林生

一．基本情况
林生，广东阳江人，1978年10月出生，博士，研究员，博士研究生导师，国家优秀青年科学基金获得者，入选“北京市优秀人才”和北京协和医学院“协和新星”，现任世界中医药学会联合会中药上市后再评价专业委员会青年工作委员会副主任委员、北京中医药学会临床合理用药评价专业委员会副主任委员、中华中医药学会青年工作委员会委员；Chin. Chem. Lett.，Acta Pharm. Sin. B，《中国天然药物》、《药学学报》青年编委和《中国中药杂志》编委。
联系电话：，E-mail: lsznn@imm.ac.cn.

二．教育与工作经历

1997.9 -2001.7：北京中医药大学，本科
2001.9 -2004.7：中国中医科学院，中药研究所，获医学硕士学位
2004.9 -2007.7：中国医学科学院北京协和医学院，药物研究所，获理学博士学位
2007.9 -2009.7：上海解放军第二军医大学博士后流动站
2009.9 -至今：中国医学科学院北京协和医学院，药物研究所
2015.9-2016.8：美国加州大学，Santa Cruz分校访问

三．专业研究领域

1. 中药药效物质的化学研究。
2. 中药内生真菌活性代谢产物的研究。
以活性跟踪为导向，利用多种现代色谱和波谱技术，紧密结合现代药理学和药效学评价，快速寻找发现传统中药及其内生真菌的活性成分，同时开展活性化合物进行结构衍生化及构效研究。先后参与承担自然科学基金优秀青年资金项目、 “十二五”和“十三五”重大专项等多项国家级研究项目。近年来，在国内外重要刊物Chem. Commun., Org. Lett., J. Nat. Prod. 等发表研究论文113篇，其中SCI收录的论文70余篇。申请专利16项，参编专著5部。研究工作获得了2014年北京市技术奖一等奖（排名第十）、教育部科技进步奖二等奖（排名第十）和中华医学科技奖二等奖（排名第十）。

