and bioinformatics analysis of human umbilical vein endothelial cells exposed to PM2.5. Chemosphere. 2017,183:589-598.SCI
33. Hejing Hu, Yanfeng Shi, Yannan Zhang, Jing Wu, Collins Otieno Asweto, Lin Feng, Xiaozhe Yang, Junchao Duan*, Zhiwei Sun*.Comprehensive gene and microRNA expression profiling on cardiovascular system in zebrafish co-exposured of SiNPs and MeHg. Science of the Total Environment. 2017,608:795-805.SCI
34. Li Jing, ManYang, YangLi, YangYu, Baolu Liang, Lige Cao, Xianqing Zhou, Shuangqing Peng*, Zhiwei Sun*.Metallothionein prevents doxorubicin cardiac toxicity by indirectly regulating the uncoupling proteins 2. Food and Chemical Toxicololgy. 2017,110:204-213.SCI
35. Yongbo Yu, Junchao Duan, Yang Yu, Yang Li, Zhiwei Sun*.Silica Nanoparticle-Induced Blockage of Autophagy Leads to Autophagic Cell Death in HepG2 Cells. Journal of Biomedical Nanotechnology. 2017,15:485-499.SCI
36. Caixia Guo, Ji Wang, Man Yang, Yang Li, Shuxiang Cui, Xianqing Zhou, Yanbo Li*, Zhiwei Sun*.Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells via P53 signaling. Nanotoxicology. 2017,11(9-10):1176-1194.SCI
37. Chen Y, Huang Z, Xu JF, Sun Z*, Zhang X*.Supramolecular chemotherapy: cooperative enhancement of antitumor activity by combining controlled release of oxaliplatin and consuming of spermine by cucurbit[7]uril. ACS Appl. Mater. Interfaces. 2017,9(10):8602-8608.SCI
38. Lin Feng, Xiaozhe Yang, Collins Otieno Asweto, Jing Wu, Yannan Zhang, Hejing Hu, Yanfeng Shi, Junchao Duan*, Zhiwei Sun*.Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2.5 in human myocardial cells. Environmental science and pollution research. 2017,24(12):11683-11693.SCI
39. Junchao Duan, Yang Yu, Yang Li, Li Jing, Man Yang, Ji Wang, Yanbo Li, Xianqing Zhou, Mark R. Miller, Zhiwei Sun*.Comprehensive understanding of PM2.5 on gene and microRNA expression patterns in zebrafish (Danio rerio) model. Science of the Total Environment. 2017,586:666-674.SCI
40. Yanyan Yang#, Yongbo Yu#, Jiahui Wang, Yanbo Li, Yang Li, Jia Wei, Tong Zheng, Minghua Jin*, Zhiwei Sun*.Silica nanoparticles induced intrinsic apoptosis in neuroblastoma SH-SY5Y cells via CytC Apaf-1 pathway. Environ Toxicol Pharmacol.. 2017,52:161-169.SCI
41. Junchao Duan, Hejing Hu, Yannan Zhang, Lin Feng, Yanfeng Shi, Mark R. Miller*, Zhiwei Sun*.Multi-organ toxicity induced by fine particulate matter PM2.5 in zebrafish (Danio rerio) model. Chemosphere. 2017,180:24-32.SCI
42. Collins Otieno Asweto, Jing Wu, Hejing Hu, Lin Feng, Xiaozhe Yang, Junchao Duan*, Zhiwei Sun*.Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells. Int. J. Environ. Res. Public Health. 2017,14(3):289.SCI
43. Yannan Zhang, Hejing Hu, Yanfeng Shi, Xiaozhe Yang, Lige Cao, Jing Wu, Collins Otieno Asweto, Lin Feng, Junchao Duan*, Zhiwei Sun*.1H NMR-Based Metabolomics Study on Repeat Dose Toxicity of Fine Particulate Matter in Rats after Intratracheal Instillation. Science of the Total Environment. 2017,589:212-221.SCI
