孙英杰
研究领域：抗病毒先天性免疫及应激反应
电话/传真：
电子邮件：sunyingjie@shvri.ac.cn
简历：
孙英杰，男，博士，副研究员。预防兽医学博士。2013年毕业于中国农业科学院上海兽医研究所，获农学博士学位。研究方向为抗病毒先天性免疫及应激反应，先后主持国家自然科学面上基金、十三五重点专项子课题、上海市青年科技英才扬帆计划等6项，在Journal of Virology (2)、FASEB Journal、Molecular Immunology、Developmental and comparative immunology和中国预防兽医学报等国内外学术刊物上发表第一/通讯作者文章16篇，署名文章90余篇。担任中国畜牧兽医学会兽医公共卫生分会第一届理事会理事，2017年入选中国农业科学院青年英才计划“科研英才培育工程”。
工作和学习
2017至今，中国农业科学院上海兽医研究所，副研究员
2013-2017，中国农业科学院上海兽医研究所，助理研究员
2010/09-2013/06中国农业科学院上海兽医研究所，预防兽医学，博士
2007/09-2010/06 中国农业科学院上海兽医研究所，预防兽医学，硕士
2003/09-2007/03 扬州大学，兽医学院，学士
承担科研项目：
1． 国家重点研发计划，畜禽重大疾病防控与高效安全养殖综合技术研发，58.5万元，在研，子课题；
2． 国家自然科学基金，新城疫病毒V蛋白靶向MAVS抑制先天性免疫机制研究，59万元，在研，主持。
3． 国家自然科学基金，应激颗粒对新城疫病毒复制与先天性免疫的调控机制研究，25万元、结题、主持。
4． 上海市青年科技英才杨帆计划、应激颗粒在新城疫病毒感染过程中的作用、10万元、结题、主持。
代表论著：
[1] Yingjie Sun?, Hang Zheng?, Shengqing Yu, Yunlei Ding, Wei Wu, Xuming Mao, Ying Liao, Chunchun Meng, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Fengyun Wu, and Chan Ding*. Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5 [J]. Journal of Virology, 2019. IF=4.3
[2] Yingjie Sun?, Xuming Mao?, Hang Zheng, Wei Wu, Zaib Ur Rehman, Ying Liao, Chunchun Meng, Xusheng Qiu, Lei Tan, Cuiping Song, Lei Xu, Shengqing Yu, and Chan Ding*. Goose MAVS functions in RIG-I-mediated IFN-β signaling activation [J]. Developmental and comparative immunology, 2019, 93: 58-65. IF=3.1
[3] Shanhui Ren, Zaib Ur Rehman, Mengyu Shi, Bin Yang, Yurong Qu, Xiao Feng Yang, Qi Shao, Chunchun Meng, Zengqi Yang, Xiaolong Gao, Yingjie Sun*, Chan Ding*. Syncytia generated by hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus induce complete autophagy by activating AMPK-mTORC1-ULK1 signalin [J]. Veterinary Microbiology, 2019, 230: 283–290. IF=2.8
[4] Shanhui Ren, Zaib Ur Rehman, Mengyu Shi, Bin Yang, Panrao Liu, Yuncong Yin, Yurong Qu, Chunchun Meng, Zengqi Yang, Xiaolong Gao, Yingjie Sun* and Chan Ding*. Hemagglutinin-neuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion–fssion homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress [J]. Veterinary Research, 2019, 50:37. IF=3.1
[5] Yingjie Sun, Pin Zhang, Hang Zheng, Luna Dong, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Chunchun Meng, Shengqing Yu, Chan Ding*. Chicken RNA-binding protein T-cell internal antigen-1 contributes to stress granule formation in chicken cells and tissues [J]. Journal of Veterinary Science, 2018, 19(1), 3-12. IF=1.5
[6] Yingjie Sun, Luna Dong, Shengqing Yu, Xiaoxu Wang, Hang Zheng, Pin Zhang, Chunchun Meng, Yuan Zhan, Lei Tan, Cuiping Song, Xusheng Qiu, Guijun Wang, Ying Liao, and Chan Ding*. Newcastle disease virus induces stable formation of bona fide stress granules to facilitate viral replication through manipulating host protein translation [J]. FASEB Journal, 2017, 31 (4). IF=5.4
[7] Xiangxiang Sheng, Yingjie Sun, Yuan Zhan, Yurong Qu, Huaxia Wang, Miao Luo, Ying Liao, Xusheng Qiu, Chan Ding, Hongjie Fan, Xiang Mao*. The LXR ligand GW3965 inhibits Newcastle disease virus infection by affecting cholesterol homeostasis [J]. Archives of virology. 2016, 161:2491–2501. IF=2.3
[8] Jinghua Cheng, Yingjie Sun, Fanqing Zhang, Xiaorong Zhang, Xvsheng Qiu, Liping Yu, Yantao Wu, Chan Ding*. Newcastle disease virus NP and P proteins induce autophagy via the endoplasmic reticulum stressrelated unfolded protein response [J]. Scientific Report. 2016, 6, 24721. IF=4.0
[9] Yuqiang Cheng, Yingjie Sun, Hengan Wang, Yaxian Yan, Chan Ding, Jianhe Sun. Chicken STING Mediates Activation of the IFN Gene Independently of the RIG-I Gene [J]. Journal of Immunology, 2015, 195(8): 3922-36. IF=4.7
[10] Yingjie Sun, Shengqing Yu, Na Ding, Chunchun Meng, Songshu Meng, Shilei Zhang, Yuan Zhan, Xusheng Qiu, Lei Tan, Hongjun Chen, Cuiping Song, Chan Ding*. Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues [J]. Journal of Virology, 2014, 88(1): 525-537. IF=4.3
[11] Jinghua Cheng, Yingjie Sun, Xiaorong Zhang, Fanqing Zhang, Shilei Zhang, Shengqing Yu, Xusheng Qiu, Lei Tan, Cuiping Song, Song Gao, Yantao Wu*, Chan Ding*. Toll-like receptor 3 inhibits Newcastle disease virus replication through activation of pro-inflammatory cytokines and the type-1 interferon pathway [J]. Archives of virology, 2014, 159(11): 2937-48. IF=2.3
[12] Yingjie Sun, Na Ding, Siyu Serena Ding, Shengqing Yu, Chunhun Meng, Hongjun Chen, Xusheng Qiu, Shilei Zhang, Yang Yu, Yuan Zhan, Chan Ding*. Goose RIG-I functions in innate immunity against Newcastle disease virus infections [J]. Molecular Immunology, 2013, 53(4): 321-327. IF=3.1
[13] Shilei Zhang?, Yingjie Sun?, Hongjun Chen, Yabin Dai, Yuan Zhan, Shengqing Yu, Xusheng Qiu, Lei Tan, Cuiping Song and Chan Ding*. Activation of the PKR/eIF2 alpha signaling cascade inhibits replication of Newcastle disease virus [J]. Virology Journal, 2014, 11. IF=2.5