姓名：周显青 性别：女 职称：教授 招生院所：公共卫生学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：卫生毒理学(博) 卫生毒理学(硕) 研究方向名称：环境毒理学-环境化学物和纳米毒理学 电子信箱：xqzhou@ccmu.edu.cn


社会任职
个人简历
1. 198209-198607:山东师范大学生物系 攻读本科
2. 198607-199408:山东理工大学 工作
3. 199409-199707:北京师范大学生物系 攻读硕士
4. 199709-200007:北京师范大学生物系 攻读博士
5. 200008-:首都医科大学 任教
6. 200708-200711:美国系统生物研究所 访问学习
重要学术论文
1. Lianshuang Zhang# , Jialiu Wei# , Junchao Duan# , Caixia Guo , Jin Zhang, Lihua Ren, Jianhui Liu , Yanbo Li* , Zhiwei Sun, Xianqing Zhou*..Silica Nanoparticles exacerbates reproductive toxicity development in high-fat diet-treated Wistar rats. Journal of Hazardous Materials. 2020,384:121361.SCI
2. Xiangyang Li, Yupeng Zhu , Chonghai Zhang, Jianhui Liu, Guiqing Zhou, Li Jing, Zhixiong Shi , Zhiwei Sun, Xianqing Zhou*.BDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways. Environmental Pollution. 2019,255:113097.SCI
3. Yupeng Zhu, Xiangyang Li , Jianhui Liu, Guiqing Zhou, Yang Yu *, Li Jing, Zhixiong Shi, Xianqing Zhou* , Zhiwei Sun.The effects of decabromodiphenyl ether on glycolipid metabolism and related signaling pathways in mice. Chemosphere. 2019,222:849-855.SCI
4. Jianhui Liu#, Jin Zhang#, Lihua Ren, Jialiu Wei, Yupeng Zhu, Junchao Duan,Li Jing, Zhiwei Sun*, Xianqing Zhou*..Fine particulate matters induce apoptosis via the ATM/P53/CDK2 and mitochondria apoptosis pathway triggered by oxidative stress in rat and GC-2spd cell.. Ecotoxicology and Environmental Safety. 2019,180:280–287.SCI
5. Lihua Ren# , Jianhui Liu#, Jin Zhang, Ji Wang , Jialiu Wei, Yanbo Li, Caixia Guo, Zhiwei Sun , Xianqing Zhou*.Silica nanoparticles induce spermatocyte cell autophagy through microRNA-494 targeting AKT in GC-2spd cells. Environmental Pollution. 2019,255:113172.SCI
6. Jianhui Liu, Lihua Ren, Jialiu Wei, Jin Zhang, Yupeng Zhu, Xiangyang Li, Li Jing, Junchao Duan, Xianqing Zhou*, Zhiwei Sun.Fine particle matter disrupts the blood–testis barrier by activating TGF-b3/p38 MAPK pathway and decreasing testosterone secretion in rat.. Environmental Toxicology. 2018,33（7）:711-719.SCI
7. Jianhui Liu,Man Yang, Li Jing, Lihua Ren, Jialiu Wei, Feng Zhang, Junchao Duan, Xianqing Zhou*, Zhiwei Sun..Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice. Environmental Science and Pollution Research. 2018,25:3423-3434..SCI
8. Jin Zhang#, Jianhui Liu#, Lihua Ren, Jialiu Wei, Junchao Duan, Lefeng Zhang*, Xianqing Zhou*, Zhiwei Sun.PM2.5 induces male reproductive toxicity via mitoc-hondrial dysfunction, DNA damageand RIPK1 mediated apoptotic signaling pathway. Science of the Total Environment. 2018,634:1435–1444.SCI
9. Jin Zhang#, Jianhui Liu#, Lihua Ren, Jialiu Wei, Feng Zhang , Yanbo Li, Caixia Guo, Junchao Duan, Zhiwei Sun, Xianqing Zhou*.Silica nanoparticles induce abnormal mitosis and apoptosis via PKC-δ mediated negative signaling pathway in GC-2 cells of mice. . Chemosphere. 2018,208:942-950.SCI