44. Jing Wu#, Yanfeng Shi#, Collins OtienoAsweto, Lin Feng, Xiaozhe Yang,Yannan Zhang, Hejing Hu, Junchao Duan*, Zhiwei Sun*.Fine particle matters induce DNA damage and G2/M cell cycle arrest in human bronchial epithelial BEAS-2B cells. Environmental science and pollution research. 2017,24(32):25071-25081.SCI
45. Hejing Hu#, Jing Wu#, Qiuling Li#, Collins Asweto, Lin Feng, Xiaozhe Yang, Fengkui Duan, Junchao Duan*, Zhiwei Sun*.Fine particulate matter induces vascular endothelial activation via IL-6 dependent JAK1/STAT3 signaling pathway. . Toxicology Research. 2016,5: 946-953.SCI
46. Junchao Duan*, Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Yapei Wang*, Zhiwei Sun*.Combined toxicity of silica nanoparticles and methylmercury on cardiovascular system in zebrafish (Danio rerio) embryos. Environmental Toxicology and Pharmacology. Environmental Toxicology and Pharmacology. 2016,44:120-127.SCI
47. Yongbo Yu, Junchao Duan, Yang Yu, Yang Li, Yang Zou, Yumei Yang, Lizhen Jiang, Qiuling Li, Zhiwei Sun*.Autophagy and autophagy dysfunction contribute to apoptosis in HepG2 cells exposed to nanosilica. . Toxicology Research. 2016,5:871-882.SCI
48. Junchao Duan*, Yang Yu, Yang Li, Yapei Wang, Zhiwei Sun*.Inflammatory response and blood hypercoagulable state induced by low level co-exposure with silica nanoparticles and benzo[a]pyrene in zebrafish (Danio rerio) embryos. Chemosphere. 2016,151:152-162.SCI
49. Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Junchao Duan*, Zhiwei Sun*.Genome-wide transcriptional analysis of silica nanoparticles-induced toxicity in zebrafish embryos. Toxicology Research. 2016,5:609-620.SCI
50. Yuanfeng Pang, Chongwen Wang, Jing Wang, Zhiwei,Sun*,Rui Xiao*, Shengqi Wang*.Fe3O4@Ag magnetic nanoparticles for MicroRNA capture and Duplex-Specific Nuclease signal amplification based SERS detection in Cancer Cells. Biosensors & Bioelectronics. 2016,79:574–580 .SCI
51. Jing Wu, Yanfeng Shi, Collins Asweto, Lin Feng, Xiaozhe Yang, Yannan Zhang, Hejing Hu, Junchao Duan*, Zhiwei Sun*..Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epithelial BEAS-2B cells. Environmental science and pollution research. 2016,23(22):23134-23144.SCI
52. Yang Zou, Qiuling Li, Lizhen Jiang, CaixiaGuo, Yanbo Li, Yang Yu, Yang Li, Junchao Duan*, Zhiwei Sun*.DNA hypermethylation of CREB3L1 and Bcl-2 associated with the mitochondrial-mediated apoptosis via PI3K/Akt pathway in human BEAS-2B cells exposure to silica nanoparticles. PLoS One. 2016,11(6):e**.SCI
53. Yang Li, Yang Yu, Junchao Duan, Zhuolin Li, Weijia Geng, Lizhen Jiang, Ji Wang, Minghua Jin, Xiaomei Liu, Zhiwei Sun*.The Internalization, Distribution, and Ultrastructure Damage of Silica Nanoparticles in Human Hepatic L-02 Cells. Particle & Particle Systems Characterization. 2016,33:664-674.SCI
