何晓燕 职称：副教授
学历：博士
邮箱：hexiaoyan@ahmu.edu.cn
地址：合肥市梅山路81号，安徽医科大学，知行楼B座，230032



个人简介
科研领域
代表性论文
研究课题

2019.07-至今 安徽医科大学生命科学院，校聘副教授
2014.09-2019.06 武汉大学化学与分子科学学院，博士
2010.09-2014.06 湖北师范大学化学与化工学院，学士



恶性肿瘤是威胁人类健康最主要的疾病之一，本实验室的研究工作主要聚焦于肿瘤的诊断和治疗方面。近期的研究方向主要集中于以下三点：
1. 新型药物和基因传递系统的研究；
2. 疾病的诊断和治疗新材料的开发；
3. 通过研究肿瘤的发生的机制、肿瘤微环境与肿瘤恶化的关系，探索一些新型的肿瘤治疗思路。



1. He X, Ren X, Peng Y, Zhang J, Ai S, Liu B, Xu C, Cheng S. Aptamer/peptide-functionalized genome-editing system for effective immune restoration through reversal of PD-L1-wediated cancer immunosuppression. Adv. Mater., 2020, 32(17): e**.
2.He X, Liu B, Yan P, Zhuo R, Cheng S. A multi-functional vector for delivery of genome editing plasmid targeting β-Catenin to re-modulate cancer cell properties. ACS Appl. Mater. Interfaces,2019, 11(1): 226-237.

3.He X, Liu B, Xu C, Zhuo R, Cheng S. A multi-functional macrophage and tumor targeting gene delivery system for regulation of macrophage polarity and reversal of cancer immunoresistance. Nanoscale,2018, 10(33): 15578-15587.
4.He X, Liu B, Wu J, Ai S, Zhuo R, Cheng S. A dual macrophage targeting nanovector for delivery of oligodeoxynucleotides to overcome cancer-associated immunosuppression. ACS Appl. Mater. Interfaces, 2017, 9(49): 42566-42576.
5.He X, Liu B, Ai L, Xu L, Zhuo R, Cheng S. Functional polymer/inorganic hybrid nanoparticles for macrophage targeting delivery of oligodeoxynucleotides in cancer immunotherapy. Mater.Today Chem., 2017, 4: 106-116.
6. Liu B, He X, Zhuo R, Cheng S. Reversion of tumor malignization and modulation of cell behaviors through genome editing mediated by a multi-functional nanovector. Nanoscale, 2018, 10(45): 21209-21218.
7. Liu B, He X, Cheng S, Zhuo R. Tumor targeted genome editing mediated by a multi-functional gene vector for regulating cell behaviors. J. Controlled Release, 2018, 291: 90-98.
8. Liu B, He X, Xu C, Xu L, Ai S, Cheng S, Zhuo R. A dual-targeting delivery system for effective genome editing and in situ detecting related protein expression in edited cells. Biomacromolecules, 2018, 19(7): 2957-2968.
9. Wu J, He X, Liu B, Gong M, Zhuo R, Cheng S. Fusion peptide functionalized hybrid nanoparticles for synergistic drug delivery to reverse cancer drug resistance. J. Mater. Chem. B, 2017, 5(24): 4697-4704.
10. Chen B, He X, Yi X, Zhuo R, Cheng S. Dual-peptide-functionalized albumin-based nanoparticles with pH-dependent self-assembly behavior for drug delivery. ACS Appl. Mater. Interfaces, 2015, 7(28): 15148-53.



1. 安徽医科大学引进人才科研启动项目，2019/09-2024/09，主持
2. 安徽医科大学校科研启动项目，2020/01-2021/12，主持