北京航空航天大学导师教师信息介绍简介-张永彪

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个人简介
北京航空航天大学大数据精准医疗高精尖创新中心任特聘副研究员，博士生导师。主要从事生物信息学、多组学研究，以神经嵴细胞、动脉粥样硬化、常见病、罕见病为对象，运用单细胞测序、二代测序、细胞生物学、CRISPR-Cas9基因编辑技术揭示疾病发病机制和胚胎发育过程。主持3项国家自然科学基金面上项目和1项青年项目，累计主持研究经费400余万，参与国自然和北京市教委重点项目等6项。以第一作者或通讯作者身份发表SCI论文10篇，累计影响因子51分，其中代表论文发表在《Nature Communications》、《Human Molecular Genetics》等杂志，还参与发表SCI论文15篇。单篇论文影响子最高12分，单篇论文最高引用110次。为《Journal of Medical Genetics》、《Journal of Dental Research》、“Research Grants Council（HongKong）”等期刊和基金评委。

教育经历
1999.9-2003.6
云南大学 | 遗传学 | Bachelor's Degree | 大学本科毕业

2003.8-2008.7
中国医学科学院中国协和医科大学 | 人类遗传学 | 博士学位 | 博士研究生毕业

工作经历
2008.7-2018.3
中国科学院北京基因组研究所|重点实验室

研究方向
动脉粥样硬化
神经嵴细胞发育
多组学
单细胞测序
生物信息学

基本信息
姓名：张永彪
学位：博士学位
职称：副研究员
单位：北京航空航天大学大数据精准医疗高精尖创新中心
个人简介
北京航空航天大学大数据精准医疗高精尖创新中心任特聘副研究员，博士生导师。主要从事生物信息学、多组学研究，以神经嵴细胞、动脉粥样硬化、常见病、罕见病为对象，运用单细胞测序、二代测序、细胞生物学、CRISPR-Cas9基因编辑技术揭示疾病发病机制和胚胎发育过程。主持3项国家自然科学基金面上项目和1项青年项目，累计主持研究经费400余万，参与国自然和北京市教委重点项目等6项。以第一作者或通讯作者身份发表SCI论文10篇，累计影响因子51分，其中代表论文发表在《Nature Communications》、《Human Molecular Genetics》等杂志，还参与发表SCI论文15篇。单篇论文影响子最高12分，单篇论文最高引用110次。为《Journal of Medical Genetics》、《Journal of Dental Research》、“Research Grants Council（HongKong）”等期刊和基金评委。
论文
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[1] The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts nature metabolism, 2019,
[2] Identification of the CFTR c.1666A>G Mutation in Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis， Front. Neurosci, 2018,
[3] Discovery of Susceptibility Loci Associated with Tuberculosis in Han Chinese， Human Molecular Genetics, 2017,
[4] Genome-wide Association Study Identifies Multiple Susceptibility Loci For Craniofacial Microsomia， Nature Communications, 2016,
[5] Association of ARNTL and PER1 genes with Parkinson’s disease: a case-control study of Han Chinese. Scientific Reports, 2015,
[6] 5.F Chen#*, Q Li#, M Gu, X Li, J Yu, Yong-Biao Zhang*, Identification of a Mutation in FGF23 Involved in Mandibular Prognathism, Scientific Reports, 2015 Jun 10;5:11250. doi: 10.1038/srep11250
[7] 6.L-Y Sun#, Yong-Biao Zhang#, L Jiang, N Wan, W-F Wu, X-D Pan, J Yu, F Zhang*, L Wang*, Identification of the gene defect responsible for severe hypercholesterolaemia using whole-exome sequencing, Scientific Reports, 2015 Jun 16;5:11380. doi: 10.1038/srep11380
[8] 7.X Li#, J Hu#, J Zhang, Q Jin, D-M Wang, J Yu, Q Zhang*, Yong-Biao Zhang*, Genome-Wide Linkage Study Suggests a Susceptibility Locus for Isolated Bilateral Microtia on 4p15.32–4p16.2, PLoS One, 2014, 9(7)
[9] 8.Yong-Biao Zhang#, X Li#, F Zhang*,D-M Wang, J Yu. A preliminary study of copy number variation in Tibetans. PLoS One, 7(7):e41768, 2012
[10] 9.B Wang#, Yong-Biao Zhang#, F Zhang, H Lin, X Wang, N Wan, Z Ye, H Weng, L Zhang, X Li, J Yan, P Wang, T Wu, L Cheng, J Wang, D-M Wang*, X Ma*, Jun Yu. On the Origin of Tibetans and their Genetic Basis in Adapting High-Altitude Environments. PLoS One, 6(2): e17002, 2011
[11] 10.Yong-Biao Zhang#, F Zhang, H Lin, L Shi, P Wang, Q Gong, X Li, M Wang, S Hu, J Chu*, D-M Wang*. Nucleotide polymorphism of the TNF gene cluster in six Chinese populations. J Hum Genet 55: 350-357, 2010
[12] 11.张永彪,褚嘉佑. 表现遗传学与人类基因组,科学（上海），10.3969/j.issn.0368-6396.2007.03.010
[13] 12.张永彪,褚嘉佑. 表观遗传学与人类疾病的研究进展. 遗传, 27(3):466-472, 2005
[14] 13.Qing Lin Peng#, JinMing Lin#, YongBiao Zhang, XueZhi Zhang, PanPan Wang, TingTing Wu, Jun Yu, XiaoQun Dong, MingLiang Gu*, GuoChun Wang*, Targeted capture sequencing identifies novel genetic variations in Chinese patients with idiopathic inflammatory myopathies. International Journal of Rheumatic Diseases, 2018, 27(8):1619-1626.
[15] 14.Cheng L, Hu JT, Zhou X, Li ZB, Zhang Yong-Biao, Cao YL, Zhang QG*, Liu T*. The Retrograde Transposition of the Remnant Earlobe in Patients With Low-Set Microtia. J Craniofac Surg. 2015, 26(7):2177-9,wos:**032
[16] 15.Hu Jintian#, LiuTun, Zhou Xu, Zhang Yong-Biao, Zhang Qingguo*, Unlilateral microtia, dextrocardia and situs inversus totalis: A possible new association., Journal of Plastic Reconstructive and Aesthetic Surgery, 2015, 68(2): 35-36,wos: **003
[17] 16.Hu Jin-Tian#, Liu Tun, Qian Jin, Zhang Yong-Biao, Zhou Xu, Zhang Qing-Guo, Occurrence of different external ear deformities in monozygotic twins: report of 2 cases., Plast Reconstr Surg Glob Open, 2014, 2(9): e206-e206
[18] 17.Hu J#, Zhang Q, Zhang Yong-Biao, Zhou X, Qian J, Liu T*, Partial helix defect repair by use of flap combined with ipsilateral conchal cartilage graft., Journal of Plastic Reconstructive and Aesthetic Surgery, 2014, 67(8): 1045-1049,wos: **013
[19] 18.Hu Jintian#, Liu Tun, Zhou Xu, Zhang Yong-Biao, Zhang Qingguo, Treatment of postburn ear defect with expanded upper arm flap and consequent expansion without skin grafting, Annals of Plastic Surgery, 2014, 72(4): 398-401,wos: **007
[20] 19.Liu M#, Pan H, Zhang F, Zhang Yongbiao, Zhang YX, Zhu J, Fu W*, Zhang X*, Identification of TNM stage-specific genes in lung adenocarcinoma by genome-wide expression profiling, ONCOLOGY LETTERS, 2013, 6(3): 763-768,wos: **026
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