10. Jialiu Wei, Lianshuang Zhang, Lihua Ren, Jin Zhang, Yang Yu, Ji Wang, Junchao Duan, Cheng Peng, Zhiwei Sun, Xianqing Zhou*.Endosulfan induces proliferation inhibition through Notch signaling pathway in human umbilical vein endothelial cells. Environmental Pollution. 2017,221:26-36.SCI
11. Lianshuang Zhang, Jialiu Wei ，Lihua Ren, Jin Zhang, Ji Wang，Li Jing，Man Yang，Yang Yu, Zhiwei Sun, Xianqing Zhou*.Endosulfan induces autophagy and endothelial dysfunction via the AMPK/mTOR signaling pathway triggered by oxidative stress. Environmental Pollution. 2017,220:843-852.SCI
12. Fang-Zi Guo #, Ying Xu#, Li-Hua Ren#, Jin Zhang, Feng Zhang, Junchao Duan, Xian-Qing Zhou*, Zhi-Wei Sun.Endosulfan induces apoptosis by activating the negative regulation pathway of cell cycle and death receptor pathway in spermatogenic cells. Toxicology Research. 2017,6:223-231.SCI
13. Jialiu Wei, Lianshuang Zhang, Lihua Ren, Jin Zhang, Jianhui Liu, Junchao Duan, Yang Yu,Yanbo Li, Cheng Peng, Xianqing Zhou*, Zhiwei Sun. Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways.. Science of the Total Environment. 2017,589:97–106..SCI
14. Lianshuang Zhang，Jialiu Wei，Lihua Ren，Jin Zhang，Man Yang*，Li Jing，Ji Wang，Zhiwei Sun，Xianqing Zhou*.Endosulfan inducing apoptosis and necroptosis through activation RIPK signaling pathway in human umbilical vascular endothelial cells. Environmental Science and Pollution Research. 2017,24: 215–225.SCI
15. Jianhui Liu,Man Yang, Li Jing, Lihua Ren, Jialiu Wei, Feng Zhang, Junchao Duan, Xianqing Zhou* Zhiwei Sun..Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice. Environmental Science and Pollution Research. 2017,25:3423–3434.SCI
16. Ying Xu, Na Wang, Zhi-Xiong Shi, Yan-Bo Li, Xian-Qing Zhou* and Zhi-Wei Sun.In vitro mechanistic study of endosulfan-induced spermatogenic cell apoptosis in the mouse. Toxicology and Industrial Health. 2016, 32(9):1550–1563.SCI
17. Lihua Ren, Jin Zhang, Yang Zou, Lianshuang Zhang, Jialiu Wei, Zhixiong Shi, Yanbo Li, Caixia Guo, Zhiwei Sun,Xianqing Zhou*.Silica nanoparticles induce reversible damage of spermatogenic cells via RIPK1 signal pathways in C57 mice. International Journal of Nanomedicine. 2016,11:2251–2264.SCI
18. Na Wang, Ying Xu, Xian-Qing Zhou*, Yan-Hua Wu, Sheng-Li Li, Xin Qiao, Yan-Bo Li, Zhi-Wei Sun.Protective Effects of Testosterone Propionate on Reproductive Toxicity Caused by Endosulfan in Male Mice.. Environmental Toxicology. 2016,31(2):142-153.SCI
19. Fang-Zi Guo，Lian-Shuang Zhang，Jia-Liu Wei，Li-Hua Ren，Jin Zhang，Li Jing *，ManYang，JiWang，Zhi-WeiSun，Xian-QingZhou*.Endosulfan inhibiting the meiosis process via depressing expressions of regulatory factors and causing cell cycle arrest in spermatogenic cells. Environmental Science and Pollution Research. 2016,23(20):20506-20516.SCI
20. Lianshuang Zhang, Jialiu Wei, Fangzi Guo, Junchao Duan, Yanbo Li, Zhixiong Shi, Yumei Yang, Xianqing Zhou*, Zhiwei Sun.Endosulfan activates the extrinsic coagulation pathway by inducing endothelial cell injury in rats. Environ Sci Pollut Res. 2015, 22（20）:15722-15730.SCI
