姓名：李灏
职称：副教授
邮箱：lihao@mail.buct.edu.cn
办公地址： 科技大厦301

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教育背景：
1995-1999 山东大学 微生物学专业 理学学士
1999-2002 山东大学 微生物学专业 理学硕士
2002-2005 中国海洋大学 海洋生物学专业 理学博士

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工作经历：
2005-2008 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，博士后研究工作
2008至今 北京化工大学生命科学与技术学院

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主要研究领域：
1、生物乙醇发酵过程中乙醇胁迫问题（胁迫机制、如何提高乙醇耐受性）；
2、生物乙醇发酵过程中染菌问题（利用生物法防控杂菌污染、杂菌污染对酿酒酵母细胞代谢及社会行为学的影响）；
3、代谢组学及其应用；
4、核酸适配体筛选及其应用。

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代表性著作：
2017年文章：
Ye Duan, Lihui Wang, Zhiqiang Gao, Huishan Wang, Hexiao Zhang, Hao Li*. An aptamer-based effective method for highly sensitive detection of chloramphenicol residues in animal-sourced food using real-time fluorescent quantitative PCR. Talanta, 2017, 165: 671-676. (*通讯作者)
Bo Liu, Huaqing Liu, Yunxiao Zhang, Hao Li*. Control of Lactobacillus plantarum contamination in bioethanol fermentation by adding plantaricins. International Journal of Agricultural & Biology, 2017, 19: 171-176. (*通讯作者)
Juan Tian, Shuxian Zhang, Hao Li*. Changes in intracellular metabolisms underlying the adaptation of Saccharomyces cerevisiae strains to ethanol stress. Annals of Microbiology, 2017, 67 (2): 195-202. (*通讯作者)
2016年文章：
Ze Chen, Zhou Zheng, Chenfeng Yi, Fenglian Wang, Yuanpu Niu, Hao Li*. Intracellular metabolic changes of Saccharomyces cerevisiae and promotion to ethanol tolerance during the bioethanol fermentation process. RSC Advances, 2016, 6: 105046-105055. (*通讯作者)
Yuanpu Niu, Xianghua Lin, Shijun Dong, Qipeng Yuan, Hao Li*. Indentation with atomic force microscope, Saccharomyces cerevisiae cell gains elasticity under ethanol stress. International Journal of Biochemistry and Cell Biology, 2016, 79: 337-344. (*通讯作者)
Yanfeng Wang, Juan Tian, Zhihua Ji, Maoyong Song, Hao Li*. Intracellular metabolic changes of Clostridium acetobutylicum and promotion to butanol tolerance during biobutanol fermentation. International Journal of Biochemistry and Cell Biology, 2016, 78: 297-306. (*通讯作者)
Ye Duan, Zhiqiang Gao, Lihui Wang, Huishan Wang, Hexiao Zhang*, Hao Li*. Selection and identification of chloramphenicol specific DNA aptamers by Mag-SELEX. Applied Biochemistry and Biotechnology, 2016, 180 (8): 1644-1656. (*通讯作者)
Chenfeng Yi, Fenglian Wang, Shijun Dong, Hao Li*. Changes of trehalose content and expression of relative genes during the bioethanol fermentation by Saccharomyces cerevisiae. Canadian Journal of Microbiology, 2016, 62 (10): 827-835. (*通讯作者)
2015年文章:
Shijun Dong, Chenfeng Yi, Hao Li*. Changes of Saccharomyces cerevisiae cell membrane components and promotion to ethanol tolerance during the bioethanol fermentation. The International Journal of Biochemistry & Cell Biology, 2015, 69: 196-203. (*通讯作者)
Fengxia Cui, Huaqing Liu, Zhongmei Zou, Hao Li*. Metabolic responses to water deprivation in C57BL/6J mice using a proton nuclear magnetic resonance-based metabonomics approach. RSC Advances, 2015, 5, 80142-80149. DOI: 10.1039/C5RA12650A. (*通讯作者)
Fengxia Cui, Ruimin Zhang, Hua1ing Liu, Yanfeng Wang, Hao Li*. Metabolic responses to Lactobacillus plantarum contamination or bacteriophage treatment in Saccharomyces cerevisiae using a GC-MS-based metabolomics approach. World Journal of Microbiology & Biotechnology, 2015, 31(12): 2003-2013. (*通讯作者)
RiBang Wu, CuiLing Wu, Dan Liu, XingHao Yang, JiaFeng Huang, Jiang Zhang, Binqiang Liao, HaiLun He, Hao Li*. Overview of antioxidant peptides derived from marine resources: the sources, characteristic, purification, and evaluation methods. Applied Biochemistry and Biotechnology. 2015, 176 (7), 1815-1833. (*通讯作者)