四、主持的课题

?国家自然科学基金面上项目
?国家自然科学基金优秀青年科学基金
?国家自然科学基金青年科学基金
?天然药物活性物质与功能国家重点实验室优秀青年基金

五、代表性论文：

1. Ya-Nan Wang^#, Gui-Yang Xia^#, Ling-Yan Wang, Guang-Bo Ge, Hua-Wei Zhang, Jing-Fang Zhang, Yu-Zhuo Wu, Sheng Lin*. Purpurolide A, 5/5/5 Spirocyclic Sesquiterpene Lactone in Nature from the Endophytic Fungus Penicillium purpurogenum. Org. Lett., 2018, DOI: 10.1021/acs.orglett.8b03323.
2. Yu-Zhuo Wu^#, Hua-Wei Zhang^#, Zhao-Hui Sun, Jun-Gui Dai, You-Cai Hu, Rui Li, Peng-Cheng Lin,Gui-Yang Xia, Ling-Yan Wang, Bo-Lin Qiu, Jing-Fang Zhang, Guang-Bo Ge*, Sheng Lin*. Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities. Eur. J. Med. Chem., 2018, 145:717-725.
3. Rui Li^#, Jing-Fang Zhang^#, Yu-Zhuo Wu, Yan-Cheng Li, Gui-Yang Xia, Ling-Yan Wang, Bo-Lin Qiu, Min Ma, Sheng Lin*. Structures and Biological Evaluation of Monoterpenoid Glycosides from the Roots of Paeonia lactiflora. J. Nat. Prod., 2018, 81:1252-1259.
4. Sheng Lin, Yu-Zhuo Wu, Ke-Yv Chen, Ji Ye, Xian-Wen Yang, Wei-Dong Zhang*, Polyketides from the fungus Penicillium decumbens. J. Asian Nat. Prod. Res., 2018, 20: 445-450.
5. Peng-Cheng Lin, Yu-Zhuo Wu, Ting-Wen Bao, Ya-Nan Wang, Xiao-Ya Shang*, Sheng Lin*. A new cytotoxic 12-membered macrolactone from the endophytic fungus Exserohilum rostratum LPC-001. J. Asian Nat. Prod. Res., 2018, (doi.org/10.1080/**.2018.**).
6. Ling-Yan Wang, Ye Tian, Yu-Hong Qu, Yu-Zhuo Wu, Yan-Cheng Li, Rui Li, Peng-Cheng Lin, Xiao-Ya Shang*, Sheng Lin*. Two new terpenoid ester glycosides from the twigs of Litsea cubeba. J. Asian Nat. Prod. Res., 2018, (doi.org/10.1080/**.2018.**).
7. Ling-Yan Wang#, Ming-Hua Chen#, Jiang Wu, Hua Sun, Wei Liu, Yu-Hong Qu,Yan-Cheng Li, Yu-Zhuo Wu, Rui Li,Dan Zhang, Su-Juan Wang, Sheng Lin*. Bioactive Glycosides from the Twigs of Litsea cubeba. J. Nat. Prod., 2017, 80:1808-1818.
8. Wendi Wei^#, Sheng Lin^#, Minghua Chen, Tianxi Liu, Ali Wang, Jinjie Li, Qinglan Guo, Xiaoya Shang*. Monascustin, an Unusual γ-Lactam from Red Yeast Rice. J. Nat. Prod., 2017, 80:201-204.
9. Sheng Lin^#, Erin P. McCauley^#, Nicholas Lorig-Roach, Karen Tenney, Cassandra N. Naphen, Ai-Mei Yang, Tyler A. Johnson, Thalia Hernadez, Ramandeep Rattan, Frederick A. Valeriote, Phillip Crews*. Another Look at Pyrroloiminoquinone Alkaloids—Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues. Mar. Drugs, 2017,15:98.
10. Peng-Cheng Lin, Jing Yao, Jiang Wu, Jin Tian, Yi Bao, Sheng Lin*. A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea. Chin. Chem. Lett., 2017,28:257-259.
11. Sheng Lin, Peng Fu, Tao Chen, Ji Ye, Xian-Wen Yang, Wei-Dong Zhang*. Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity. J. Asian Nat. Prod. Res., 2017,19(1):15–21.
12. Lin Sheng^#, Ji Ye^#, Xu Liang, Xi Zhang, Juan Su, Peng Fu, Di-Ya Lv, Lei Shan, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Wei-Dong Zhang*. Mass spectrometric profiling of valepotriates possessing various acyloxy groups from Valeriana jatamansi. J. Mass Spectrom., 2015,50:1294–1304.
13. Sheng Lin, Peng Fu Tao Chen, Ji Ye, Yong-Qing Su, Xian-Wen Yang, Zhong-Xiao Zhang, Wei-Dong Zhang*. Minor Valepotriates from Valeriana jatamansi and Their Cytotoxicity against Metastatic Prostate Cancer Cells. Planta Med., 2015,81:56–61.
14. Sheng Lin, Ke-Yv Chen, Peng Fu, Ji Ye, Yong-Qing Su, Xian-Wen Yang, Zhong- Xiao Zhang, Lei Shan, Hui-Liang Li, Yun-Heng Shen, Run-Hui Liu, Xi-Ke Xu, Wei- Dong Zhang*. Structure determination of two unusual C25 steroids with bicyclo[4.4.1]A/B rings from Penicillium decumbens by NMR spectroscopy. Magn. Reson. Chem., 2015,53:223–226.
15. Sheng Lin, Tao Chen, Peng Fu, Ji Ye, Xian-Wen Yang, Lei Shan, Hui-Liang Li, Run-Hui Liu, Yun-Heng Shen, Xi-Ke Xu, Wei-Dong Zhang*. Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity. J. Asian Nat. Prod. Res., 2015,17:455–461.
