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中国科学技术大学生命学院导师教师师资介绍简介-陈宇星

本站小编 Free考研考试/2021-04-24



陈宇星,教授,博士生导师,教育部新世纪优秀人才入选者。出生于哈尔滨市。2000年-2003年在法国国家科研中心攻读博士,2003年在法国巴黎南大学获博士学位。2003-2004年在法国国家研究中心酶学与生化结构研究所作博士后研究,2004年回国到同济大学生命科学院蛋白质所任教授、博导。获选上海“浦江人才”和同济大学“三八红旗手”。现为我校生命科学学院教授、博士生导师。在JBC、Biochemical Journal、JMB和Proteins等国际期刊上发表论文三十余篇。

主要研究兴趣和项目
1.致病菌表面蛋白的结构和功能及其与宿主蛋白相互作用。(蛋白质研究项目)
2.膜蛋白的结构与功能-表达,纯化,结晶和结构解析。(自然基金委项目)
主要论文:(*corresponding author, #contributed equally)
(1) Du Y#, Shi WW#, He YX, Yang YH, Zhou CZ* and Chen Y*. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochemical Journal. 2011; DOI: 10.1042/BJ**
(2) Du Y, He YX, Zhang ZY, Yang YH, Shi WW, Frolet C, Guilmi AM, Vernet T, Zhou CZ, Chen Y*. Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae. Journal Structural Biology. 2011; 174:252-257.
(3) Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC* and Zhou CZ*. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci USA. 2010; 107(28) 12487-92.
(4) Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ*. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports. 2009; 10(12):1320-1326
(5) Bao R, Zhou CZ, Jiang C, Lin SX, Chi CW, Chen Y*. The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. Journal of Biological Chemistry.2009; 284(39):26676-84.
(6) Bao R, Chen Y*, Tang YJ, Janin J, Zhou CZ. Crystal structure of the yeast cytoplasmic thioredoxin Trx2.Proteins. 2007; 66(1): 246-249.
(7) Chen Y, Solange Morera, Claudia Pasti, Angela Angusti, Nicola Solaroli, Michel Veron, Joel Janin, Stefano Manfredini & Dominique Deville-Bonne. Adenosine phosphonoacetic acid is slowly metabolized by NDP Kinase. Medicinal Chimistry. 2005; 1(6): 529-536.
(8) Chen Y, Gallois-Montbrun S, Schneider B, Verron M, Morera S, Deville-Bonne D& Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. Journal Molecular Biology. 2003;332: 915-926.
联系方式:电话: E-mail:cyxing@ustc.edu.cn





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