21. Jia-Liu Wei, Lian-Shuang Zhang, Jing-Jing Wang, Fang-Zi Guo, Yan-Bo Li, Xian-Qing Zhou* and Zhi-Wei Sun.Endosulfan inducing blood hypercoagulability and endothelial cells apoptosis via the death receptor pathway in Wistar rats. Toxicology Research. 2015,4:1282-1288.SCI
22. Ying Xu, Na Wang, Zhi-Xiong Shi, Yan-Bo Li, Xian-Qing Zhou* and Zhi-Wei Sun.The mechanism study of endosulfan-induced spermatogenic cell apoptosis of mouse in vitro. Toxicology and Industrial Health. 2015,【未填写卷（期）】:DOI: 10.1177/7525. .SCI
23. Fang-Zi Guo, Lian-Shuang Zhang, Jia-Liu Wei, Yan-Bo Li, Zhi-Xiong Shi, Yu-Mei Yang, Xian-Qing Zhou* and Zhi-Wei Sun.Endosulfan induced the arrest of the cell cycle through inhibiting the signal pathway mediated by PKC-α and damaging the cytoskeleton in spermatogonial cells of mice in vitro. Toxicol Res. 2015,4: 508–518.SCI
24. Ying Xu, Na Wang, Yang Yu, Yang Li, Yan-Bo Li, Yong-Bo Yu, Xian-Qing Zhou*, Zhi-Wei Sun*. Exposure to Silica Nanoparticles Causes Reversible Damage of the Spermatogenic Process in Mice. PLOS ONE. 2014,9(7):http://dx.plos.org/10.1371/journal.pone.**.SCI
25. Na Wang, Ying Xu, Xian-Qing Zhou*, Yan-Hua Wu, Sheng-Li Li, Xin Qiao, Yan-Bo Li, Zhi-Wei Sun.Protective Effects of Testosterone Propionate on Reproductive Toxicity Caused by Endosulfan in Male Mice. Environmental Toxicology. 2014,【未填写卷（期）】:DOI 10.1002/tox.SCI
26. Junchao Duan,Yongbo Yu, Yang Yu, Yang Li, Ji Wang, Weijia Geng, Lizhen Jiang, Qiuling Li, Xianqing Zhou*, Zhiwei Sun*.Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway. International Journal of Nanomedicine. 2014,9:5131–5141.SCI
27. Zhongjun Du，Dali Zhao，Li Jing，Guanqun Cui，Minghua Jin， Yang Li，Xiaomei Liu，Ying Liu，Haiying Du， Caixia Guo，Xianqing Zhou*，Zhiwei Sun*.Cardiovascular Toxicity of Different Sizes Amorphous Silica Nanoparticles in Rats After Intratracheal Instillation. Cardiovasc Toxicol. 2013,13(3):194-207.SCI
28. Meng Zhang, Yan-Hua Wu, Xian-Qing Zhou*, Huan-Nv Zhou.The effects of endosulfan on the growth and erythrocyte immune function of Mongolian gerbils (Meriones unguiculatus). Immunopharmacology And Immunotoxicology. 2012, 34(5-6):754–762.SCI
29. Na Wang, Hong-YanQian, Xian-QingZhou*, Yan-BoLi, Zhi-WeiSun.Mitochondrial energy metabolism dysfunction involved in reproductive toxicity of mice caused by endosulfan and protective effects of vitamin E. Ecotoxicology and Environmental Safety. 2012,82 :96–103.SCI
30. 王娜，钱红燕，王迎，周显青*.环境激素烯菌酮引发小鼠前列腺癌细胞的毒性机制. 生态毒理学报. 2012,7（2:189-194.核心期刊
31. Hai-Ping Yin, Jian-Ping Xu, Xian-Qing Zhou*,Ying Wang.Effects of vitamin E on reproductive hormones and testis structure in chronic dioxin-treated mice. Toxicology and Industrial Health. 2012,28(2):152 - 161.SCI
32. Jing Jia#，Yan-Hua Wu#， Xian-Qing Zhou*, Ying Wang.Effects of Testosterone Propionate on Oxidative Stress and the Expression of Spleen Cytokine Genes in Endosulfan-Treated Mice. Journal of Environmental Pathology, Toxicology and Oncology. 2012,31(1):17-26.