16. Sheng Lin, Zhong-Xiao Zhang, Tao Chen, Ji Ye, Wei-Xing Dai, Lei Shan, Juan Su, Yun-Heng Shen, Hui-Liang Li, Run-Hui Liu, Xi-Ke Xu, Hui Wang*, Wei-Dong Zhang*. Characterization of chlorinated valepotriates from Valeriana jatamansi. Phytochemistry, 2013, 85:185-193.
17. Fang Wang, Yue-Ping Jiang, Xiao-Liang Wang, Su-Juan Wang, Peng-Bin Pu, Sheng Lin*, Cheng-Gen Zhu, and Jian-Gong Shi*. Aromatic glycosides from the flower buds of Lonicera japonica. J. Asian. Nat. Prod. Res. 2013, 15: 492-501.
18. Peng-Bin Pu, Yan-Ru Li, Ming Jiang, Fang Wang, Xiao-Liang Wang, Sheng Lin*, Cheng-Gen Zhu, and Jian-Gong Shi*. Glycosides from the Bark of Machilus robusta. J. Asian. Nat. Prod. Res. 2013, 15: 482-491.
19. Ming-Tao Liu, Sheng Lin*, Mao-Luo Gan, Ming-Hua Chen, Li Li, Su-Juan Wang, Jia-Chen Zi, Xiao-Na Fan, Ying Liu, Yi-Kang Si, Yong-Chun Yang, Xiao-Guang Chen, and Jian-Gong Shi*. Yaoshanenolides A and B: new spirolactones from the bark of Machilus yaoshansis. Org. Lett., 2012, 4:1004-1007.
20. Mao-Luo Gan, Ming-Tao Liu, Li-She Gan, Sheng Lin*, Bo Liu, Yan-Ling Zhang, Jia-Chen Zi, Wei-Xia Song, Jian-Gong Shi*. Dammarane glycosides from the Root of Machilus yaoshansis. J. Nat. Prod. 2012, 75: 1373-1382.
21. Sheng Lin, Yan-Ling Zhang, Ming-Tao Liu, Jia-Chen Zi, Mao-Luo Gan, Wei-Xia Song, Xiao-Na Fan, Su-Juan Wang*, Yong-Chun Yang, and Jian-Gong Shi*. Methoxylated fatty acids from the bark of Fraxinus sieboldiana. J. Asian. Nat. Prod. Res. 2012, 14:235-243.
22. Ming-Tao Liu, Sheng Lin*, Mao-Luo Gan, Bo Liu, Jia-Chen Zi, Wei-Xia Song, Yang-Ling Zhang, Xiao-Na Fan, Ying Liu, Wei Tan, Su-Juan Wang, Yong-Chun Yang, and Jian-Gong Shi*. Butanolide derivatives bark of Machilus yaoshansis. J. Asian. Nat. Prod. Res. 2012, 14:713-720.
23. Sheng Lin, Ting Shi, Ke-Yv Chen, Zhong-Xiao Zhang, Lei Shan, Yun-Heng Shen, and Wei-Dong Zhang. Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens. Chem. Commun., 2011, 47, 10413-10415.
24. Mao-Luo Gan, Ming-Tao Liu, Bo Liu, Sheng Lin*, Yan-Ling Zhang, Jia-Chen Zi, Wei-Xia Song, Fei Ye, Xiao-Guang Chen and Jian-Gong Shi*. Cucurbitane glucosides from the root of Machilus yaoshansis, J. Nat. Prod. 2011, 74: 2431-2437.
25. Sheng Lin, Yang-Lin Zhang, Ming-Tao Liu, Jia-Chen Zi, Mao-Luo Gan, Wei-Xia Song, Xiao-Na Fan, Su-Juan Wang, Yong-Chun Yang, and Jian-Gong Shi*. Two new ar-bisabol sesquiterpenes from the stem bark of Fraxinus sielboldiana. Acta Pharmaceutica Sinica B, 2011, 1:89-92.
26. Sheng Lin, Yangling Zhang, Mingtao Liu, Sen Yang, Maoluo Gan, Jiachen Zi, Weixia Song, Xiaona Fan, Sujuan Wang, Yang Liu, Yongchun Yang, Xiaoguang Chen, Ying Guo, Wenjie Wang and Jiangong Shi*. Abietane and C₂₀-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. J. Nat. Prod. 2010, 73: 1914-1921.
27. Sheng Lin, Yun-Heng Shen, Zhong-Xiao Zhang, Hui-Liang Li, Lei Shan, Run-Hui Liu, Xi-Ke Xu, and Wei-Dong Zhang*. Revision of the structures of 1,5-dihydroxy-3,8-epoxyvalechlorine, volvaltrate B, and valeriotetrate C from Valeriana jatamansi and V. officinalis. J. Nat. Prod. 2010, 73: 1723-1726.
28. Sheng Lin, Tao Chen, Xiao-Hua Liu, Yun-Heng Shen, Hui-Liang Li, Lei Shan, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang* and Hui Wang*. Iridoids and lignans from Valeriana jatamansi. J. Nat. Prod. 2010, 73: 632-638.
29. Sheng Lin, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Tao-Chen, Long-Hai Lu, Zheng-Sheng Huang, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang* and Hui Wang*. Acylated iridoids with cytotoxicity from Valeriana jatamansi. J. Nat. Prod. 2009, 72: 650-655.
30. Sheng Lin, Sujuan Wang, Mingtao Liu, Maoluo Gan, Shuai Li, Yongchun Yang, Yinghong Wang, Wenyi He and Jiangong Shi*. Glycosides from the bark of Fraxinus sielboldiana. J. Nat. Prod. 2007, 70: 817-823.
*corresponding author； ^# equal contribution
六、参编著作：
《天然药物化学研究》（方起程主编，中国协和医科大学出版社，2006年）；
《功能海洋生物分子－发现与应用》（谭仁祥主编，科学出版社，2007年）；
《木脂素化学》（石建功主编，化学工业出版社，2010年）
《10000个科学难题》-医学卷（科学出版社，2011年）
《天然药物化学》（科学出版社，“十三五”教材，2017年）