54. Yueyue Chen#, Zehuan Huang#, Jiangfei Xu, Zhiwei Sun*, Xi Zhang*.Cytotoxicity Regulated by Host-Guest Interactions: A Supramolecular Strategy to Realize Controlled Disguise and Exposure. ACS Appl. Mater. Interfaces. 2016,8(35):22780-22784.SCI
55. Weijia Geng, Yang Li, Yongbo Yu, Yang Yu, Junchao Duan, Lizhen Jiang, Qiuling Li, Zhiwei Sun*.Silica nanoparticles induce multinucleation through activation of PI3K/Akt/GSK-3β pathway and downregulation of chromosomal passenger proteins in L-02 cells. Journal of Nanoparticle Research. 2016,18:97.SCI
56. Qiuling Li, Hejing Hu, Lizhen Jiang, Yang Zou, Junchao Duan*, Zhiwei Sun*.Cytotoxicity and autophagy dysfunction induced by different size of silica particles in human bronchial epithelial BEAS-2B cells. Toxicology Research. 2016,5:1216-1228.SCI
57. Yongbo Yu, Junchao Duan, Yang Li, Yang Yu, Minghua Jin, Chenxu Li, Yapei Wang*, Zhiwei Sun*..Combined toxicity of amorphous silica nanoparticles and methylmercury to human lung epithelial cells. Ecotoxicology and Environmental safety. 2015,112:144-152.SCI
58. Lizhen Jiang, Yanbo Li, Yang Li, Caixia Guo, Yongbo Yu, Yang Zou, Yumei Yang, Yang Yu, Junchao Duan, Weijia Geng, Qiuling Li, Zhiwei Sun*. Silica nanoparticles induced the pre-thrombotic state in rats via activation of coagulation factor XII and JNK- NF-κB/AP-1 pathway. Toxicology Research. 2015,4:1453-1464 .SCI
59. Yongbo Yu, Junchao Duan, Weijia Geng, Qiuling Li, Lizhen Jiang, Yang Li, Yang Yu, Zhiwei Sun*.Aberrant cytokinesis and cell fusion result in multinucleation in HepG2 cells exposed to silica nanoparticles. Chemical Research in Toxicology. 2015,28(3):490-500.SCI
60. Yang Li, Li Jing, Yongbo Yu, Yang Yu, Junchao Duan, Man Yang, Weijia Geng, Lizhen Jiang, Qiuling Li, Zhiwei Sun*.Cytoskeleton and chromosome damage leading to abnormal mitosis were involved in multinucleated cells induced by silicon nanoparticles. Particle &Particle Systems Characterization. 2015,32:636-645 .SCI
61. Jian Wang, Jing Zhao, Yanbo Li, Man Yang, Yuqiang Chang, Jianping Zhang, Zhiwei Sun*, Yapei Wang*.Enhanced Light Absorption in Porous Particles for Ultra-NIR-Sensitive Biomaterals. ACS Macro Letters. 2015,4:392-397 .SCI
62. Caixia Guo, Yinye Xia, Piye Niu, Lizhen Jian, Junchao Duan, Yang Yu, Xianqing Zhou, Yanbo Li, Zhiwei Sun.Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling. Int J Nanomedicine. 2015,10:1463-1477.SCI
63. Junchao Duan, Yongbo Yu, Yang Yu, Yang Li, Peili Huang, Xianqing Zhou, Shuangqing Peng, Zhiwei Sun*.Silica nanoparticles induce autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis. Part Fibre Toxicol. 2014,11:50.SCI
64. Zeng L, Li Y, Li T, Cao W, Yi Y, Geng W, Sun Z*, Xu H*..Selenium-Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a Reactive Oxygen Species (ROS)-Mediated Apoptosis Route. Chem Asian J. 2014,9(8):2295-2302.SCI
65. 14.Pun VC, Yu IT, Ho KF, Qiu H, Sun Z, Tian L*.Differential Effects of Source-Specific Particulate Matter on Emergency Hospitalizations for Ischemic Heart Disease in Hong Kong. Environ Health Perspect. 2014,122(4):391-396.SCI