33. Yan-Hua Wu#, Jing Jia#, Yan-Bo Li, Zhi-Xiong Shi, Xian-Qing Zhou*, Zhi-Wei Sun.Crry receptor and oxidative stress involved in erythrocyte immune toxicity of mice caused by endosulfan and protective effects of vitamin E. The Journal of Toxicological Sciences . 2012, 37 (6):1225-1237.SCI
34. 贾静, 周欢女, 周显青*.维生素E对硫丹染毒小鼠脾细胞因子基因转录的影响. 实验动物科学. 2011,28(2):15-19.核心期刊
35. 刘宇，周显青*.烯菌酮对小鼠前列腺癌细胞增殖及其脂质过氧化物含量和抗氧化物酶活性的影响. 实验动物科学. 2010,27(2:5-9.核心期刊
36. 张蒙，周显青*.硫丹对小鼠红细胞免疫功能的影响. 动物学杂志. 2010,45（1）:50-58.核心期刊
37. 尹海萍，徐建平， 杨绍华，周显青*.维生素E拮抗急性二噁英对小鼠肝脏细胞色素P450 酶和抗氧化物酶基因转录的影响. 动物学报. 2008,54（6）:1038-1043.核心期刊
38. 尹海萍，徐建平，周显青*.维生素E对2，3，7，8-四氯二苯并二悪英急性染毒小鼠卵巢内分泌及其结构的影响. 动物学研究. 2008,29（3）:265-269.核心期刊
39. 周显青*，王晓辉，徐建平，王迎，路静..维生素E对TCDD染毒小鼠白细胞介素和T细胞亚群的影响. 动物学报. 2007,53（5）:884-891.核心期刊
40. 尹海萍，徐建平，周显青*，王迎.维生素E对二噁英染毒小鼠肝脏细胞色素P450酶基因转录的影响. 中国比较医学杂志. 2007,17（12）:683-688.核心期刊
41. 藤旭，武文琦，周显青*. 维生素C多聚磷酸酯对小鼠肝脏抗氧化物酶基因转录的影响. 动物学报. 2006,52（6）:1107 – 1112.核心期刊
42. Xianqing Zhou, Cuijuan Niu*, Ruyong Sun.The effects of vitamin E on non-specific immune response of the juvenile soft-shelled turtle Pelodiscus sinensis . Fisheries Science. 2005,71(3):612-617.SCI
43. 王晓辉，李胜利，乔欣，盖新娜，陈 怡，周显青*.维生素C多聚磷酸酯对小鼠生长、淋巴细胞转化以及血清皮质酮含量的影响. . 中国实验动物学报. 2005,13（3）:176-179 .核心期刊
44. Xianqing Zhou, Cuijuan Niu*, Ruyong Sun.The effect of Vitamin C on stress withstanding capability in the juvenile soft-shelled turtle (Pelodiscus sinensis ). Aquaculture Nutrition. 2005,11(3):169-174.SCI
45. Xianqing Zhou, Cuijuan Niu*, Ruyong Sun..The effects of vitamin E on anti-acid stress ability in juvenile soft-shelled turtles（Pelodiscus sinensis）. Comparative Biochemistry and Physiology，Part C. 2004,137(4):299-305.SCI
主编或副主编的著作/译著
重要奖项
1. 首都医科大学学术拔尖人才 201107
2. 北京市优秀人才称号和资助（A类） 200611
3. 北京市中青年骨干教师称号和资助 200605
4. 北京市丰台区科学技术奖 二等、第一 2005
5. 北京市优秀科技论文奖 三等、第一 2003
6. 国际工程技术教育基金会博士研究生奖 200007
7. 北京师范大学优秀研究生奖 199907