Circular RNAs (circRNAs) from back-splicing of exon(s) have been recently identified to be broadly expressed in eukaryotes, in tissue- and species-specific manners. Although functions of most circRNAs remain elusive, some circRNAs are shown to be functional in gene expression regulation and potentially relate to diseases. Due to their stability, circRNAs can also be used as biomarkers for diagnosis. Profiling circRNAs by integrating their expression among different samples thus provides molecular basis for further functional study of circRNAs and their potential application in clinic. Here, we report CIRCpedia v2, an updated database for comprehensive circRNA annotation from over 180 RNA-seq datasets across six different species. This atlas allows users to search, browse, and download circRNAs with expression features in various cell types/tissues, including disease samples. In addition, the updated database incorporates conservation analysis of circRNAs between humans and mice. Finally, the web interface also contains computational tools to compare circRNA expression among samples. CIRCpedia v2 is accessible at http://www.picb.ac.cn/rnomics/circpedia.
外显子反向剪接产生的环形RNA是一类不具有5'末端帽子和3'末端poly(A)尾巴、却以共价键形成闭环结构的RNA新分子，其在真核生物中广泛表达、并具有显著的组织和物种特异表达方式。因此，绘制环形RNA的组织和物种表达谱将为深入研究其详细的生成加工机制和潜在功能作用原理奠定基础。中国科学院—德国马普学会计算生物学伙伴研究所杨力研究组，近期发布了升级版的环形RNA数据库网站CIRCpedia v2 (http://www.picb.ac.cn/rnomics/circpedia)，其包含了6个物种中超过180个样品的环形RNA分析数据。使用者可通过检索、浏览、下载等模块获取环形RNA基因组坐标、表达水平、可变反向剪接、人鼠保守性等多样化信息，并通过新的在线分析工具对不同样品中的环形RNA开展比较分析。这一升级版的环形RNA数据库网站为环形RNA研究提供了一个全面和综合性的平台，为深入开展环形RNA功能研究提供了数据支持和理论依据。





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