蒋太交蒋太交课题组

蒋太交，研究员/博士生导师，中国医学科学院生物医学大数据中心主任，国家“基金”、中科院“”及北京协和医学院“协和”获得者。
研究方向：计算生物学和系统医学研究
电子邮件：taijiao@ibms.pumc.edu.cn

个人简历
1990-1994 湖南师范大学
1994-1999 中国科学院上海生物化学研究所，获生物化学和分子生物学博士学位
2001-2002 耶鲁大学计算机科学系，获计算机科学硕士学位
1999-2002 在耶鲁大学生物学系Sidney Altman教授实验室从事人核糖核酸P的结构和功能研究
2003-2004 在麻省理工学院Amy Keating教授实验室进行计算结构生物学和系统生物学研究
2004-2015 中国科学院生物物理研究所研究员
2015至今 中国医学科学院基础医学研究所系统医学研究中心、苏州系统医学研究所研究员

研究方向
蒋太交研究员课题组主要从事计算生物学和系统医学方面的研究，研究方向主要包括如下三方面：
（1）发展蛋白质结构预测、基因共进化分析、生物医学数据挖掘以及生物分子网络模建等计算生物学新方法;
（2）结合高通量实验手段，探究包括传染病在内的复杂疾病的分子机理;
（3）运用系统生物学方法，寻找疾病关键分子标志物，为疾病分类、早期诊断和治疗提供线索。

