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浙江大学生命科学学院导师教师师资介绍简介-王金福

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Dr. Jinfu Wang ProfessorInstiture of Cellular BiologyCollege of Life ScienceZhejiang UniversityHangzhou, 310058, P. R. China86- (O)86- (H and Fax)wjfu@zju.edu.cn EducationPH. D. Zhejiang Agricultural University 1991M.S. Zhejiang Agricultural University, 1984B.S. Zhejiang Agricultural University, 1981
Scientific Concurrent Postion
2014-: The member of Editorial Board for "Journal of Transplantation & Stem Cell Biology"
2013-: Senior Editor for Journal “American Journal of Stem Cells”
2010-2012: Editor-in-Chief forJournal “Advances in Bioscience and Biotechnology”
2011-: The member of Editorial Board for “Journal of TransplantationTechnologies&Research”
2011-: The member of Editorial Board for “Chinese Journal of Cell and Stem Cell”
2009-: The Member of Editorial Boardfor Journal “WorldJournal of Stem Cells”
2010-: The Chief Expert for Journal “Journal of Clinical Rehabilitative Tissue Engineering Research”
2006-: The Member of Editorial Board for Journal “Acta Parasitologica et Medica Entomologica Sinica”
Professional Experience1985-1988: Assistant Researcher, Institute of Plant Protection, Zhejiang Agricultural Academy1991-1997: Associate Researcher, Institute of Parasitology, Zhejiang Medical Academy1997-1999: Associate Professor, College of Life Sciences, Hangzhou University1999-: Professor, College of Life Sciences, Zhejiang University2002: Visiting Scholar, BMT Lab, University of Colorado Health Science Center2005: Visiting Scholar, Institution of Biochemistry and Molecular Biology, University of Southern Denmark
Research InterestsBiologies of human bone marrow mesenchymal stem cells (hMSCs) and human hematopoietic stem cells (hHSCs).Effects of gravity and microgravity on the in vivo differentiation and expension of hMSCs and hHSCs.
Tissue engineering based on hMSCs.Selected Publications1. Huang ZH, Wang JF. 2000. A novel estrogen-ER beta. Chinese Bulletin of Life Sciences, 12: 126-129.
2. Huang HF, Mershon JL, Wang JF. 2000. Sequencing and cloning of human estrogen-beta receptor cDNA in human granulosa. Natl Med J China, 80: 28-30.
3. Wang JF, Wang LJ, Harrintong J, McNiece IK. 2003. Effects of bone marrow-derived mesenchymal stem cell layer on expansion and differentiation of hematopoietic stem cells from cord blood. J Zhejiang Univer, 30: 93-97.
4. Wang JF, Qiu LY, Harrintong J, McNiece IK. 2003. Study of ex vivo expansion of mouse hematopoietic stem\/progenitor cells and the use of them for hematopoiesis reconstitution. Chinese Jouranl of Hematology, 24: 584-588.
5. Qiu LY, Wang JF. 2003. Advances of studies on mesenchymal stem cells. Chinese Journal of Biotechnology, 19: 136-140.
6. Zhang SZ, Wang W, Chen GM, Wang JF, Xiang Y. 2003. Cryomicroscope and its use in the observation of intracellular ice. Cellular Biology, 2003: 231-234.
7. Wang JF, Wu YF, Harrintong J, McNiece JK. 2004. Effects of expanded hematopoietic stem \/ progenitor cells on mouse hematopoietic recovery--rapid hematopoietic recovery, long term engraftment and endogenous recovery. J Zhejiang Univer, 38: 368-372.
8. Wang JF, Wu YF, Harrintong J, McNiece JK. 2004. Ex vivo expansions and transplantations of mouse bone marrow-derived hematopoietic stem\/progenitor cells. J Zhejiang Univer, 5: 157-163.
9. Huang ZH, Hua D, Li LH, Wang JF. 2004. Ex vivo pansion of cytokine-induced natural killer cells from tumpr patients for autologous therapy. J Microbiol Immunol, 2: 205-209.
10. Lai PP, Han CM, Jin HH, Wang JF. 2004. The isolation and culture of mesenchymal stem cells from human bone marrow and their biological properties. Zhejiang Medicine, 26: 328-330.
11. Huang ZH, Li LH, Hua D, Wang JF. 2004. Study on expansion of CD56+ cytotoxic lymphocytes from human umbilical cord blood. Acta Univer. Med. Nanjing (Natural Science), 24: 612-614.
