徐柏玲

徐柏玲 学位：博士， 职称：研究员 博士生导师
联系电话：，邮箱： xubl@imm.ac.cn

教育背景
1992年毕业于东北师范大学化学系，获学士学位；1995年毕业于东北师范大学有机化学专业，获硕士学位；1998年毕业于中国医学科学院，中国协和医科大学药物研究所药物化学专业，获博士学位。

工作经历
1998年9月至2000年10月工作于药物研究所，任助理研究员。2000年11月到美国加洲大学戴维斯癌症研究中心做博士后，从事固相组合化学研究。2002年3月到弗吉尼亚理工大学做博士后，从事肽模拟物的设计与合成工作。2004年2月回到药物所工作，先后任助理研究员、副研究员和研究员。

专业研究方向领域
药物分子设计与合成

承担的课题
1. PARP1抑制剂的设计、合成和抗肿瘤活性研究
2. FBPase抑制剂的设计、合成和抗糖尿病药物研究
3. Pin1小分子抑制剂的设计、合成及生物功能研究
4. 靶向钾离子通道Kv2.1选择性阻断剂的设计、合成及生物功能研究

近年发表论文
1. Hailong Zhao#, Ming Ji#, Guonan Cui, Jie zhou, Fangfang Lai, Xiaoguang Chen^*, Bailing Xu^* Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors, Bioorgnic Medicinal Chemistry 2017, online.
2. Jie Zhou#, Ming Ji#, Zhixiang Zhu, Ran Cao, Xiaoguang Chen^*, Bailing Xu*, Discovery of 2-substituted 1H-benzo[d]imidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity, European Journal of Medicinal Chemistry, 2017, 132, 26-41.
3. Hailong Zhao#, Guonan Cui#, Jing Jin, Xiaoguang Chen^*, Bailing Xu^*, Synthesis and Pin1 inhibitory activity of thiazole derivatives, Bioorgnic Medicinal Chemistry 2016, 24, 5911-5920.
4. Haiping Yao#, Ming Ji# , Zhixiang Zhu, Jie zhou, Ran Cao, Xiaoguang Chen^*, Bailing Xu^* Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors, Bioorgnic Medicinal Chemistry 2015, 23, 681-693.
5. Jianbo Bie#, Shuainan Liu# , Zhanmei Li, Yongzhao Mu, Bailing Xu* , Zhufang Shen*, Discovery of novel indole derivatives as allosteric inhibitors of fructose-1, 6-bisphosphatase, European Journal of Medicinal Chemistry, 2015, 90, 394-405.
6. Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu*, Zhufang Shen*, Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase, Bioorgnic Medicinal Chemistry 2014, 22, 1850-1862.
7. Jie Zhou,# Mingyu Ba#, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu*, Ying Guo*, Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors, Med. Chem. Commun., 2014, 5, 441-444
8. Jie Zhou#, Jing Jin# , Yi Zhang, Yuwen, Yin, Xiaoguang Chen*, Bailing Xu*, Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4, European Journal of Medicinal Chemistry, 2013, 68, 222-232.
9. Chang Liu#, Jing Jin#, Liang Chen, Jie Zhou, Xiaoguang Chen*, Decai, Fu, Hongrui Song, Bailing Xu*. Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg. Med. Chem. 2012, 20, 2992-2999.
10. Lina Zhu#, Jing Jin#, Chang Liu, Chongjin Zhang, Yan Sun, Yanshen Guo, Decai Fu, Xiaoguang Chen*, Bailing Xu*. Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors. Bioorgnic Medicinal Chemistry 2011, 19(9), 2797-2807.
11. Jie Zhou#, Yi Zhang#, Yiwen Cui, Zhanmei Li, Hongrui Song, Jinhua Dong, Xiaoguang Chen*, Bailing Xu*. Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)- arylsulfonamide and N-aryl-(4-methoxy- 1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastin A-4. Journal of Asian Natural Products Research 2011, 13(4), 330-340.