彭英

彭英 博士，研究员，博士生导师。

教育背景
1989.9-1994.7 河北医学院临床医学专业，获学士学位
1996.9-1999.7 华西医科大学药理学专业，获硕士学位
2001.9-2004.7 中国医学科学院药物研究所药理学专业，获博士学位

工作经历
1994.9-1996.7 河北省唐山市钢铁公司职工医院，内科医生
1999.9-2001.7 中国医学科学院药物研究所，研究实习员
2004.9-2008.4 哈佛大学医学院，Brigham and Women’s Hospital神经疾病中心，博士后、讲师
2008.4-2009.10 中国医学科学院药物研究所，助理研究员
2009.10-2015.9 中国医学科学院药物研究所，副研究员
2015.10- 中国医学科学院药物研究所，研究员

联系方式
Email：ypeng@imm.ac.cn
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专业研究领域
主要从事神经退行性疾病，特别是阿尔茨海默氏病的发病机制及创新药物研究。从分子、细胞及动物水平建立阿尔茨海默氏病药物筛选及评价模型并进行创新药物的筛选、评价。已获得国内、国际授权专利19项。近年来主持多项科研项目，包括国家自然基金、国家“十一五”、“十二五”重大新药创制科技重大专项基金，北京市自然科学基金、教育部留学人员科研启动基金等。获得了2010年度教育部“新世纪优秀人才支持计划”项目的资助。近年来发表论文40余篇，参与7部论著的编写。2012年获得中华医学会科技进步二等奖和北京市科技进步三等奖。目前担任中国药理学会生化与分子药理专业委员会、神经精神药理专业委员会以及国家新药开发工程技术研究中心工程技术委员会委员、北京药理学会理事及《药学学报》青年编委。

近年发表的论文：（2012- ）
1. Zhang Y, Huang LJ, Shi S, Xu SF, Wang XL*, Peng Y*. L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer’s Disease. CNS Neurosci Ther. CNS Neurosci Ther. 2016 Jul 20. doi: 10.1111/cns.12594.
2. Wang R, Chen R, Li J, Liu X, Xie K, Chen D, Peng Y*, Dai J*. Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase. J Nat Prod. 2016 Jul 28.
3. Gao W, Hou WZ, Zhao J, Xu F, Li L, Xu F, Sun H, Xing JG, Peng Y, Wang XL, Ji TF*, Gu ZY*. Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum. J Nat Prod. 2016 Jun 9.
4. Ouyang GQ, Li CJ, Yang JZ, Ma J, Li L, Peng Y, Wang XL, Zhang DM*. Limonoids with neuroprotective activity from the stems of Clausena emarginata. J Asian Nat Prod Res. 2016 Jun 8:1-10.
5. Wang F, Ma J, Han F, Guo X, Meng L, Sun Y, Jin C, Duan H, Li H*, Peng Y*. DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. Sci Rep. 2016 Jan 13;6:19396.
6. Zhao CY Lei H, Zhang Y, Li L, Xu SF, Cai J, Wang XL*, Peng Y*. L-3-n-butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and up-regulates Heme oxygenase-1 in lipopolysaccharide-treated mice. J Asian Nat Prod Res. 2016; 18(3):289-302.
7. Wang L, Cheng S, Yin Z, Xu C, Lu S, Hou J, Yu T, Zhu X, Zou X, Peng Y, Xu Y, Yang Z, Chen G. Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain. Mol Neurodegener. 2015;10:33.
8. Yang LC, Li J, Lei H, Liu DM, Zhang M, Rong XF, Wang L, Peng Y*, Wang XL*. L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity After Focal Cerebral Ischemia in Rats. CNS Neurosci Ther. 2015;21(9):733-41.
9. Sun Y, Rong X, Lu W, Peng Y, Li J, Xu S, Wang L, Wang X. Translational Study of Alzheimer's Disease (AD) Biomarkers from Brain Tissues in AβPP/PS1 Mice and Serum of AD Patients. J Alzheimers Dis. 2015;45(1):269-82.
10. Peng Y, Hu Y, Xu S, Rong X, Li J, Li P, Wang L, Yang J, Wang X. Potassium 2-(1-hydroxypentyl)-benzoate improves memory deficits and attenuates amyloid and tau pathologies in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther. 2014;350(2):361-74.
11. Yang L, Wang ZH, Lei H, Chen RD, Wang XL, Peng Y*, Dai JG*. Neuroprotective glucosides of magnolol and honokiol from microbial-specific glycosylation. Tetrahedron. 2014;70(44):8244-8251.
12. Lei H, Zhao CY, Liu DM, Zhang Y, Li L, Wang XL*, Peng Y*. l-3-n-Butylphthalide attenuates β-amyloid-induced toxicity in neuroblastoma SH-SY5Y cells through regulating mitochondrion-mediated apoptosis and MAPK signaling. J Asian Nat Prod Res. 2014;16(8):854-64.
13. Jiang ZB, Jiang BY, Zhu CG, Guo QL, Peng Y, Wang XL, Lin S, Shi JG*. Aromatic acid derivatives from the lateral roots of Aconitum carmichaelii. J Asian Nat Prod Res. 2014;16(9):891-900.
14. Li CJ, Yang JZ, Yu SS, Zhao CY, Peng Y, Wang XL, Zhang DM. Glomexanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour. Fitoterapia. 2014;93:175-81.
15. Lu L, Wang W, Peng Y, Li J, Wang L, Wang X. Electrophysiology and pharmacology of tandem domain potassium channel TREK-1 related BDNF synthesis in rat astrocytes. Naunyn Schmiedebergs Arch Pharmacol. 2014:387(4):303-12.
16. Zhao W, Xu S, Peng Y, Ji X, Cao D, Li J, Liu B, Shi Q, Wang L, Wang X. Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats. Neurosci Lett. 2013;541:155-60.
17. Wang W, Zhang M, Li P, Yuan H, Feng N, Peng Y, Wang L, Wang X. An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. J Cardiovasc Pharmacol. 2013;61(4):302-10.
18. Hu Y, Peng Y, Long Y, Xu S, Feng N, Wang L, Wang X. Potassium 2-(1-hydroxypentyl)-benzoate attenuated hydrogen peroxide-induced apoptosis in neuroblastoma SK-N-SH cells. Eur J Pharmacol. 2012;680(1-3):49-54.
19. Peng Y, Hu YL, Xu SF, Li PP, Li J, Lu L, Yang HY, Feng N, Wang L, Wang XL. L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AßPP/PS1-Alzheimer transgenic mice. J Alzheimers Dis. 2012; 29(2):379-91.