姓　　名:
张隆华
地　　址:
中国科学技术大学西校区，生命科学学院518房间
邮　　编:
230027
传　　真:
86-
电　　邮:
zlhustc@ustc.edu.cn

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　教育与科研经历
1996 - 2000
中国科学技术大学 生命科学学院 本科
2000 - 2006
中国科学技术大学 生命科学学院 研究生
2006 - 2010
美国马里兰大学 医学院 博士后
2011 - present
中国科学技术大学 生命科学学院 副教授


　目前研究方向
1.
配体、辅助亚基调控离子通道功能的结构基础。
2.
通过荧光和其他生物物理方法研究膜蛋白动态构象变化。


　代表性论文
1.
Zhang M, Wen M, Xiong Y, Zhang L(*), Tian C(*). In cell measurement of fluorescent lifetime imaging microscopy revealed C-terminal conformation changes of Ferroportin upon addition of Mn²⁺, Chinese Chem Lett, 2018, 29: 1509-1512.

2.
Yu M, Liu S, Sun P, Pan H, Tian C(*), Zhang L(*). Peptide Toxins and small-molecule blockers of BK channels, Acta Pharmacol Sin, 2016, 37(1):56-66.

3.
Liu S, Lv P, Li D, Guo X, Zhang B, Yu M, Li D, Xiong Y, Zhang L(*), Tian C(*). K(+) preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine, Chem Commun (Camb), 2015, 51(88):15971-15974.

4.
Sun P, Wu F, Wen M, Yang X, Wang C, Li Y, He S, Zhang L(*), Zhang Y(*), Tian C(*). A distinct three-helix centipede toxin SSD609 inhibits I(ks) channels by interacting with the KCNE1 auxiliary subunit, Sci Rep, 2015, 5: 13399.

5.
Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L(*), Tian C(*). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells, Chem Commun (Camb), 2015, 51(38):8153-8156.

6.
Yu L, Wang W, Ling S, He Y, Xiao L, Wu K, Zhang L(*), Tian C(*). Distance measurement between two flexible sites in proteins in high viscosity medium at physiological temperature using continuous wave EPR, Protein Cell, 2014, 5(5):334-337.

7.
Zhang L, Alger BE(*). Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome, J Neurosci, 2010, 30(16):5724-9.

8.
Edward DA, Zhang L, Alger BE(*). Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus, Proc Natl Acad Sci U S A, 2008, 105(23):8142-8147.

9.
Zhang L, Gong N, Fei D, Xu L(*), XU T(*). Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology, 2008, 33(3):701-711.