12. Wang JF, Wang LJ, Xiang Y, Wu YF, Xie CG, Jia BB, Huang GP, Harrington J, MvNiece IK, 2004. Ex vivo expansion and transplantation of mouse bone marrow-derived hematopoietic stem\/progenitor cells supported by an adherent cell feeder layer from human umbilical cord blood. Stem Cell and Cellular Therapy, 2: 18-26.
13. Qiu LY, Wang JF, Shen D, Jin J. 2004. Expansion and chondrogenic induction of human bone marrow mesenchymal stem cells. J Zhejiang Univer, 31: 337-342.
14. Xiang Y, Wang JF. 2004. Effects of Chinese drugs on proliferation and differentiation of hematopoietic stem\/progenitor cells. Chinese J. Intergrated traditional Western Medicine, 24: 666-669.
15. Wang JF, Wang LJ, Wu YF, Xiang Y, Xie CG, Jia BB, Harrington J, McNiece. 2004. Mesenchymal stem cells in human umbilical cord blood as support for ex vivo expansion of CD34+ hematopoietic stem cells and for chondrogenic differentiation. Haematologica, 89: 837-843.
16. Zhang SZ, Wang W, Zhou XL, Chen GM, Hu JX, Wang JF, Xiang Y, Yin HB. 2004. Experimental study on osmotic properties of human cord blood stem cells. J Biomathematics, 19: 26-30.
17. Wang LJ, Zhang YP, Wang JF, Wu YF, Xiang Y, Xie CG, Jia BB, Harrington J, McNiece IK. 2005. Biological charateristics of mesenchymal stem cells in human umbilical cord blood and their supporting capacities in ex vivo expansion of CD34+ hematopoietic stem cells. Chin J Hematol, 26: 65-69.
18. Wang JF, Xiang Y, Xie CG, Jia BB. 2005. Experimental study of ex vivo expanded hematopoietic stem\/progenitor in the two step culture from human umbilical cord blood transplanted into NOD\/SCID mice. J Zhejiang Univer, 32: 448-451.
19. Wang LJ, Wang JF, Wu YF, Xiang Y, Xie CG, Jia BB, Yan JN, Zhu XF. 2005. Adherent cell layer from human umbilical cord blood and its support to ex vivo expansion of hematopoietic stem\/progenitor cells. J Zhejiang Univer, 32: 433-437.
20. Xie CG, Wang JF, Xiang Y, Qiu LY, Jia BB, Wang LJ, Wu YF, Wang GZ, Huang GP. 2005. Human bone marrow mesenchymal stem cells transduced with TPO\/FL genes as support for ex vivo expansion of hematopoietic stem\/progenitor cells from human cord blood. Mol Cell Life Sci, 62: 2495-2507.
21. Xie CG, Wang JF, Xiang Y, Qiu LY, Jia BB, Wang LJ, Wu YF, Wang GZ, Huang GP. 2006. Cocultivation of umbilical cord blood CD34+ cells with retro-transduced hMSCs leads to effective amplification of long-term culture-initiating cells. World J Gastroenetrol, 12: 393-402.
22. Xie CG, Jia BB, Xiang Y, Wang JF, et al. 2006. Support of hMSCs transducted with TPO\/FL genes to expansion of umbilical cord CD34+ cells in indirect co-culture. Cell and Tissue Res, 326: 101-110.
23. Xiang Y, Wang JF, Shen D, Zheng Q, Xie CG, Jia BB, Huang GP, Jin J. 2007. Ex vivo expansion and differentiation pluripotential of cryopreserved human bone marrow mesenchymal stem cells. International Journal of Cellular Biology, 31: 444-450.
24. Zheng Q, Huang GP, Yang JF, Wang JF, et al. 2007. Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways? Biological Chemistry, 388: 755-763.
25. Wang GZ, Huang GP, Yin GL, Zhou, G, Guo CJ, Xie CG, Jia BB, Wang JF. 2007. Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. Cellular Physiology and Biochemistry, 20: 205-212.
26. Huang GP, Pan ZJ, Jia BB, Zheng Q, Xie CG, Gu JH, McNiece IK, Wang JF. 2007. Ex vivo expansion and transplantation of hematopoietic stem\/progenitor cells supported by mesenchymal stem cells form human umbilical cord blood. Cell Transplantation, 16: 579-585.
27. Huang ZH, Li LH, Wang JF. 2007. Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions. Dig Dis Sci, 52: 2287-2291.
28. Pan ZJ, Yang JF, Guo CJ, Wang JF. 2008. Effects of hindlimb unloading on ex vivo growth and osteogenic\/adipogenic potentials of bone marrow-derived mesenchymal stem cells in rats. Stem Cells and Devel, 17: 795-804.