66. Junchao Duan, Yongbo Yu, Yang Yu, Yang Li, Ji Wang, Weijia Geng, Lizhen Jiang, Qiuling Li, Xianqing Zhou, Zhiwei Sun*. .Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway. Int J Nanomedicine. 2014,9:5131-5141.SCI
67. Yu Y, Duan J, Yu Y, Li Y, Liu X, Zhou X, Ho KF, Tian L, Sun Z*.Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species. J Hazard Mater. 2014,15 (270):176-86.SCI
68. Yu Y, Li Y, Wang W, Jin MH, Du ZJ, Li YB, Duan JC, Yu YB, Sun ZW*. .Acute Toxicity of Amorphous Silica Nanoparticles in Intravenously Exposed ICR Mice. PLoS One. 2013,8(4): e61346.SCI
69. Shuang Jiang, Peige Du, Liping An, Guangxin Yuan, Zhiwei Sun.Anti-diabetic effect of Coptis Chinensis polysaccharide in high-fat diet with STZ-induced diabetic mice. International Journal of Biological Macromolecules. 2013,55:118-122.SCI
70. Ren H, Wu Y, Li Y, Cao W, Sun Z, Xu H, Zhang X.Visible-Light-Induced Disruption of Diselenide-Containing Layer-by-Layer Films: Toward Combination of Chemotherapy and Photodynamic Therapy. Small. 2013,9(23):3981-3986.SCI
71. Junchao Duan, Yongbo Yu, Yang Li, Yang Yu, Yanbo Li, Peili Huang, Xianqing Zhou, Shuangqing Peng, Zhiwei Sun*.Toxic effects of silica nanoparticles on zebrafish embryos and larvae. PLoS One. 2013, 8(9):e74606.SCI
72. Junchao Duan, Yongbo Yu, Yang Li, Yang Yu, Yanbo Li, Peili Huang, Xianqing Zhou, Shuangqing Peng, Zhiwei Sun*.Developmental toxicity of CdTe QDs in zebrafish embryos and larvae. J Nanopart Res. 2013,15:2-9.SCI
73. Juncaho Duan, Yongbo Yu, Yang Li, Yang Yu, Zhiwei Sun*.Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model. Biomaterials. 2013,34:5853-5862.SCI
74. Wen Wang, Yang Li, Xiaomei Liu, Minghua Jin, Haiying Du, Ying Liu, Peili Huang, Xianqing Zhou, Lan Yuan, Zhiwei Sun*.Multinucleation and cell dysfunctioninduced by amorphous silica nanoparticles in an L-02 human hepatic cell line. International Journal of Nanomedicine. 2013,8:3533-3541.SCI
75. Duan JC, Yu YB, Li Y, Yu Y, Li YB, Zhou XQ, Huang PL, Sun ZW* .Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via Chk1-dependent G2/M checkpoint. PLoS One. 2013,19(8):e62087.SCI
76. Du ZJ, Zhao DL, Jing L, Cui GQ, Jin MH, Li Y, Liu XM, Liu Y, Du HY, Guo CX, Zhou XQ, Sun ZW*. .Cardiovascular Toxicity of Different Sizes Amorphous Silica Nanoparticles in Rats After Intratracheal Instillation. Cardiovasc Toxicol. 2013,13(3):194-207.SCI
77. Na Liu, Ying Mu, Yi Chen, Hubo Sun, Sihai Han, Mengmeng Wang, Hui Wang, Yanbo Li, Qian Xu, Peili Huang* and Zhiwei Sun#.Degradation of aqueous synthesized CdTe/ZnSquantum dots in mice: differential blood kineticsand biodistribution of cadmium and tellurium. Particle and Fibre Toxicology. 2013,10(39):2-9.SCI
78. Peng Han, Sichao Li, Wei Cao, Yang Li, Zhiwei Sun, Zhiqiang Wang and Huangping Xu.Red light responsive diselenide-containing block copolymer micellest. Journal of Materials Chemistry B. 2012,1:740.SCI
