刘强
单位：中国科学技术大学
地址：安徽省合肥市黄山路443号，中国科学技术大学生命科学学院344室
邮编：230027
电话：
个人主页： https://biox.ustc.edu.cn/2014/1105/c692a340157/page.htm
实验室介绍：


个人简历 Personal resume


2005年毕业于中科院生物物理所，获博士学位。曾在美国宾夕法尼亚大学，休斯医学研究所从事博士后研究，后回国。 主要研究方向： 1.学习记忆的分子神经生物学机制。 2.中枢神经系统的能量代谢调控 3.中枢神经系统脂代谢调控与肥胖糖尿病的关系； 4.脂代谢在神经退行性疾病以及衰老中的分子细胞机制； 5.非编码RNA在中枢神经系统中的作用，包括学习记忆，能量代谢等过程。


研究方向 Research direction


1、学习记忆，神经退行性疾病以及非编码RNA在神经系统中的作用
2、大脑代谢调控
3、脑衰老与神经退行性疾病



招生信息 Enrollment information





论文专著 The monograph


1).Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. - PLoS Biology - 2011 -
2)U1 snRNP Determines mRNA Length and Regulates Isoform Expression. - Cell - 2012 -
3)Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. - Journal of Neurosci, - 2010 -
4)LRP1 shedding in human brain: roles of ADAM10 and ADAM17. - Molecular Neurodegeneration - 2009 -
5)Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal A{lower case beta}42 uptake and lysosomal accumulation - PLoS One - 2010 -
6)Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase - ProcNatlAcadSci U S A - 2012 -
7)HeparanSulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-{ beta} Uptake. - Journal of Neurosci - 2012 -
8)Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis - Oncogene - 2010 -
9)Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4 - Journal of Cell Science - 2010 -
10)The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells - Journal of Biological Chemistry - 2008 -
11).LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein - Journal of Cell Science - 2008 -
12)Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain - Molecular Neurodegeneration - 2009 -
13)Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway - Journal of Biological Chemistry - 2009 -