宋晓元，教授，博士生导师。毕业于北京师范大学生物系，1996年和1999年分别获得学士和硕士学位。2006年在美国罗彻斯特大学生物系取得分子、细胞和发育生物学博士学位。2006-2012年在加州大学圣地亚哥分校进行博士后研究，期间获得癌症研究所博士后奖学金资助。2012年12月加入中国科学技术大学生命科学学院。多年来一直从事基因转录调控、长链非编码RNA（lncRNA）、染色质间相互作用(三维基因组结构)等相关研究，在Genes & Dev. 、Mol Cell Biol. 、Nature、PNAS等学术期刊上发表了系列文章。

主要研究方向：
1.研究由lncRNA和三维基因组结构所组成的三维转录调控在脑衰老中的作用
2.研究lncRNA和染色质相互作用在精子发生过程中的转录调控作用
3.研究减数分裂相关特定基因的功能及其分子机制

代表性学术论文：

1.LuoZ.^*, HuT.^*, JiangH.,WangR.,Xu Q., Zhang S.,Cao J.,Song X.^#. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila.Genome Research.2020. Mar 12. doi: 10.1101/gr.241687.118.^#Corresponding author.
2.Cheng Q.^*, Ouyang X.^*, Zhang R.^*, Zhu L.,Song X.^#.Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression. RNA Biology. 2020. Jan 30: 1-14. ^#Corresponding author.
3.Cao J., Jiang H.^*, Zhang R.^*, Ghanam AR.^*, Xia H., Zhu Y., Yang Z., Song X.^#. Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance.Science Bulletin. 2019. 64: 1132-1135. ^#Corresponding author.
4.Ghanam AR., Cao J., Ouyang X., and Song X.^#. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. **. eCollection 2019.^#Corresponding author.
5.Wang F.^*, Ren D.^*, Liang X.^*, Ke S., Zhang B., Hu B.^#, Song X.^#, Wang X.^#. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019,47(12): 6315-6329. ^#Corresponding author.
6.Mamun M.Al., Mannoor K., Cao J., Qadri F., Song X.^#. SOX2 in cancer stemness: Tumor malignancy and therapeutic potentials. Journal of Molecular Cell Biology. 2018. doi: 10.1093/jmcb/mjy080. ^#Corresponding author.
7.Ghanam AR., Xu Q., Ke Sh., Azhar M., Cheng Q., Song X.^#. Shining the light on senescence associated lncRNAs. Aging & Disease.2017,1; 8(2):149-161. ^#Corresponding author.
8.Xu Q., Wang R., Ghanam AR., Yan G., Miao W., Song X.^#. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49.^#Corresponding author.
9.Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.^#. Three-dimensional regulation of transcription. Protein & Cell.2015, 6(4):241-53.^#Corresponding author.
10.Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.^#. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29.
11.Song X.^*, Wang X.^*, Arai S. and Kurokawa R.^#. Promoter-associated noncoding RNA from the CCND1promoter. Methods in Molecular Biology. 2012, 809:609-22. ^*Co-first author.
12.Harismendy O.^*, Notani D.^*, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD.,Topol EJ., Rosenfeld MG^#, and Frazer KA^#. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. ^*Co-first author.
13.Wang X.^*and Song X.^*, Glass CK., and Rosenfeld MG^#. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol.20113(1):a003756. ^*Co-first author. Collected in《The RNA World》IV.
14.Wang X., Arai S.^*,Song X.^*, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.^#, Glass CK.^#, and Kurokawa R.^#. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription.Nature. 2008, 454(7200):126-30.
15.Song, X.^*, Gjoneska E.^*, Ren Q.^*, Taverna SD., Allis C.D., and Gorovsky MA.^#. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol.2007, 27(7):2648-60. ^*Co-first author.
16.Song X.and Gorovsky MA.^#. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2is down-regulated during starvation. Mol Cell Biol.2007, 27(5):1925-33.
17.Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.^#. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS.2002, 99(6):3734-9.
实验室招聘实验员、硕博研究生和本科实习生。同时招聘具有分子生物学及生物信息学等相关背景的博士后，待遇从优。
联系方式： E-mail:songxy5@ustc.edu.cn. 电话：**.
ResearcherID :http://www.researcherid.com/rid/P-1094-2014

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