79. Xin-Li Lin, Shu-Hua Zhao, Long Zhang, Gui-Qin Hu, Wen-Sheng Yang, Zhi-Wei Sun*.Dose-dependent cytotoxicity and oxidative stress induced by “naked” Fe3O4 nanoparticles in human hepatocyte. Chemial Research in Chinese Universities. 2012,28(1):114-118.SCI
80. Yanhua Wu, Jing Jia, Yanbo Li, Zhixiong Shi, Xianqing Zhou and Zhiwei Sun.Crry receptor and oxidative stress involved in erythrocyte immune toxicity of mice caused by endosulfan and protective effects of vitamin E. The Journal of Toxicological Sciences. 2012, 37(6):1225-1237.SCI
81. Yanbo Li, Caixia Guo, Zhicheng Wang, Pingsheng Gong, Zhiwei Sun*,Shouliang Gong .Enhanced effects of TRAIL-endostatin-based double-gene-radiotherapy on suppressing growth, promoting apoptosis and inducing cell cycle arrest in vascular endothelial cells. J Huazhong Univ Sci Technol. 2012,32(2):153-157.SCI
82. Yanbo Li, Haixia Zhang, Caixia Guo, Guiqin Hu, Haiying Du, Minghua Jin, Peili Huang﹡, Zhiwei Sun﹡, Wensheng Yang..Cytotoxicity and DNA damage effect of TGA-capped CdTe quantum dots.. Chem Res Chinese Universities. 2012,28(2):276-281.SCI
83. Bin Wang, Di Chen, Wei Guo, Zongwen Li, Yang Li, Xianqing Zhou, Peili Huang*, Zhiwei Sun*..Silica nanoparticles suppress fibronectin-mediated adhesion and migration in normal human keratinocytes.. Nanoscience and nanotechnology. 2012,12:293-299.SCI
84. Xin-Li Lin, Shu-Hua Zhao, Long Zhang, Gui-Qin Hu, Wen-Sheng Yang, Zhi-Wei Sun*..Dose-dependent cytotoxicity and oxidative stress induced by “naked” Fe3O4 nanoparticles in human hepatocyte. Chem Res Chinese Universities. 2012,28(1):114-118.SCI
85. 10.Peili Huang, Guojun Li, Chunxia Chen, Hui Wang, Ying Han, Shuhua Zhang, Yang Xiao, Man Zhang, Na Liu, Jinhua Chu, Long Zhang, Zhiwei Sun*..Differential toxicity of Mn(2+) and Mn(3+) to rat liver tissues: Oxidative damage, membrane fluidity and histopathological changes. Experimental and Toxicologic patholog. 2012,64(3):197-203.SCI
86. 8.Wei Cao, Yang Li, Yu Yi, Shao Ji, Lingwu Zeng, Zhiwei Sun*, and Huangping Xu.Coordination-responsive Selenium-containing Polymer Micelles for Controlled Drug Release. Chemical Science. 2012,3:3403-3408.SCI
87. Shuhua Zhao, Xinli Lin, Long Zhang, Lei Sun, Jun Li, Wensheng Yang, Zhiwei Sun*.The in vivo investigation of Fe3O4-nanoparticles acute toxicity in mice. Biomedical Engineering: Applications, Basis and Communication. 2012,24(3):229-235.SCI
88. 11.Shuhua Zhao, Xinli Lin, Long Zhang, Lei Sun, Jun Li, Wensheng Yang, Zhiwei Sun*..the in vivo investigation of Fe3O4-nanoparticles acute toxicity in mice. Biomedical Engineering: Applications, Basis and Communication. 2012,24(3):**-1-7..SCI
89. Li Y, Sun L, Jin M, Du Z, Liu X, Guo C, Li Y, Huang P*, Sun Z*..Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells.. Toxicology in vitro. 2011,25(7):1343-1352.SCI
