王少辉

研究领域：畜禽细菌病的致病机理、抗感染免疫及防控技术研究
电话/传真：
电子邮件：shwang@shvri.ac.cn, shwang0827@126.com
更多信息：比如实验室主页等
简历（200-500字）：
王少辉，男，博士，副研究员，2006年7月毕业于河南农业大学牧医工程学院，获学士学位；2006年9月考入南京农业大学农业部动物细菌学重点实验室预防兽医学专业，2011年6月获得博士学位。2008年12月-2009年7月作为访问****赴德国柏林自由大学进行交流学习。2011年7月至今，在中国农业科学院上海兽医研究所工作，主要研究方向为禽致病性大肠杆菌病、沙门菌病等细菌病的病原学、毒力因子致病机理、病原菌与宿主互作、诊断技术及疫苗研发。主持国家自然科学基金1项、中央级公益性科研院所基本科研业务费专项3项，作为主要执行人参加省部级以上课题5项。在国内外期刊发表研究性论文50余篇，其中SCI论文30余篇（第一作者8篇）。获得国家发明专利2项。2014年获得中国农业科学院2014年度科技成果二等奖1项。2013年、2014年连续两年获得中国农业科学院上海兽医研究所“先进文明职工”荣誉称号。
获奖及荣誉：
1、获得“2014年度中国农业科学院科技成果二等奖”1项
2、获得2014年度中国农业科学院上海兽医研究所“先进文明职工”荣誉称号
3、获得2013年度中国农业科学院上海兽医研究所“先进文明职工”荣誉称号
承担科研项目情况：
主持课题
1、p53基因敲除小鼠对单增李斯特菌的易感性分析及其机制研究，国家自然科学基金。
2、Ⅲ型分泌系统2（T3SS2）在禽致病性大肠杆菌感染过程中的作用及其机制研究，中央级公益性科研院所基本科研业务费专项资金项目
3、禽致病性大肠杆菌Ⅵ型分泌系统（T6SS）致病机理研究，中央级公益性科研院所基本科研业务费专项资金项目。
4、单增李斯特菌黏附及侵袭相关因子的筛选、鉴定及其致病机理研究，中央级公益性科研院所基本科研业务费专项资金项目。
代表论著：（前三作者SCI论文）
1、Shaohui Wang, Chunling Niu, Zhenyu Shi, Yongjie Xia, Muhammad Yaqoob, Jianjun Dai, Chengping Lu. Effects of ibeA deletion on virulence and biofilm formation of an avian pathogenic Escherichia coli. Infection and Immunity. 2011,79(1):279-287.
2、Xiangkai Zhuge, Shaohui Wang（共同一作）, Hongjie Fan, Zihao Pan, Jianluan Ren, Li Yi, Qingmei Meng, Xuqiu Yang, Chengping Lu, Jianjun Dai. Characterization and Functional Analysis of AatB, a Novel Autotransporter Adhesin and Virulence Factor of Avian Pathogenic Escherichia coli. Infection and Immunity. 2013,81(7):2437-2447.
3、Shaohui Wang, Jianjun Dai, Qingmei Meng, Xiangan Han, Yue Han, Yichao Zhao, Denghui Yang, Chan Ding, Shengqing Yu. DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli. Frontiers in Microbiology. 2014, 5:588.
4、Shaohui Wang, Zhenyu Shi, Yongjie Xia, Huiqin Li, Yahui Kou, Yinli Bao, Jianjun Dai, Chengping Lu. IbeB is involved in the invasion and pathogenicity of avian pathogenic Escherichia coli. Veterinary Microbiology. 2012,159(3-4):411-419.
5、Shaohui Wang, Qingmei Meng, Jianjun Dai, Xiangan Han, Yue Han, Chan Ding, Haiwen Liu, Shengqing Yu. Development of an Allele-Specific PCR Assay for Simultaneous Sero-Typing of Avian Pathogenic Escherichia coli Predominant O1, O2, O18 and O78 Strains. PLoS One. 2014, 9(5):e96904.
6、Shaohui Wang, Yinli Bao, Qingmei Meng, Yongjie Xia, Yichao Zhao, Yang Wang, Fang Tang, Xiangkai ZhuGe, Shengqing Yu, Xiangan Han, Jianjun Dai, Chengping Lu. IbeR facilitates stress-resistance, invasion and pathogenicity of avian pathogenic Escherichia coli. PLoS One. 2015,10(3):e**.
