李莉

李莉 博士，研究员，博士生导师
教育背景
1993年9月-1997年7月 北京师范大学化学系 化学专业 本科
1997年9月-2002年6月 中国医学科学院放射医学研究所 影像医学与核医学专业 博士
联系方式
电话：
E-mail: annaleelin@imm.ac.cn
工作经历
2002年7月-2004年6月 中国医学科学院药物研究所 药学专业 博士后
2004年7月至今 中国医学科学院药物研究所副研究员，研究员
专业研究领域
1. 手性光谱学的基础与应用研究，包括天然产物和手性药物的立体结构表征、不对称反应的过程分析、手性传感体系的构建与应用、生物大分子的空间结构与相互作用研究；
2. 手性药物的研发，主要针对肿瘤和神经退行性疾病。
近年来主要论文
1. Wen-Qiang Liu, Fang-Fang Lai, Jie Zhang, Li Sheng, Yan Li, Li Li*, Xiao-Guang Chen*. Chiral resolution, absolute configuration determination, and stereo-activity relationship study of the IDO1 inhibitor NLG919. Tetrahedron, 2018, 74 (24), 3045-3051.
2. Guozhu Su, Shungang Jiao, Ruifei Zhang, Li Li*, Suyile Chen, Pengfei Tu, Xingyun Chai*. Alashinol H, an epoxylignan with an unusual six-membered cyclic hemiacetal from Syringa pinnatifolia. Tetrahedron Letters, 2018, 59, 1356-1359.
3. Zhiguo Liu, Xilong Zheng, Yanan Wang, Mengyue Tang, Shilin Chen, Fangbo Zhang, Li Li,* Cun Zhang*, Yi Sun*. Lignans and isoflavonoids from the stems of Pisonia umbellifera. RSC Advances, 2018, 8, 16383-16391.
4. Bo Li, Jie Zhang, Bei-Bei Yang, Li Li*, Xiao-Xiao Yang*. Ring-locking strategy facilitating determination of absolute optical purity of 2-amino-1-butanol by reverse-phase high-performance liquid chromatography. RSC Advances, 2017, 7, 45714-45720.
5. Xiang Zhang, Ming-Chao Wang, Li Li*, Da-Li Yin*. A high-performance liquid chromatography-electronic circular dichroism online method for assessing the absolute enantiomeric excess and conversion ratio of asymmetric reactions. Scientific Reports, 2017, 7: 43278.
6. Bo Li, Jie Zhang, Yongjuan Xu, Xiaoxiao Yang*, Li Li*. Improved synthesis of unnatural amino acids for peptide stapling. Tetrahedron Letters, 2017, 58(24): 2374–2377.
7. Qian Li, An-Jun Deng, Li Li*, Lian-Qiu Wu, Ming Ji, Hai-Jing Zhang, Zhi-Hong Li, Lin Ma, Zhi-Hui Zhang, Xiao-Guang Chen, and Hai-Lin Qin*. Azacyclo-indoles and Phenolics from the Flowers of Juglans regia. Journal of Natural Products, 2017, 80, 2189-2198.
8. An-Jun Deng, Hai-Jing Zhang, Qian Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu, Li Li*, Hai-Lin Qin*. Six scalemic mixtures of 6-monosubstituted dihydrobenzophenanthridine alkaloids from Chelidonium majus and optically active structures of enantiomers. Phytochemistry, 2017, 14, 159-170.
9. Junjie Han*, Congcong Liu*, Li Li*, Hui Zhou, Li Liu, Li Bao, Qian Chen, Fuhang Song, Lixin Zhang, Erwei Li, Ling Liu, Yunfei Pei, Cheng Jin, Yanfen Xue, Wenbing Yin, Yanhe Ma, Hongwei Liu. Decalin-Containing Tetramic acids and 4-hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). The Journal of Organic Chemistry, 2017, 82, 11474-11486.
10. Wan Gao, Jia-Wen Hu, Wei-Zhen Hou, Fang Xu, Jun Zhao, Fang Xu, Hua Sun, Jian-Guo Xing, Ying Peng, Xiao-Liang Wang, Teng-Fei Ji*, Li Li*, Zheng-Yi Gu*. Four new prenylated phloroglucinol derivatives from Hypericum scabrum. Tetrahedron Letters, 2016, 57(21): 2244–2248.
11. Xu Yin, Ruifeng Bai, Qiang Guo, Guozhu Su, Jing Wang, Xinyao Yang, Li Li*, Pengfei Tu, Xingyun Chai*. Hendersine A, a novel isoquinoline alkaloid from Corydalis hendersonii. Tetrahedron Letters, 2016, 57(43): 4858–4862.
12. Jian-Bo Yang^#, Li Li^#, Zhong Dai, Yu Wu, Xing-Chao Geng, Bo Li, Shuang-Cheng Ma, Ai-Guo Wang, Ya-Lun Su. Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb. Journal of Asian Natural Products Research, 2016, 18(9): 813-822.
13. Ke Ma^#, Li Li^#, Li Bao, Luwei He, Chen Sun, Bing Zhou, Shuyi Si, Hongwei Liu. Six new 3,4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXRbb. Tetrahedron, 2015, 71(12): 1808-1814.
14. Li Li, Lin Wang, Yi-Kang Si. Electronic circular dichroism behavior of chiral Phthiobuzone. Acta Pharmaceutica Sinica B, 2014, 4(2), 167-171.
15. Li Li, Bei-Bei Yang, Yi-Kang Si. Chiroptical properties of artemisinin and artemether investigated using time-dependent density functional theory. Chinese Chemical Letters, 2014, 25, 1586-1590.
专利
1. 周柔丽，刘刚，李茂进，李莉，单毅，王琳，杨华。乙二醛基双缩氨基硫脲类化合物的新用途，公开号：CN。
2. 冯志强，陈晓光，李燕，尹桂林，金小峰，李莉。含噻唑环的丙炔酰胺类衍生物及其制法和药物组合物与用途。申请号：9.0。
3. 冯志强，陈晓光，李燕，王景静，金小峰，李莉。含噁唑环的丙炔酰胺类衍生物及其制法和药物组合物与用途。申请号：3.6。
4. 冯志强，王景静，李莉。偶氮苯衍生物及其制法和药物组合物与用途。申请号：5.0。
5. 冯志强，陈晓光，李燕，王景静，周婉琪，郑若男，李莉。苯并噁唑衍生物及其制法和药物组合物与用途。申请号：2.1。
6. 李莉，王琳，张丹，鲍秀琦，高琦，臧彩霞，郑远鹏。香豆素曼尼希碱及其在防治神经退行性疾病中的用途。申请号：5.8。
7. 李莉，刘文强，张洁，杨蓓蓓。1-环己基-2-(5H-咪唑[5,1-a]异吲哚)乙基-1-酮的拆分。申请号：2.5。
8. 李莉，张洁，李博，杨蓓蓓，熊斐，陶登，刘文强，卢家民。一种识别氨基酸及肽类化合物绝对构型和光学纯度的方法。申请号：5.8。