宋晓元
单位：生命科学学院与医学部
地址：安徽省合肥市黄山路443号中国科学技术大学生命科学院
邮编：230026
电话：**
个人主页： https://biox.ustc.edu.cn/2013/0104/c692a340186/page.htm
实验室介绍： https://biox.ustc.edu.cn/2013/0104/c699a11014/page.htm


个人简历 Personal resume


，教授，博士生导师。毕业于北京师范大学生物系，1996年和1999年分别获得学士和硕士学位。2006年在美国罗彻斯特大学生物系取得分子、细胞和发育生物学博士学位。2006-2012年在加州大学圣地亚哥分校进行博士后研究，期间获得癌症研究所博士后奖学金资助。2012年12月加入中国科学技术大学生命科学学院。多年来一直从事基因转录调控、长链非编码RNA（lncRNA）、染色质间相互作用等相关研究，在Genes & Dev. 、Mol Cell Biol. 、Nature、PNAS等学术期刊上发表了系列文章。


研究方向 Research direction


1、研究由lncRNA和三维基因组结构所组成的三维转录调控在脑衰老中的作用
2、研究lncRNA和染色质相互作用在精子发生过程中的转录调控作用
3、研究减数分裂相关特定基因的功能及其分子机制



招生信息 Enrollment information





论文专著 The monograph Researcher ID


1)Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila - Genome Research - 2020 - 2020. 30(3): 406-414
2)Three-dimensional Regulation of Transcription - Protein & Cell. - 2015 - 2015 Feb 12.
3)Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis - iScience - 2020 - 2020. 23(4):101034
4)The function of lncRNAs in aging-related diseases and 3D genome - Translational Medicine of Aging - 2019 - 2019, 3: 57-63.
5)Senescence-associated genes and non-coding RNAs function in pancreatic cancer progression - RNA Biology - 2020 - 2020. Jan 30: 1-14
6)A long noncoding RNA cluster-based genomic locus maintains proper development and visual function - NUCLEIC ACIDS RESEARCH - - 0305-1048
7)Enhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program. - PNAS. - 2015 - 2015, 112(5): 1380-1385
8)New insights into chronological mobility of retrotransposable elements in vivo - Oxidative Medicine and Cellular Longevity - - 1942-0900
9)Trans-Recruitment of a DNA-Binding Transcription Factor Complex Is Required for Activation of ERα-bound Enhancers - Cell. - 2014 - 2014, 159(2):358-73.
10)Epigenomic Profiling Identifies the Role of Nr5a2 and CYP1B1 in Hepatocellular Carcinoma Stemness Maintenance - Science Bulletin - - 2095-9273
11)Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation - Nature. - 2013 - 2013, 498(7455):516-20.
12)Mechanisms of three-dimensional transcriptional regulation in cell senescence - SCIENTIA SINICA Vitae - -
13)Promoter-Associated Noncoding RNA from the CCND1 promoter - Methods in Molecular Biology. - 2012 - 2012, 809:609-22.
14)The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation - GENES & DEVELOPMENT - 2012 - 2012, 26(6):615-29.
15)9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response - NATURE - 2011 - 2011, 470(7333):264-8.
16)The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs - COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY - 2011 - 2011 3(1):a003756.
17) Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription - NATURE - 2008 - 2008, 454(7200):126-30.
18)Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila - MOLECULAR AND CELLULAR BIOLOGY - 2007 - 2007, 27(7):2648-60.
19)Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation - MOLECULAR AND CELLULAR BIOLOGY - 2007 - 2007, 27(5):1925-33.
20)The H1 Phosphorylation State Regulates Expression of CDC2 and Other Genes in Response to Starvation in Tetrahymena thermophila. - Mol Cell Biol. - 2005 - 2005, 25(10):3914-22.
21)Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent. - Eukaryot Cell. - 2005 - 2005, 4(2):421-31.
22)A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression,and overexpression of homologous and heterologous genes in Tetrahymena thermophila. - PNAS. - 2002 - 2002, 99(6):3734-9.
23)A long noncoding RNA cluster-based genomic locus maintains proper development and visual function - Nucleic Acids Research - 2019 - 2019, 47(12): 6315-6329
24)piRDisease v1.0: a manually curated database for piRNA associated diseases - Database (Oxford) - 2019 - 2019. Jan 1: baz052
25)New insights into chronological mobility of retrotransposable elements in vivo - Oxidative Medicine and Cellular Longevity - 2019 - 2019. **
26)Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance - Science Bulletin - 2019 - 2019. 64: 1132-1135
27)Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain - Cell - 2018 - 2018, 6; 173(7):1716-1727
28)SOX2 in cancer stemness: Tumor malignancy and therapeutic potentials - Journal of Molecular Cell Biology - 2018 - 2018. doi: 10.1093/jmcb/mjy080
29)Mechanisms of three-dimensional transcriptional regulation in cell senescence - SCIENTIA SINICA Vitae - 2017 - 2017, 47(1), 26-35
30)Shining the light on senescence associated lncRNAs - Aging & Disease - 2017 - 2017, 1; 8(2):149-161
31)The key role of CYC2 during meiosis in Tetrahymena thermophile - Protein & Cell - 2016 - 2016, 7(4):236-49
32)The ideal composer of the melody for life - Biomedical Science - 2016 - 2016, 2(2): 11-15
33)Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation - Mol Cell - 2015 - 2015，59(2):188-202
34)Hepatocellular Carcinoma-propagating Cells are Detectable by Side Population Analysis and Possess an Expression Profile Reflective of a Primitive Origin - Scientific Reports - - 2045-2322
35)piRDisease 1.0: A manually curated database for piRNA associated diseases - Database-The Journal of Biological Databases and Curation - - 1758-0463
36)New insights into chronological mobility of retrotransposons in vivo - Oxidative Medicine and Cellular Longevity - - 1942-0900
37)Three-dimensional regulation of transcription - Protein & Cell - - 1674-800X
38)A selective and sensitive peptide-based fluorescent chemical DSH sensor for detection of zinc ions and application in vitro and in vivo - NEW JOURNAL OF CHEMISTRY - - 1144-0546
39)The key role of CYC2 during meiosis in Tetrahymena thermophila - Protein & Cell - - 1674-800X
40)SOX2 in Cancer Stemness: Tumor Malignancy and Therapeutic Potentials - Journal of Molecular Cell Biology - - 1674-2788