29. Huang GP, Pan ZJ, HUang JP, Wang JF, et al. 2008. Proteomic analysis of human bone marrow mesenchymal stem cells transduced with human telomerase reverse transcriptase gene during proliferation. Cell Prolif, 41: 625-644.
30. Huang GP, Zheng Q, Sun J, Wang JF. 2008. Stabilization of cellular properties and differentiation multipotential of human mesenchymal stem cells transduced with hTERT gene in a long-term culture. J Cell Biochem, 103: 1256-1269.
31. Zhao HG, Ma L, Gao CY, Wang JF. 2009. Fabrication and properties of injectable beta-tricalcium phosphate particles\/fibrin gel composite scaffolds for bone tissue engineering. Mater Sci Eng C, 29: 836-842.
32. Ma D, Chen HW, Shi DY, Wang JF. 2009. Preparation and characterization of thermo-responsive PDMS surface grafted with poly N-isopropylacrylamide by benzophenone-initiated photolymerization. J Colloid Sci, 332: 85-90.
33. Chen R, Lu SH, Tong QB, Lou D, Shi DY, Jia BB, Huang GP, Wang JF. 2009. Protective effect of DNA-mediated immunization with liposome-encapsulated GRA4 against infection of Toxoplasma gondii. J Zhejiang Univ Sci B, 10: 512-521.
34. Xu YL, Yu ML, Wu FB, Sun JG, Wood C, Hattori MA, Wang JF, Xi YM. 2009. Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells. J Exp Zool, 312B: 872-884.
35. Yang JF, Cao C, Wang W, Tong XM, Shi DY, Wu FB, Zheng Q, Guo CJ, Pan ZJ, Gao CY, Wang JF. 2010. Proliferation and osteogenesis of immortalized bone marrow-derived mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture. J Biomed Mater Res A, 92A: 817-829.
36. Shi DY, Ma D, Dong FQ, Zong C, Liu LY, Shen D, Yuan WJ, Tong XM, Chen HW, Wang JF. 2010. Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermo-responsive PDMS surfaces grafted with PNIPAAm. Biosci Rep, 30: 149-158.
37. Liu LY, Yuan WJ, Wang JF. 2010. Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress. Biomech Model Mechanobio, 9:659-670.
38. Zong C, Xue DT, Yuan WJ, Wang W, Shen D, Tong XM, Shi DY, Liu LY, Zheng Q, Gao CY, Wang JF. 2010. Reconstruction of rat calvarial defect with human mesenchymal stem cells and osteoblast-like cells in poly-lactic-co-glycolic acid scaffolds. Eur Cells Mater, 20: 109-120.
39. Shi DY, Meng R, Deng WL, Ding WC, Zheng Q, Yan WJ, Liu LY, Zong C, Shang P, Wang JF. 2010. Effects of microgravity modeled by large gradient high magnetic field on the osteogenic initation of human mesenchymal stem cells. Stem cell Rev Rep, 6: 567-578.
40. Meng R, Xu HY, Di SM, Shi DY, Qian AR, Wang JF, Shang P. 2011. Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. Acta Biochem Biophys Sin, 43: 133-142.
41. Guo CJ, Gao Y, Hou D, Shi DY, Tong XM, Shen D, Xi YM, Wang JF. 2011. Preclinical transplantation and safety of HS\/PCs expanded from human umbilical cord blood. World J Stem Cells, 3: 43-52.
42. Liu LY, Shao L, Li B, Zong C, Li JH, Zheng Q, Tong XM, Gao CY, Wang JF. 2011. Extracellular signal-reglated kinase 1\/2 activated by fluid shear stress promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through novel signaling pathways. Int J Biochem Cell Biol, 43: 1591-1601.
43. "Effects of Helicobacter Pylori and Non-Steroidal Anti-Inflammatory Drugs on Peptic Ulcer" in 《Petic Ulcer Disease》edited by Jianyuan Chai Published by InTechOpen, June 2011, pp. 29-38.
44. Wang JF, Zong C, Shi DY, Wang W, Shen D, Liu LY, Tong XM, Zheng Q, Gao CY. 2012. Hepatogenic engineering from human bone marrow mesenchymal stem cells in porous polylactic glycolic acidscaffolds under perfusionculture. J Tissue Eng Regen Med, 6: 29-39.
45. Liu LY, Yu B, Chen JR, Tang ZH, Zong C, Shen D, Zheng Q, Tong XM, Gao CY, Wang JF. 2012. Different effects of intermittent and continous fluid shear stresses on osteogenic differentiation of human mesenchymal stem cells. Biomech Model Mechanobiol, 11: 391-401.
