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失效原因缺失的加速失效时间模型下竞争风险数据的半参数估计

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失效原因缺失的加速失效时间模型下竞争风险数据的半参数估计 何其祥1,2, 林仁鑫31. 上海财经大学数学学院, 上海 200433;
2. 上海财经大学浙江学院, 金华 321013;
3. 中国诺华生物医药研究院有限公司生物统计部, 上海 201203 Semiparametric Analysis for Competing Risk Data under the Accelerated Failure Time Model with Missing Cause Failure HE Qixiang1,2, LIN Renxin31. School of Mathematics, Shanghai University of Finance and Economics, Shanghai, 200433, China;
2. Zhejiang College, Shanghai University of Finance and Economics, Jinhua 321013, China;
3. Biostatistics, China Novartis Institutes for Biomedical Research Co. Ltd., Shanghai 201203, China
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摘要本文在加速失效时间模型下,研究了竞争风险数据失效原因缺失情况下模型系数的估计问题。在随机缺失的假设下,利用倒概率加权和双重稳健增广技术构建估计方程,用非参数的核光滑方法估计失效原因缺失的概率。通过将估计方程转化成优化问题的方式,给出了求解估计方程的算法,研究了所提出估计量的渐近性质,通过随机模拟来评价估计量的表现,并将提出的估计方法用于研究实际的乳腺癌数据.
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收稿日期: 2018-05-25
PACS:O212.7
基金资助:国家自然科学基金(11671097),上海财经大学浙江学院发展基金(2018GR002)资助项目.

引用本文:
何其祥, 林仁鑫. 失效原因缺失的加速失效时间模型下竞争风险数据的半参数估计[J]. 应用数学学报, 2019, 42(3): 385-399. HE Qixiang, LIN Renxin. Semiparametric Analysis for Competing Risk Data under the Accelerated Failure Time Model with Missing Cause Failure. Acta Mathematicae Applicatae Sinica, 2019, 42(3): 385-399.
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