王汝冰

王汝冰，河南许昌人，博士，副研究员，硕士研究生导师。

联系方式
Tel: ; E-mail: wangrubing@imm.ac.cn

教育背景
2009.09-2013.06 上海交通大学药学院 博士
2006.09-2009.06 中国药科大学药学院 硕士
2001.09-2005.06 海南师范大学化学系 本科
工作经历
2018.10-至今 中国医学科学院药物研究所 副研究员
2016.05-2018.09 中国医学科学院药物研究所 助理研究员
2015.09-2016.04 中国医学科学院药物研究所 科研助理
2013.08-2015.07 美国加州州立大学 博士后研究员
2006年至今一直从事药物化学领域研究工作，主要涉及活性天然产物的全合成、结构修饰、成药性研究及新合成方法学研究。目前累计发表研究论文近40篇，包括以第一或通讯作者发表在本领域主流期刊Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、Chemical Communiaction等研究论文20篇，申请发明专利12项，获得授权专利7项，其中1项国际专利分别获得美国和欧盟授权。先后获得国家自然基金青年项目、中国医学科学院医学与健康科技创新工程重大协同创新项目、十三五”重大新药创制等基金支持，并参加多项国家自然科学基金面上及重点项目。
专业研究领域
1. 活性天然产物的全合成与结构优化
2. 新药先导化合物的发现与优化
3. 新合成方法学的发现与应用研究
发表论文
1. Qingyun Fang, Haishan Jin, Rubing Wang*, Liming Zhao*. DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Chemical Communications. 2019, 55: 10587-10591
2. Jingru Zhang, Haishan Jin, Rubing Wang*, Liming Zhao*. Synthesis of 2,4-Diaryl-1,3 -benzoxazines via FeCl₃-Catalyzed annulation of ortho-hydroxyphenyl-substituted para- quinone methides with imidates. Advanced Synthesis & Catalysis. 2019, 361(20): 4811-4816.
3. Yanan Wang, Fei Liu, Yong Li, Shuanggang Ma, Jing Qu, Yunbao Liu, Chongshan Niu, Zhonghai Tang, Yuhuan Li, Rubing Wang*, Shishan Yu*. New glycosides from the twigs and leaves of Rhododendron latoucheae. J Asian Nat Prod Res. 2019, 21(4): 299-307.
4. Xiaojing Wang^#, Qi Zhang^#, Yuru Peng, Li Li; Jing Qu; Yunbao Liu, Song Xu, Shuanggang Ma, Yong Li, Zou Zhongmei, Rubing Wang*, Shishan Yu*. Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata. J. Asian Nat. Prod. Res., 2019, 21(3): 217-226.
5. Rubing Wang, Haining Lv, Shanshan Zhu, Xiaodong Ren, Song Xu, Shuanggang Ma, Yunbao Liu, Jing Qu*, Shishan Yu*. A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma. RSC Adv. 2018, 8: 29301-29308.
6. Shuanggang Ma^#, Rubing Wang^#, Wenrui Li, Yunbao Liu, Jing Qu, Yong Li, Song Xu, Xiaojing Wang, Shishan Yu*. New C-2 diastereomers of flavanone glycosides conjugated with 3-hydroxy-3- methylglutaric acid from the pericarp of Citrus grandis (L.) Osbeck. Bioorg. Chem. 2018, 80: 519-524.
7. Rubing Wang, Xiaojie Zhang, Chengsheng Chen, Guanglin Chen,Cristian Sarabia, Qiang Zhang, Shilong Zheng, Guangdi Wang, QiaoHong Chen*. Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models. Eur. J. Med. Chem. 2017, 133: 208-226.
8. Jiehuan Zhang^#, Rubing Wang^#, Defeng Li, Liming Zhao*. Green method to preparing oxindole-fused spirotetrahydrofuran scaffolds through methanesulfonic acid-catalyzed cyclization reactions of 3-allyl-3-hydroxy-2-oxindole in water. ACS Omega 2017, 2(10): 7022-7028.
