李平平

李平平 博士、教授，协和。1978年出生于吉林省，2006年毕业于中国医学科学院药物研究所药理学专业获得博士学位。现为中国医学科学院&北京协和医学院药物研究所研究员、博士生导师，目前研究团队成员共计6人，其中具有分子遗传学、细胞生物学、实验动物学研究背景的助理研究员5人，研究实习员1人。2015年获得协和称号，2016年获得国家优秀青年科学基金。邮箱：lipp@imm.ac.cn

主要业绩
致力于研究肥胖、胰岛素抵抗及糖尿病发生的分子免疫学机制十余年。累计发表学术论文32篇，其中国际核心期刊论文29篇，申请4项发明专利。主要研究工作成果（通讯作者或第一作者）发表在Cell（2篇）、Nature? Medicine、Cell Metabolism、PNAS和Diabetes等杂志并受到相关研究人员广泛关注。

研究方向
目前课题组隶属于“天然药物活性物质与功能”国家重点实验室，主要研究领域包括内分泌学和内分泌药理学、免疫生物学和免疫药理、分子细胞生物学和药理学、信号传导通道调节机制等。

发表论文（2008-）
1. Li P*, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. (* co-corresponding author) PMID: **
2. Li, P. *, Spann, N.*, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C., Olefsky, J. NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids. Cell 2013; 155, 200-214. (* co-first author) PMID: **
3. Baeza-Raja B, Li PP*, D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony , Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K: p75 Neurotrophin Receptor Promotes Obesity and the Metabolic Syndrome. Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (* co-first author) PMID: **
4. Li PP, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM: Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 2011;147:815-826. PMID: **
5. Lee YS, Li PP*, Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB: Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483. (* co-first author). PMID: **
6. Li PP, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem 2010;285:15333-15345. PMID: **
7. Lu M, Li PP*, Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM: Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol 2010;24:1413-1422. (* co-first author). PMID: **
8. Patsouris D, Li PP*, Thapar D, Chapman J, Olefsky JM, Neels JG: Ablation of CD11c- positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008;8:301-309. (* co-first author). PMID: **
9. Li PP, Shan S, Chen YT, Ning ZQ, Sun SJ, Liu Q, Lu XP, Xie MZ, Shen ZF: The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol 2006;148:610-618. PMID: **
10. Baeza-Raja, B., Sachs, B. D., Li, P., Christian, F., Vagena, E., Davalos, D., Le Moan, N., Ryu, J. K., Sikorski, S. L., Chan, J. P., Scadeng, M., Taylor, S. S., Houslay, M. D., Baillie, G. S., Saltiel, A. R., Olefsky, J. M., and Akassoglou, K. (2016) p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell reports 14, 255-268. PMID: **
11. Bernardo, B., Lu, M., Bandyopadhyay, G., Li, P., Zhou, Y., Huang, J., Levin, N., Tomas, E. M., Calle, R. A., Erion, D. M., Rolph, T. P., Brenner, M., and Talukdar, S. (2015) FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance. Scientific reports 5, 11382. PMID: **
12. Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh da, Y., Izquierdo, C. L., Chung, H., Li, P., Traves, P. G., Bandyopadhyay, G., Pessentheiner, A. R., Ofrecio, J. M., Cook, J. R., Qiang, L., Accili, D., and Olefsky, J. M. (2015) Adipocyte SIRT1 knockout promotes PPARgamma activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular metabolism 4, 378-391. PMID: **
13. Lu, M., Li, P., Bandyopadhyay, G., Lagakos, W., Dewolf, W. E., Jr., Alford, T., Chicarelli, M. J., Williams, L., Anderson, D. A., Baer, B. R., McVean, M., Conn, M., Veniant, M. M., and Coward, P. (2014) Characterization of a novel glucokinase activator in rat and mouse models. PloS one 9, e88431. PMID: **
14. Lu, M., Sarruf, D.A., Li, P., Osborn, O., Sanchez-Alavez, M., Talukdar, S., Chen, A., Bandyopadhyay, G., Xu, J., Morinaga, H., et al. (2013). Neuronal sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry 288, 10722-10735. PMID: **
