summary
工作经历:
教育经历:
研究方向：
1、神经退行性疾病，尤其是阿尔茨海默症（Alzheimer’s disease, AD）的发病机理、调控、预防以及早期诊断；
2、神经干细胞，尤其是成年哺乳动物脑中神经干细胞的发育、功能调控及其与神经系统疾病的关系。
template_id
1
photo
\/attachments\/74\/-.jpg
research_field
status
1
opendate
2011-05-11 12:04:58
access_type
access_count
31288
score
connect
selfintroduction
工作经历
\r2010 - 浙江大学医学院神经科学研究所，教授
\r2005 - 2010 加州大学旧金山分校Gladstone研究所，博士后
\r1997 - 2002 中国农业大学，助教、讲师
\r
\r
\r教育经历
\r2002 - 2005 理学博士，埼玉大学，日本
\r1994 - 1997 理学硕士 , 中国农业大学
\r1990 - 1994 学士，河北农业大学
\r
\r
\r研究方向：
\r1、神经退行性疾病，尤其是阿尔茨海默症（Alzheimer’s disease, AD）的发病机理、调控、预防以及早期诊断；
\r2、神经干细胞，尤其是成年哺乳动物脑中神经干细胞的发育、功能调控及其与神经系统疾病的关系。
\r
\r
\r发表论文：
\r
\r\r Zhang H, Zhang L, Zhou D, He X, Wang D, Pan H, Zhang X, Mei Y, Qian Q, Zheng T, Jones FE, Sun B*.Ablating ErbB4 in PV neurons attenuates synaptic and cognitive deficits in an animal model of Alzheimer's disease. Neurobiol Dis 2017, 106: 171-180. *Corresponding author
\r
\r Qian Q, Zhou D, Liu Q, Pan H, Liu Z, He F, Ji S, Wang D, Bao W, Liu X, Liu Z, Zhang H, Zhang X, Zhang L, Wang M, Xu Y, Huang F, Luo B*, Sun B*. Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway. FASEB J 2017, 31(5): 2104-2113. *Correspondence
\r
\r Pan H, Wang D, Zhang X, Zhou D, Zhang H, Qian Q, He X, Liu Z, Liu Y, Zheng T, Zhang L, Wang M, Sun B*. Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein. Stem Cell Reports 2016, 7(4):707-718. * Corresponding author
\r
\r Chung MM, Chen YL, Pei D, Cheng YC, Sun B, Nicol CJ, Yen CH, Chen HM, Liang YJ, Chiang MC. The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent. Biochim Biophys Acta-Molecular Basis of Disease 2015, 1852(5):720-731.
\r
\r 何晓, 孙秉贵. 小胶质细胞及免疫相关受体在老年痴呆症中的作用研究进展. 药学学报, 2014, 49(6): 774-780.
\r
\r 刘运进，潘洪玉，孙秉贵. 老年痴呆症的突触和神经环路机制. 生命科学 2014, 26(1): 35-43.
\r
\r Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV Jr. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest 2012, 122(11):3955-3959.
\r
\r Wang C*, Sun B*, Zhou Y, Grubb A, Gan L. Cathepsin B degrades amyloid-β in mice expressing wildtype human amyloid precursor protein. J Biol Chem 2012, 287(47):39834-39841. *Equal contribution
\r
\r Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreanig P, Mucke l, Desai T, Gan L. Selective targeting of microglia by quantum dots. J Neuroinflammation 2012, 9(1):22.
\r
\r Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem 2011, 286: 32713-32722.
\r
\r Cisse M, Halabisky B, Harris J, Devidze N, Dubal D, Sun B, Orr A, Lotz G, Kim D, Hamto T, Ho K, Yu G, Mucke L. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature 2011, 469: 47-52 (Article).
\r
\r Sun B*, Halabisky B*, Zhou Y, Yu G-Q, Mucke L, Gan L. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell 2009, 5: 624-633 (cover story). *Equal contribution
\r
\r Sun B*#, Mochiduki A*, Kimie Nakamura, Yokoyama K, Adachi S, Fujiwara K, Matsumoto H,Inoue K. Blockade of PrRP attenuates MPTP-induced toxicity in mice. Peptides 2009, 30:1267-1275. * Co-first author, #Corresponding author
\r
\r Sun B, Zhou Y, Halabisky B, Lo I, Cho S, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 2008, 60:247–257.
\r
\r Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 2006, 51: 703-714.
\r
\r Adachi S, Mochiduki A, Nemoto H, Sun B, Fujiwara K, Matsumoto H, Inoue K. Estrogen suppresses the stress response of prolactin-releasing peptide-producing cells. Neuroscience Letters 2005, 380: 311-315
\r
\r Sun B, Nemoto H, Fujiwara K, Adachi A, Inoue K. Nicotine stimulates prolactin-releasing peptide (PrRP) cells and non-PrRP cells in the solitary nucleus. Regulatory Peptides 2005,126: 91-96
\r
\r Sun B, Gan L. Manipulation of gene expression in the central nervous system with lentiviral vectors. Methods Mol Biol 2011, 670:155-168
\r
\r Sun B, Fujiwara K, Adachi A, Inoue K. Physiological roles of prolactin-releasing peptide. Regulatory Peptides 2005, 126: 27-33
\r\r
\r
\r联系方式：\r孙秉贵
\r浙江大学神经科学研究所
\r联系电话:
\rEmail：bsun@zju.edu.cn
\r
\r
\r
\r
\r
\r
\r
\r
url
telephone
bsun@zju.edu.cn
address
医学院科研楼A610
research
mypage_id
4383
work_title
learn_degree
work_post
research_orientation
handle
sunbg
main_status
1
access_uid_status
1
theme_id
qrcode_status
1
gmt_qrcode
2021-01-25 07:18:27
content
工作经历:
教育经历:
研究方向：
1、神经退行性疾病，尤其是阿尔茨海默症（Alzheimer’s disease, AD）的发病机理、调控、预防以及早期诊断；
2、神经干细胞，尤其是成年哺乳动物脑中神经干细胞的发育、功能调控及其与神经系统疾病的关系。
column_name
个人简介