9. 王汝冰，邓仕东，屈晶*，庾石山* 平滑苍耳果实化学成分研究，天然产物化学研究，2017, 29: 787-790.
10. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Synthesis and evaluation of 1,7- diheteroarylhepta-1,4,6-trien-2-ones as promising anticancer agents. Eur. J. Med. Chem. 2016, 110: 164-180.
11. Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Changde Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiaohong Chen*. Structure-activity relationship and pharmacokinetic studies of 1,5-diheteroarylpenta-1,4-dien-3-ones: A class of curcumin-based anticancer agents. J. Med. Chem. 2015, 58(11): 4713-4726.
12. Xu Zhang^#, Rubing Wang^#, Wen Zhou*, Sui Xiao, Qingqing Meng, Shaoshun Li*. Antitumor activity of DMAKO-05, a novel shikonin derivative, and its metabolism in rat liver microsome. AAPS PharmSciTech 2015, 16(2): 259-266.
13. Rubing Wang^#, Wen Zhou^#*, Qingqing Meng, Xu Zhang, Jing Ding, Yan Xu, Hualong Song, Kai Yang, Jiahua Cui, Shaoshun Li*. Design, synthesis and biological evaluation of shikonin and alkannin derivatives as potential antitumor agents via a prodrug approach. ChemMedChem 2014, 9(12): 2798-2808.
14. Rubing Wang^#, Xu Zhang^#, Hualong Song, Shanshan Zhou, Shaoshun Li*. Synthesis and evaluation of alkannin and shikonin oxime derivatives as potent antitumor agent. Bioorg. Med. Chem. Lett. 2014, 24(17): 4304-4307.
15. Hua-long Song, Shan-shan Zhou, Rubing Wang*, Shao-shun Li*. Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy. ChemMedChem 2013, 8(11): 1736-1749.
16. Rubing Wang, Runting Yin, Wen Zhou, Shaoshun Li*. Shikonin and its derivatives: a patent review. Expert Opin. Ther. Pat. 2012, 22(9): 977-997.
17. Rubing Wang, Hui Guo, Jiahua Cui, Shaoshun Li*. A novel and ef?cient total synthesis of shikonin. Tetrahedron Lett. 2012, 53(31): 3977-3980.
18. Rubing Wang, Shanshan Zhou, Hudagula Jiang, Xiaogang Zheng, Wen Zhou, Shaoshun Li*. An efficient multigram synthesis of alkannin and shikonin. Eur. J. Org. Chem. 2012, 2012(7): 1373-1379.
专利
1. 庾石山，陈晓光，王汝冰，吕海宁，徐嵩，季鸣，李燕，扈金平，马辰，张婷婷，马双刚，刘云宝(13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶A型，中国发明专利，申请号 0.5
2. 庾石山，陈晓光，王汝冰，吕海宁，徐嵩，季鸣，李燕，扈金平，马辰，张婷婷，马双刚，刘云宝(13aS)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的晶B型，2018.02.05，中国发明专利，申请号 9.2
3. 庾石山，王汝冰，吕海宁，徐嵩，马双刚，刘云宝光学纯(S)-3-新戊酰氧基-6,7-二甲氧基-菲并吲哚里西啶的制备方法，中国发明专利，申请号 3.3
4. 刘玉玲 王洪亮 汪仁芸 夏学军 庾石山 陈晓光 李燕 王汝冰 季鸣 金晶 扈金萍 菲并吲哚里西定生物碱衍生物纳米自乳化组合物及其制备方法，申请号：0.7
5. 刘玉玲 王洪亮 汪仁芸 夏学军 李琳庾石山 陈晓光 李燕 扈金萍 高丽丽 王汝冰 菲并吲哚里西定生物碱衍生物固体脂质纳米粒组合物， 中国发明专利， 申请号：5.5