15. Reilly, S. M., Chiang, S. H., Decker, S. J., Chang, L., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J., White, N. M., Hochberg, I., Downes, M., Yu, R. T., Liddle, C., Evans, R. M., Oh, D., Li, P., Olefsky, J. M., and Saltiel, A. R. (2013) Nat Med 19, 313-321. PMID: **
16. Jonker, J.W., Suh, J.M., Atkins, A.R., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.Q., Phillips, C.T., et al. (2012). A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485, 391-394. PMID: **
17. Osborn, O., Oh, D.Y., McNelis, J., Sanchez-Alavez, M., Talukdar, S., Lu, M., Li, P., Thiede, L., Morinaga, H., Kim, J.J., et al. (2012). G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest 122, 2444-2453. PMID: **
18. Talukdar, S., Oh da, Y., Bandyopadhyay, G., Li, D., Xu, J., McNelis, J., Lu, M., Li, P., Yan, Q., Zhu, Y., et al. (2012). Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 18, 1407-1412. PMID: **
19. Xu, J., Morinaga, H., Oh, D., Li, P., Chen, A., Talukdar, S., Lazarowski, E., Olefsky, J.M., and Kim, J.J. (2012). GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J Immunol 189, 1992-1999. PMID: **
20. Nguyen, M. T., Chen, A., Lu, W. J., Fan, W., Li, P. P., Oh, D. Y., and Patsouris, D. (2012) Regulation of chemokine and chemokine receptor expression by PPARgamma in adipocytes and macrophages. PloS one 7, e34976 . PMID: **
21. He, B. K., Ning, Z. Q., Li, Z. B., Shan, S., Pan, D. S., Ko, B. C., Li, P. P., Shen, Z. F., Dou, G. F., Zhang, B. L., Lu, X. P., and Gao, Y. (2012) PPAR research 2012, 546-548. PMID: **
22. 环奕;刘泉;孙素娟;王振基; 李平平; 陈跃腾;申竹芳. rExendin-4 在 3 种糖尿病动物模型的体内药效学研究. 中国临床药理学杂志, 2012.28.285-288
23. Lu M, Sarruf DA, Talukdar S, Sharma S, Li PP, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM: Brain PPAR-gamma promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med 2011;17:618-622. PMID: **
24. Lu M, Patsouris D, Li PP, Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM: A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2010;298:E1036-1048. PMID: **
25. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li PP, Lu WJ, Watkins SM, Olefsky JM: GPR120 is an omega-3 fatty acid receptor mediating potent anti- inflammatory and insulin-sensitizing effects. Cell 2010;142:687-698. PMID: **
26.环奕;刘泉;孙素娟;王振基; 李平平; 陈跃腾;申竹芳. 新型胰岛素促分泌剂rExendin-4 体内药效学评价. 中国临床药理学杂志, 2010.830-834
27. Kim JJ, Li PP, Huntley J, Chang JP, Arden KC, Olefsky JM: FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes 2009;58:1275-1282. PMID: **
28. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li PP, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM: Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab 2009;297:E1137-1146. PMID: **
29. Yeh TY, Beiswenger KK, Li PP, Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW: Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase- deficient mice. Diabetes 2009;58:2476-2485. PMID: **
30. Patsouris D, Neels JG, Fan W, Li PP, Nguyen MT, Olefsky JM: Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem 2009;284:31223-31235. PMID: **
31. Nofsinger RR, Li PP, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM: SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A 2008;105:20021-20026. PMID: **
32. Wang ZJ, Liu Q, Li PP, Zou CH, Shen ZF: Effect of GCP-02, a PPARalpha/gamma dual activator, on glucose and lipid metabolism in insulin-resistant mice. Eur J Pharmacol 2008;580:277-283. PMID: **

课题组主要成员
侯少聪，博士，助理研究员
孔丽娟，博士，助理研究员
姜茜，博士，助理研究员
马春晓，博士，助理研究员
柳星峰，博士，助理研究员