姓名：洪波
地址：科学岛
类型：硕导
所在科研单元：健康所


导师介绍



洪波，副研究员，硕士生导师。2009年于香港中文大学获得博士学位。2010-2015年先后在宾夕法尼亚州立大学和美国国立卫生研究院从事博士后研究。研究领域是小细胞肺癌靶向治疗以及肿瘤基因组学的研究。目前在Cancer Research , Curr Opin Genet Dev、Biochemical Pharmacology等期刊上发表SCI论文20多篇。

Introduction





研究领域



本人主要从事小细胞肺癌靶向治疗以及肿瘤基因组学的研究

招生专业



学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：肿瘤生物学专业学位硕士招生计划：          1、专业：生物与医药（专硕）招生方向：肿瘤药物学学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：肿瘤生物学          2、专业：生物物理学（硕士）招生方向：肿瘤药物学专业学位硕士招生计划：          1、专业：生物与医药（专硕）招生方向：肿瘤生物学          2、专业：生物与医药（专硕）招生方向：肿瘤药物学学术硕士招生计划：          1、专业：生物物理学（硕士）招生方向：肿瘤生物学          2、专业：生物物理学（硕士）招生方向：肿瘤药物学

研究成果



Hong B, Prabhu VV, Zhang S, van den Heuvel AP, Dicker DT, Kopelovich L, El-Deiry WS. (2014) Prodigiosin rescue deficient p53 signaling and anti-tumor effects via p73 up-regulation and disruption of mutant p53:p73 interaction. Cancer Research. 74(4):1153-1165.
Hong B, Le Gallo M, Bell DW. (2015) The mutational landscape of endometrial cancer. Curr Opin Genet Dev. 30C:25-31.
Hong B*, Lui VW*, Hui EP, Lu Y, Leung HS, Wong EY, Cheng SH, Ng MH, Mills GB, Chan AT. (2010) Reverse Phase Protein Array Identifies Novel Anti-invasion Mechanisms of YC-1. Biochemical Pharmacology. 79(6):842-852, (*denotes co-first authorship).
Hong B, Wang H, Deng K, Wang W, Dai H, Lui VWY, Lin W. (2017) Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. Oncotarget. 4;8(63):106486-106498.
Wang H*, Hong B*, Li X, Deng K, Li H, Yan Lui VW, Lin W. (2017) JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer. Oncotarget. 8(49):86312-86324, (*denotes co-first authorship).
Hong B, van den Heuvel AP, Prabhu VV, Zhang S, El-Deiry WS. (2014) Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities. Current Drug Targets. 15(1):80-89.
Hong B, Lui VW, Hashiguchi M, Hui EP, Chan AT. (2013) Targeting tumor hypoxia in nasopharyngeal carcinoma. Head & Neck. 35(1):133-145.
Hong B*, Lui VW*, Hui EP, Ng MH, Cheng SH, Sung FL, Tsang CM, Tsao SW, Chan AT. (2011) Hypoxia-targeting by Tirapazamine (TPZ) Induces Preferential Growth Inhibition of Nasopharyngeal Carcinoma Cells with Chk1/2 Activation. Investigational new drugs. 29(3):401-410, (*denotes co-first authorship).
Hong B, Zhang ZF, Tang SM, Yi YZ, Zhang TY, Xu WH. (2006) Protein-DNA interactions in the promoter region of the gene encoding diapause hormone and pheromone biosynthesis activating neuropeptide of the cotton bollworm, Helicoverpa armigera. Biochim Biophys Acta. 1759(3-4):177-185.
Prabhu VV, Hong B, Allen JE, Zhang S, Lulla A, Dicker DT, El-Deiry WS. (2016) Small molecule prodigiosin restores p53 tumor suppressor activity in chemoresistant colorectal cancer stem cells via c-Jun-mediated ΔNp73 inhibition and p73 activation. Cancer Research. 76(7):1989-99.
Zhang S, Zhou L, Hong B, van den Heuvel AP, Prabhu VV, Warfel NA, Kline CL, Dicker DT, Kopelovich L, El-Deiry WS. (2015) Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Research. 75(18):3842-52.