脑脊液中t-tau蛋白的全基因组网络辅助分析和富集研究

删除或更新信息，请邮件至freekaoyan#163.com(#换成@)

本站小编 Free考研考试/2021-12-21

二维码（扫一下试试看！）

脑脊液中t-tau蛋白的全基因组网络辅助分析和富集研究

Genome-Wide Network-Assisted Association and Enrichment Study on CSF t-tau

投稿时间：2018-10-20

DOI：10.15918/j.tbit1001-0645.2019.s1.002

中文关键词:阿尔兹海默症脑脊液 t-tau蛋白网络分析通路分富集分析

English Keywords:Alzheimers disease cerebrospinal fluid total tau network analysis pathway analysis

基金项目:国家自然科学基金资助项目（61773134、61803117）；中央高校基本科研业务费专项资金资助项目（HEUCFG201824）；国家重大科学仪器设备可开发专项基金资助项目（2012YQ04014010）

摘要点击次数:4009

全文下载次数:344

中文摘要:

一些基因变异已被发现与阿尔茨海默病典型表型脑脊液相关，但这些发现忽略了小效应风险的变体、基因座内部关联以及与外部环境之间的相互关系.为此，作者利用基于功能网络和基于通路信息的方法从系统生物学角度对遗传变异进行识别.将反映阿尔茨海默症早期病理特点的CSF t-tau作为表型，在全基因组关联分析的基础上提出一种基于权重调整的PageRank网络功能模块挖掘策略.该策略不仅挖掘到广泛研究的与t-tau相关的遗传变异，挖掘到的子网也富集在如神经退行性疾病，神经系统和信号转导等通路中，表明在系统生物学层面，策略识别的特征优先子网与表型具有一定的功能关联.

English Summary:

Some genetic variants have been discovered to associated with cerebrospinal fluid (CSF) in Alzheimer's disease, yet it does not adapt with the small effect risk variants and ignores the inter-relationship among loci and outer-relationship with environment. As an alternative strategy, functional network-based and pathway-based information could be involved in high-level variants identify process, from system biology view. On the basis of genome-wide association analysis, a weighted-adjusted PageRank network function module mining strategy was proposed to analysis CSF t-tau, which was arranged as a measure reflecting the early pathological characteristics of Alzheimer's disease. The strategy can not only excavate widely studied t-tau-related genetic variations, but also can excavate subnetworks enriched in pathways, such as neurodegenerative diseases, nervous system and signal transduction. It indicates that, subnetworks identified by the strategy have a certain functional relationship with t-tau at the system biology level.

查看全文查看/发表评论下载PDF阅读器

閻庢鍠掗崑鎾绘⒑椤愶絿鎽孖P闂佹寧绋掗惌顔剧博閸撗呯煋鐎广儱鐗冮崑鎾诲礃椤忓棗鐓涢梺鍏兼緲閸熸娊鎯佹径灞惧枂闁糕剝渚楅弳銉╂⒒閸涱厾绠ｇ紒灞界埣閹洨鈧絽澧庣粈澶嬫叏閿濆懐绠叉繝鈧悧鍫⑩枖鐎广儱鎳庨悡鍌氣槈閹绢垰浜鹃梺鍛婂笒濡繈骞愰敓锟�
547闂佸湱顣介崑鎾绘⒒閸曗晛鐏柣妤€閰ｉ幊鎾诲礃椤忓棗鐓涢梺鍏兼緲閸燁偄鐣烽敓锟�1130缂備礁顦粔鐢碘偓鍨皑閳ь剝顫夌喊宥夊汲閳ь剟鏌℃径瀣婵炲牊鍨垮畷锟犲礃瑜忕粙鍥╃磼婢跺﹦效闁告ǜ鍊栫缓钘壩旈崪浣规瘜闁圭厧鐡ㄩ幐鍫曞焵椤戞寧绁版い顐㈩儐閿涙劙骞嬮婊咁槷濠电偞鍨归弫绋棵烘繝鍥ㄥ殣閺夊牜鍋掗崵鏃堟煏閸℃洝鍏岀紒顔光偓瓒佽鎯斿☉鎺戜壕濞达絿鏅Σ鍫ユ煕閹烘挻鍋犻柍褜鍏涚欢姘跺闯妤ｅ啯鎳氱€广儱鍟犻崑鎾存媴閻戞ê鈧偟鈧鎮堕崕顖炲焵椤戣儻鍏屾い鎾存倐閹爼宕遍幇銊ヤ壕濞达絾浜芥禒锕€霉閸忕厧鎼搁柍褜鍏涘ù鍥磼閵婏箑顕辨慨妯稿劗閸嬫挻鎷呯憴鍕暚闂佺厧寮惰ぐ鍐紦妤ｅ啯鍋犻柛鈩冨姀閸嬫挻鎷呴悿顖氬箑闂佸搫鍊稿ú銏ゅ焵椤戞寧绁板瑙勬崌瀵敻顢涘Ο宄颁壕濞达綀顫夐悡鈧梻鍌氬€介濠勬閸洖绠绘い鎾村閸嬫挻鎷呴崷顓溾偓濠囨倵濞戝疇绀嬮柍褜鍏涚粈浣轰焊閹殿喒鍋撳☉瀹犵闁逞屽厸濞村洭顢橀崫銉т笉婵°倓鐒︾花姘舵煏閸℃洜顦︾€圭ǹ顭峰畷锝囦沪閸屾浜惧ù锝呮啞閸曢箖鏌ｉ悙鍙夘棑闁逞屽厸閻掞箓寮崒姘ｆ煢婵懓娲犻崑鎾存媴閸涘﹥鍣搁柣搴㈠喕鐠愮喖鍩€椤戞寧顦风紓宥咁儔閹虫牠鎳犻鍐炬蕉缂備焦鍐婚幏锟�28缂備緡鍋夐褔顢楅悢铏圭煋闁规惌鍨崇粈濉欼P婵炴潙鍚嬮懝楣冨箟閾忣偅濯撮幖娣€曞▓锟�128.00闂佺ǹ绻愰崰娑氭閿燂拷