代表性论文
1. YousongPeng^#, Xiaodan Li^#, Hongbo Zhou, Aiping Wu, Libo Dong, YeZhang, Rongbao Gao, Hong Bo, Lei Yang, Dayan Wang, Xian Lin, Meilin Jin*,Yuelong Shu* and Taijiao Jiang*.Continual Antigenic Diversification in China Leads to Global AntigenicComplexity of Avian Influenza H5N1 Viruses. Scientific Reports. 2017 Mar 6; 7:43566.
2. YuanqiangZou, Zhiqiang Wu, Lizong Deng, Aiping Wu, Fan Wu, Kenli Li, Taijiao Jiang* and Yousong Peng*.cooccurNet: an R package for co-occurrence network construction and analysis. Bioinformatics. 2017 Feb 8. doi: 10.1093/bioinformatics/btx062.
3. YousongPeng^#, Dayan Wang, Jianhong Wang, Kenli Li, Zhongyang Tan, YuelongShu, and Taijiao Jiang*. A universalcomputational model for predicting antigenic variants of influenza A virusbased on conserved antigenic structures. Scientific Reports. 2017 Feb 6; 7:42051.
4. ChunfengLi^#, Zining Wang^#, Yang Cao^#, Lulan Wang,Jingyun Jie, Zhigao Chen, Tao Deng, TaijiaoJiang*, Genhong Cheng* and F. Xiao-Feng Qin*. Screening for NovelSmall-Molecule Inhibitors Targeting the Assembly of Influenza Virus PolymeraseComplex by a Bimolecular Luminescence Complementation-Based Reporter System. JVirol. 2017 Feb 14; 91(5). pii: e02282-16.
5. Yousong Peng^#, Lei Yang^#, Honglei Li, Yuanqiang Zou, Lizong Deng, Aiping Wu,Xiangjun Du, Dayan Wang, Yuelong Shu* and Taijiao Jiang*. PREDAC-H3: auser-friendly platform for antigenic surveillance of human influenza a (H3N2)virus based on hemagglutinin sequences. Bioinformatics.2016 Aug 15; 32(16):2526-7.
6. Lulan Wang^#, Stephanie G. Valderramos^#, Aiping Wu, Songying Ouyang, Chunfeng Li,Patricia Brasil, Myrna Bonaldo, Thomas Coates, Karin Nielsen-Saines, TaijiaoJiang*, Saba Aliyari*, Genhong Cheng*. From Mosquitos to Humans: GeneticEvolution of Zika Virus. Cell Host& Microbe. 2016 May 11; 19(5):561-5.
7. Lulan Wang^#, Aiping Wu^#, Yao E. Wang^#, Natalie Quanquin, Chunfeng Li, Jingfeng Wang,Hsiang-Wen Chen, Suyang Liu, Ping Liu, Hong Zhang, F. Xiao-Feng Qin, TaijiaoJiang*, Genhong Cheng*. Functional Genomics Reveals Linkers Critical forInfluenza Polymerase. J Virol.2016 March; 90(6):2938-47.
8. Mi Liu^#, Xiang Zhao^#, Sha Hua^#, Xiangjun Du, Yousong Peng, Xiyan Li, Yu Lan, DayanWang, Aiping Wu*, Yuelong Shu*, Taijiao Jiang*. Antigenic Patterns andEvolution of the Human Influenza A (H1N1) Virus. Scientific Reports. 2015 Sep 28; 5:14171.
9. Lizong Deng, Mi Liu, Sha Hua, Yousong Peng,Aiping Wu, F Xiao-Feng Qin*, Genhong Cheng* and Taijiao Jiang*. Networkof co-mutations in Ebola virus genome predicts the disease lethality. CellResearch. 2015 Jun; 25(6):753-6.
10. Chunfeng Li, Aiping Wu, Yousong Peng, JingfengWang, Yang Guo, Zhigao Chen, Hong Zhang, Yongqiang Wang, Jiuhong Dong, LulanWang, F. Xiao-Feng Qin, Genhong Cheng*, Tao Deng* &Taijiao Jiang*.Integrating computational modeling and functional assays to decipher thestructure-function relationship of influenza virus PB1 protein. ScientificReports. 2014 Nov 26; 4:7192.
11. Lizong Deng, Aiping Wu, Wentao Dai, Tingrui Song,Ya Cui, and Taijiao Jiang*. Exploring protein domain organization byrecognition of secondary structure packing interfaces. Bioinformatics.2014 Sep 1; 30(17):2440-6.
12. Aiping Wu, Chunhu Su, Dayan Wang, Yousong Peng, MiLiu, Sha Hua, Tianxian Li, George F. Gao, Hong Tang, Jianzhu Chen, Xiufan Liu,Yuelong Shu, Daxin Peng*, and Taijiao Jiang*. Sequential ReassortmentsUnderlie Diverse Influenza H7N9 Genotypes in China. Cell Host &Microbe. 2013 Oct 16; 14(4):446-52.
13. Chunfeng Li, Qi Ba, Aiping Wu, Hong Zhang, TaoDeng*, Taijiao Jiang*. A peptide derived from the C-terminus of PB1inhibits influenza virus replication by interfering with viral polymeraseassembly. FEBS J. 2013 Feb; 280(4):1139-49.
14. Yongqiang Wang, Xinlei Zhang, Hong Zhang, Yi Lu,Haolong Huang, Xiaoxi Dong, Jinan Chen, Jiuhong Dong, Xiao Yang, Haiying Hang, TaijiaoJiang*. Coiled-coil networking shapes cell molecular machinery. MolBiol Cell. 2012 Oct 1; 23(19):3911-22.
15. Xiangjun Du, Libo Dong, Yu Lan, Yousong Peng,Aiping Wu, Ye Zhang, Weijuan Huang, Dayan Wang, Min Wang, Yuanji Guo, YuelongShu* & Taijiao Jiang*. Mapping of H3N2 influenza antigenic evolutionin China reveals a strategy for vaccine strain recommendation. NatureCommunications, 28 Feb 2012; 3:709.
16. Zhichao Miao, Yang Cao, Taijiao Jiang*.RASP: Rapid modeling of protein side-chain conformations. Bioinformatics.2011 Nov 15; 27(22):3117-22.
17. Liqing Tian, Aiping Wu, Yang Cao, Xiaoxi Dong, YunHu, Taijiao Jiang*. NCACO-score: An effective main-chain dependentscoring function for structure modeling. BMC Bioinformatics, 2011May 26; 12: 208.
18. Yang Cao, Lin Song, Zhichao Miao, Yun Hu, LiqingTian, Taijiao Jiang*. Improved side-chain modeling by couplingclash-detection guided iterative search with rotamer relaxation. Bioinformatics,2011 Jan 6; 27 (6):785-90.
19. Hong Zhang, Taijiao Jiang*. Syntheticcircuits, devices and modules. Protein Cell, 2010 Nov;1(11):974-8.
20. Aiping Wu, Yousong Peng, Xiangjun Du, Yuelong Shu, TaijiaoJiang*. Correlation of Influenza Virus Excess Mortality with AntigenicVariation: Application to Rapid Estimation of Influenza Mortality Burden. PLoSComput Biol, 2010 Aug 12; 6(8):e**.
21. Hong Zhang, Jinan Chen, Yongqiang Wang, Lin Peng,Xiaoxi Dong, Yi Lu, Amy E. Keating*, Taijiao Jiang*. A computationallyguided protein screen uncovers coiled-coil interactions involved in vesicular transport. J Mol Biol, 2009 Sep 11; 392(1):228-41.
22. Xiangjun Du, Zhuo Wang, Aiping Wu, Lin Song, YangCao, Haiying Hang, and Taijiao Jiang*. Networks of genomic co-occurrencecapture characteristics of human influenza A (H3N2) evolution.Genome Res,2008 Jan 1; 18(1):178-87.