90. 2.Xing Feng, Jing Li, Jinyu Liu, Minghua Jin, Xiaomei Liu, Haiying Du, Long Zhang, Zhiwei Sun*, Xiaoguang Li.Protective Effect of FK506 on Myocardial Ischemia/Reperfusion Injury by Suppression of CaN and ASK1 Signaling Circuitry. Cardiovasc Toxicol. 2011,(1):18-27.SCI
91. 1.Caixia Guo, Yanbo Li, Haixia Zhang, Zhicheng Wang, Minghua Jin, Long Zhang, Liping An, Guiqin Hu, Xiaomei Liu, Haiying Du, Zhiwei Sun*.Enhancement of antiproliferative and proapoptotic effects of cadmium chloride combined with hSmac in hepatocellular carcinoma cells. Chemotherapy. 2011, 57(1):27-34.SCI
92. Caixia Guo, Yanbo Li, Haixia Zhang, Zhicheng Wang, Minghua Jin, Long Zhang, Liping An, Guiqin Hu, Xiaomei Liu, Haiying Du, Zhiwei Sun*..Enhancement of antiproliferative and proapoptotic effects of cadmium chloride combined with hSmac in hepatocellular carcinoma cells.. Chemotherapy. 2011,57(1):27-34.SCI
93. Xing Feng, Jing Li, Jinyu Liu, Minghua Jin, Xiaomei Liu, Haiying Du, Long Zhang, Zhiwei Sun*, Xiaoguang Li*..Protective Effect of FK506 on Myocardial Ischemia/Reperfusion Injury by Suppression of CaN and ASK1 Signaling Circuitry.. Cardiovasc Toxicol. 2011,11(1):18-27.SCI
94. Liping An, Yapei Wang, Xiaomei Liu, Ning Ma, Haiying Du, Minghua Jin, Ying Liu, Long Zhang,Yanling Xu, Peili Huang*, Zhiwei Sun*..Block ionomer complex micelles based on the self-assembly of poly(ethylene glycol)-b-poly(acrylic acid) and CdCl2 for anti-tumor drug delivery. Chemical and Pharmaceutical Bulletin. 2011,59(5):559-563.SCI
95. Ning Ma, Huaping Xu, Liping An, Juan Li, Zhiwei Sun, Xi Zhang..Radiation-sensitive diselenide block copolymer micellar aggregates: toward the combination of radiotherapy and chemotherapy. Langmuir. 2011,27(10):5874-5878.SCI
96. Peili Huang, Chunxia Chen, Hui Wang, Guojun Li, Haiming Jing, Ying Han, Na Liu, Yang Xiao, Qiuhong Yu, Yuting Liu, Pengwen Wang, Zhixiong Shi, Zhiwei Sun*. .Manganese effects in the liver following subacute or subchronic manganese chloride exposure in rats. Ecotoxicology and Environmental Safety. 2011,74(4):615-622.SCI
97. Ying Han, Guangyun Xie, Zhiwei Sun, Ying Mu, Sihai Han, Yang Xiao, Na Liu, Hui Wang, Caixia Guo, Zhixiong Shi, Yanbo Li, Peili Huang*..Plasma kinetics and Biodistribution of Water-soluble CdTe Quantum Dots in mice: A Comparison Between Cd and Te.. Journal of Nanoparticle Research. 2011,13(10):5373-5380.SCI
98. Sun L, Li Y, Liu X, Jin M, Zhang L, Du Z, Guo C, Huang P*, Sun Z*..Cytotoxicity and mitochondrial damage caused by silica nanoparticles. Toxicol In Vitro. 2011,25(8):1619-1629.SCI
99. Guiqin Hu, Minghua Jin, Xinli Lin, Caixia Guo, Long Zhang, Zhiwei Sun*. .Mercury distribution in neonatal rat brain after intrauterine methylmercury exposure. Environmental Toxicology and Pharmacology. 2010,29(1):7-11.SCI
主编或副主编的著作/译著
1. 《毒理学基础（第7版）》,主编,人民卫生出版社,201708
2. 《毒理学实验技术与方法》,副主编,人民卫生出版社,201209
3. 《毒理学基础（第6版）》,副主编,人民卫生出版社,201208
4. 《预防医学》,主编,人民卫生出版社,201201
5. 《预防医学（第二版）》,副主编,人民卫生出版社,201003
6. 《毒理学基础（案例版）》,主编,科学出版社,200808
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