方莲花

方莲花 博士，研究员，博士生导师。现任中国医学科学院北京协和医学院药物研究所药物筛选中心靶点、模型、活性筛选课题组组长。兼任中国药理学会理事、中国晶体学会药物晶体学专业委员会委员、北京市药理学会心脑血管专业委员会委员、北京市药学会应用与转化药学专业委员会；国家自然科学基金、北京市、天津市、浙江省等自然科学基金评审专家；教育部学位与研究生教育评估专家；《中国药学杂志》、《中国实验动物学报》、《中国比较医学杂志》和《药学研究》等学术期刊编委。

教育背景
1985年毕业于沈阳药科大学药学系，获学士学位；1997~2002年在韩国忠北国立大学医科大学药理学专业学习，先后获医学硕士学位、博士学位。

工作经历
1985年7月开始在吉林省延边大学医学院附属医院药剂科工作，任药师、主管药师。2004年开始在中国医学科学院北京协和医学院药物研究所药物筛选中心工作，先后任助理研究员、副研究员和研究员。

专业研究领域
专业研究领域为心脑血管药理学与新药发现，重点研究以心脑血管疾病为主的新药高通量筛选的药物靶点的确认、筛选模型的建立、筛选技术的研究，尤其是通过高通量筛选获得的活性化合物的深入评价及作用机制研究。多年来从事血管功能相关细胞内信号转导通路及药物干预的研究以及防治肺动脉高压、高血压、动脉粥样硬化和糖尿病血管病变相关创新药物的研究。
主持完成了“十二五”国家科技重大专项-候选药物研究项目1项、国家自然科学基金委面上项目1项、教育部留学回国人员启动基金1项，承担多项“十一五”国家科技重大专项子课题及科技部科技基础性工作专项重点项目子课题等，参加科技部、教育部、卫生部、国家自然科学基金委、北京市科委等10余项重大、重点项目的研究工作，正在承担国家自然科学基金委面上项目2项、“十三五”国家科技重大专项-临床前研究任务1项、中国医学科学院医学与健康科技创新工程项目任务1项。

发表论著，获奖情况，专利
参与完成1.1类抗脑卒中新药-匹诺塞林注射液及1.1类抗帕金森新药-百可利的临床前研究。发表论文共100余篇，其中SCI收录论文近50篇，申请国家专利13项，授权9项。参与编写编译《应用分子药理学》（第2版）、《新药研究与评价概论》、《药理学原理》和《药理实验方法学（第四版）》等14部著作。获得2009年北京市科学技术贰等奖、2011年中华医学科技叁等奖和2017年中华医学科技叁等奖。
发表论著
[1] Chen Yu-Cai, Yuan Tian-Yi, Zhang Hui-Fang, Yan Yu, Wang Dan-Shu, Fang Lian-Hua*, Lu Yang, Du Guan-Hua*. Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition: An insight from a plant polyphenol. Int J Biol Sci, 2017 Sep, 13(8): 1067-1081.
[2] Yuan Tian-Yi, Chen Yu-Cai, Zhang Hui-Fang, Fang Lian-hua*, Du Guan-hua*. Salvianolic acid A, a component of Salvia Miltiorrhiza, attenuates endothelial- mesenchymal transition of HPAECs induced by hypoxia. Am J Chin Med, 2017; 45(6): 1185-1200.
[3] Yuan Tian-Yi, Zhang Hui-Fang, Chen Yu-Cai, Jiao Xiao-Zhen, Xie Ping, Fang Lian-hua*, Du Guan-hua*. The Protective Effect of DL0805 derivatives on pulmonary artery cells and the underlying mechanisms study. Current Vasc Pharmacol. 2017 Jul: 15(5): 469-476.
[4] Yan Yu, Zhang Hui-Fang, Zhang Zhi-Hui, Song Jun-Ke, Chen Yu-Cai, Wang Xiao-Bo, He Yang-Yang, Qin Hai-Llin, Fang Lian-Hua*, Du Guan-Hua*. Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography-mass spectrometry. Biomed Chromatogr. 2017 Jul; 31(7): e3918.
[5] Lin Yi-Huang, Yan Yu, Zhang Hui-Fang, Chen Yu-Cai, He Yang-Yang Wang Shou-Bao, Fang Lian-Hua*, Lu Yang, Du Guan-Hua*. Salvianolic acid A alleviates renal injury against the systemic lupus erythematosus induced by pristane in BALB/c mice. Acta Pharm Sin B. 2017 Mar; 7(2): 159-166.
[6] Chen Yu-cai, Yuan Tian-yi, Zhang Hui-fang, Wang Dan-shu, Niu Zi-ran, Li Li, Fang Lian-hua*, Du Guan-hua*. Fasudil evokes vasodilatation of rat mesenteric vascular bed via Ca²⁺ channels and Rho/ROCK pathway. Eur J Pharmacol. 2016, Oct; 788: 226-233.
[7] Chen Yu-cai, Yuan Tian-yi, Zhang Hui-fang, Wang Dan-shu, Yan Yu, Niu Zi-ran, Lin Yi-huang, Fang Lian-hua*, Du Guan-hua*. Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model. Acta Pharmacol Sin. 2016, 37(6): 772-782.
[8] Yuan Tian-yi, Chen Yu-cai, Zhang Hui-fang, Li Li, Jiao Xiao-zhen, Xie Ping, Fang Lian-hua*, Du Guan-hua*. DL0805-2, a novel indazole derivative, relaxes Angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes. Acta Pharmacol Sin. 2016, 37(5): 604-616.
[9] Yan Yu, Chen Yu-cai, Lin Yi-huang, Guo Jing, Niu Zi-ran, Li Li, Wang Shou-bao, Fang Lian-hua*, Du Guan-hua*. Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and independent relaxation of rat aortic rings. Acta Pharmacol Sinica. 2015 Oct; 36(11): 1318-1326.
[10] Yuan Tian-Yi, Yan Yu, Wu Yu-Jie, Xu Xiao-Na, Li Li, Jiao Xiao-Zhen, Xie Ping, Fang Lian-Hua*, Du Guan-Hua*. Vasodilatory effect of a novel Rho-kinase inhibitor, DL0805-2, on the rat mesenteric artery and its potential mechanisms. Cardiovasc Drugs Ther. 2014 Oct; 28(5): 415-424.
[11] Guo Jing, Wang Shou-Bao, Yuan Tian-Yi, Wu Yu-Jie, Yan Yu, Li Li, Xu Xiao-Na, Gong Li-li, Qin Hai-lin, Fang Lian-Hua*, Du Guan-Hua*. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 2013, 231:384-391.
[12] Guo Jing, Li Li, Wu Yu-Jie, Yan Yu, Xu Xiao-Na, Wang Shou-Bao, Yuan Tian-Yi, Fang Lian-Hua*, Du Guan-Hua*. Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. Am J Chin Med. 2013, 41(6): 1283-1296.
[13] Gong Li-Li, Fang Lian-Hua*, Wang Su-Bo, Sun Jia-Lin, Qin Hai-Lin, Li Xiao-Xiu, Wang Shou-Bao, Du Guan-Hua*. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 2012, 222(1): 50-58.
[14] Gong Li-Li, Peng Jian-Hao, Fang Lian-Hua*, Xie Ping, Si Kun, Jiao Xiao-Zhen, Wang Li-Ping, Du Guan-Hua*. The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta. Molecules. 2012, 17(5): 5935-5944.
[15] Gong Li-Li, Fang Lian-Hua*, Qin Hai-Lin, Lv Yang, Du Guan-Hua*. Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings. Am J Chinese Med. 2012, 40(2): 309-320.