Shijun Dong, Xianghua Lin, Hao Li*. Regulation of Lactobacillus plantarum contamination on the carbohydrate and energy related metabolisms of Saccharomyces cerevisiae during bioethanol fermentation. Int J Biochem Cell Biol. 2015 Aug 14; 68: 33-41. (*通讯作者)
Xianghua Lin, Pei Han, Shijun Dong, Hao Li*. Preparation and application of bacteriophage-loaded chitosan microspheres for controlling Lactobacillus plantarum contamination in bioethanol fermentation. RSC Advances, 2015, 5: 69886-69893. (*通讯作者)
Yanfeng Wang, Shuxian Zhang, Huaqing Liu, Lei Zhang, Chenfeng Yi, Hao Li*. Changes and roles of membrane compositions in the adaptation of Saccharomyces cerevisiae to ethanol. Journal of Basic Microbiology, 2015, 55 (12): 1417-1426. (*通讯作者)
Dan Liu, XingHao Yang, JiaFeng Huang, RiBang Wu, CuiLing Wu, HaiLun He, Hao Li*. In situ demonstration and characteristic analysis of the protease components from marine bacteria using substrate immersing zymography. Applied Biochemistry and Biotechnology, 2015, 175 (1): 489-501. Short title: Analysis of protease by immersing zymography. (*通讯作者)
段烨, 高志强, 王慧珊, 张鹤晓*, 李灏*. 核酸适体技术及其在兽药残留检测中的应用. 中国兽医杂志, 2015, 51 (11): 75-78. (*通讯作者)
2014年文章：
方华, 李灏*. 海藻糖与热激蛋白在酿酒酵母耐受乙醇胁迫中的作用, 中国生物工程杂志, 2014, 34（6）: 84-89. (*通讯作者)
2013年文章：
Manli Ma, Pei Han, Ruimin Zhang, Hao Li*. Ultrastructural changes of Saccharomyces cerevisiae in response to ethanol stress. Canadian Journal of Microbiology, 2013, 59 (9): 589-597.(*通讯作者)
Xianmei Hu, Hao Li*, Pingwah Tang, Jie Sun, Qipeng Yuan, Chunfang Li. GC-MS-based metabolomics study of the responses to arachidonic acid in Blakeslea trispora. Fungal Genetics and Biology, 2013, 57: 33-41. (*共同第一作者)
Hongxia Chen, Fengxia Cui, Hao Li, Jun Sheng, Jie Lv. Metabolic changes during the pu-erh tea pile-fermentation revealed by a liquid chromatography tandem mass-spectrometry-based metabolomics approach. Journal of Food Science, 2013, 78 (11): C1665-C1672.
刘华擎, 李灏*. 生物质能源发酵中染菌及防控的研究进展, 中国生物工程杂志, 2013, 33 （12）: 114-120. (*通讯作者)
2012年文章：
Hao Li, Manli Ma, Sha Luo, Ruimin Zhang, Pei Han, Wei Hu. Metabolic responses to ethanol in Saccharomyces cerevisiae using a gas chromatography tandem mass spectrometry-based metabolomics approach. The Intenational Journal of Biochemistry & Cell Biology, 2012, 44 (7): 1087-1096.
Hao Li, Manli Ma, Huijun Xie, Jian Kong. Biosafety evaluation of bacteriophages for treatment of diarrhea due to intestinal pathogen Escherichia coli 3-2 infection of chickens. World Journal of Microbiology and Biotechnology, 2012, 28 (1): 1-6.
Jie Sun, Hao Li, Qipeng Yuan. Metabolic regulation of trisporic acid on Blakeslea trispora revealed by a GC-MS-based metabolomic approach. PLoS One, 2012, 7 (9): e46110.
2011年文章：
Hao Li, Lan Wang, Xianzhong Yan, Qijun Liu, Chaohui Yu, Handong Wei, Youming Li, Xuemin Zhang, Fuchu He, Ying Jiang. A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. Journal of Proteome Research, 2011, 10 (6): 2797-2806.
2011年之前的文章：
Hao Li, Ying Jiang, Fu-Chu He. Bioscience Hypotheses, 2009, 2, 27-30.
Hao Li, Jinlai Miao, Fengxia Cui, Guangyou Li. Marine Biotechnology, 2008,10,527-537.
Hao Li, Jinlai Miao, Fengxia Cui, Guangyou Li. Journal of Phycology, 2008, 44, 1364-1371.
Hao Li, Jinlai Miao, Fengxia Cui, Guangyou Li. Journal of Environmental Sciences, 2006, 18, 1152-1156.
Hao Li, Jinlai Miao, Fengxia Cui, Xiaoguang Liu, Guangyou Li. Journal of Environmental Sciences, 2005, 17, 499-502.
Hao Li, Jinlai Miao, Fengxia Cui, Guangyou Li. Journal of Ocean University of China, 2007, 6, 365-368.
李灏, 姜颖, 贺福初. 遗传, 2008, 30, 1-11.
李灏, 姜颖, 贺福初. 中国药理学与毒理学杂志, 2008, 22, 396-400.
李灏, 姜颖, 贺福初. 中国生物化学与分子生物学报, 2007, 23, 817-822.
李灏, 缪锦来, 刘晓光, 崔凤霞, 李光友. 海洋学报, 2006, 28, 127-132.
李灏, 缪锦来, 游银伟, 崔凤霞, 李光友. 海洋环境科学, 2008, 27, 13-16.
李灏, 缪锦来, 李光友. 海洋环境科学, 2006, 25, 1-3.
李灏, 谢慧君, 孔健, 马桂荣. 微生物学通报, 2004, 31, 10-13.
李灏, 缪锦来, 崔凤霞,李光友. 中国水产科学, 2004, 11, 456-461.

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招生要求：
动手能力强，思维活跃，视野开阔