7、Shaohui Wang, Yongjie Xia, Jianjun Dai, Zhenyu Shi, Yahui Kou, Huiqin Li, Yinli Bao and Chengping Lu. Novel roles for autotransporter adhesin AatA of avian pathogenic Escherichia coli: colonization during infection and cell aggregation. FEMS Immunology and Medical Microbiology.2011,63:328-338.
8、Shaohui Wang, Shuxiao Zhang, Zhe Liu, Pingping Liu, Zixue Shi, JianchaoWei, Donghua Shao, Beibei Li, Zhiyong Ma. Molecular Characterization of Enterohemorrhagic E. coli O157 Isolated from Animal Fecal and Food Samples in Eastern China. Scientific World Journal. 2014,2014:946394.
9、Jianjun Dai, Shaohui Wang, Doreen Guerlebeck, Claudia Laturnus, Sebastian Guenther, Zhenyu Shi, Chengping Lu and Christa Ewers. Suppression subtractive hybridization identifies an autotransporter adhesin gene of E. coli IMT5155 specifically associated with avian pathogenic Escherichia coli. BMC Microbiology 2010,10:236.
10、Chunling Niu, Shaohui Wang, Chengping Lu. Development and evaluation of a Dot blot assay for rapid determination of invasion-associated gene ibeA directly in fresh bacteria cultures of E. coli. Folia Microbiology. 2012,57(6):557-561.
11、Wanwan Hou, Shaohui Wang, Xiaolan Wang, Xiangan Han, Hongjie Fan, Shoulin Cao, Jiaping Yue, Quan Wang, Wei Jiang, Chan Ding, Shengqing Yu.Development of colloidal gold immunochromatographic strips for detection of Riemerella anatipestifer. PLoS One. 2015,10(3):e**.
12、Yang Wang, Li Yi, Shaohui Wang, Chengping Lu, Chan Ding. Selective capture of transcribed sequences in the functional gene analysis of microbial pathogens. Applied Microbiology and Biotechnology. 2014,98(24):9983-9992.
13、Yinli Bao, Zhipeng Zhai, Shaohui Wang, Jiale Ma, Wei Zhang, Chengping Lu. Chaperonin GroEL: A novel phylogenetically conserved protein with strong immunoreactivity of Avian Pathogenic Escherichia coli isolates from duck identified by immunoproteomics. Vaccine. 2013,31(28):2947-2953.
14、M. Yaqoob, Liping. Wang, Shaohui Wang, S. Hussain, J. Mamon, J. Kashif and Chengping Lu. Associations Between Anti-Microbial Resistance Phenotypes, Anti-Microbial Resistance Genotypes and Virulence Genes of Escherichia coli Isolates from Pakistan and China. Transboundary and Emerging Diseases. 2012; (25):1865-1882.
15、Yue Han, Xiangan Han, Shaohui Wang, Qingmei Meng, Yuxi Zhang, Chan Ding, Shengqing Yu. The waaL gene is involved in lipopolysaccharide synthesis and plays a role on the bacterial pathogenesis of avian pathogenic Escherichia coli. Veterinary Microbiology. 2014,172(3-4):486-491.
16、Xiaolan Wang, Chan Ding, Shaohui Wang, Xiangan Han, Shengqing Yu. Whole-genome Sequence Analysis and Genome-wide Virulence Gene Identification of Riemerella anatipestifer Strain Yb2. Applied and Environmental Microbiology. 2015 May 22.
17、Xiaolan Wang, Chan Ding, Shaohui Wang, Xiangan Han, Wanwan Hou, Jiaping Yue, Jiechi Zou, Shengqing Yu. The AS87_04050 gene is involved in bacterial lipopolysaccharide biosynthesis and pathogenicity of Riemerella anatipestifer. PLoS One. 2014 9(10):e109962.
18、Zhicheng Zhang, Wei Dai, Shaohui Wang, Dingzhen Dai. Epidemiology and genetic characteristics of pigeon circovirus (PiCV) in eastern China. Archives of Virology. 2015,160(1):199-206.