46. Jia BB, Madsen L, Petersen RK, Techer N, Kopperud R, Mao T, Doskeland SO, Ailhaud G, Wang JF, Amri EZ, Kristiansen K. 2012. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PlosOne, 7: 34114-34124.
47. Tang ZH, Shi DY, Jia BB, Chen JR, Zong C, Shen D, Zheng Q, Wang JF, Tong XM. 2012. Exhange protein activated by cyclic adenosine monophosphate regulates the switch between adipogenesis and osteogenesis of human mesenchymal stem cells through increasing the activation of phosphatidylinositol 3-kinase. Int J Biochem Cell Biol, 44: 1106-1120.
48. Yuan WJ, Zong C, Huang YZ, Gao Y, Shi DY, Chen CS, Liu LY, Wang JF. 2012. Biological, immunological and regenerative characteristics of placenta-derived mesenchymal stem cells isolated using a time-gradient attachment method. Stem Cell Res, 9: 110-123.
49. Zong C, Qian XD, Tang ZH, Hu QH, Chen JR, Gao CY, Tang RK, Tong XM, Wang JF. 2013. Biocompatibility and bone-repairing effects: Comparison between porous poly-lactic-co-glycolic acid and nano-hydroxyapatite \/poly(lactic acid) scaffolds. J Biomed Nanotechnol, 9:1-14.
50. Chen J, Zhang C, Feng YD, Zong C, Chen JR, Tang ZH, Jia BB, Tong XM, Zheng Q, Wang JF. 2013. Studies on culture and osteogenic induction of human mesenchymal stem cells under CO2-independent conditions. Astrobiology, 13: 370-379.
51. Dai ZQ, Wu F, Chen J, Xu HJ, Wang HH, Guo FM, Tan YJ, Ding B, Wang JF, Wan YM, Li YH. 2013. Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity. PlosOne, 8: 63661-63670.
52. Liu LY, Zong C, Li B, Shen D, Tang ZH, Chen JR, Zheng Q, Tong XM, Gao CY, Wang JF. 2014. The interaction between belta1intergrins and ERK1\/2 osteogenic differentiation of human mesenchymal stem cells under fluid shear stress modeled by perfusion system. J Tissue Eng Regen Med, 8: 85-96.
53. Liu QW, Chen P, Wang JF. 2014. Molecular mechanisms and potentials for differentiating inner ear stem cells into seneory hair cells. Developmental Biology, 390: 93-101.

54. Qian XD, Zhang C, Chen GJ, Tang ZH, Liu QW, Chen JR, Tong XM, Wang JF. 2014. Effects of BMP-2 and FGF2 on the osteogenesis of bone marrow-derived mesenchymal stem cells in hindlimb-unloaded rats. Cell Biochem Biophys, 70:1127–1136.
55. Zhang C, Li L, Chen JL, Wang JF. 2015. Behavior of stem cells under outer-space microgravity and ground-based microgravity simulation. Cell Biology International, 2015: 1-10.
56. Liu QW, Chen JR, Gao XL, Ding J, Tang ZH, Zhang C, Chen JL, Li L, Chen P, Wang JF. 2015. Identification of stage-specific markers during differentiation of haircells from mouse inner ear stem cells or progenitor cells in vitro. International Journal of Biochemistry & Cell Biology, 60:99-111.
57. Liu QW, Shen Y, Chen JR, Ding J, Tang ZH, Zhang C, Chen JL, Li L, Chen P, Wang JF. 2016. Induction of functional hair-cell-like cells from mouse cochlear multipotent. Cells Stem Cells International, 2016: 1-14.
58. Chen JR, Tang ZH, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF. 2016. Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation. Cell Death and Differentiation, 23: 1347–1357.
59. Tang ZH, Chen JR, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF. 2016. Genetic correction of induced pluripotent stem cells from a deaf patient with MYO7A mutation results in morphologic and functional recovery of the derived hair cell-like cells. Stem Cells Translational Medicine, 5: 561-571.
60. Ding J, Tang ZH, Chen JR, Shi HS, Chen JL, Wang CC, Zhang C, Li L, Chen P, Wang JF. 2016. Induction of differentiation of human embryonic stem cells intofunctional hair-cell-like cells in the absence of stromal cellsJie International Journal of Biochemistry & Cell Biology, 81: 208-222.
61. Chen J, Li K, Pang QQ, Yang C, Zhang HY, Wu F, Cao HQ, Liu HJ, Wan YM, Xia WB, Wang JF, Dai ZQ, Li YH. 2016. Identification of suitable reference gene and biomarkers of serum miRNAs for osteoporosis. Scientific Reports, 6: 36347.
62. Chen LJ, Zhang CF, Chen L, Wang XJ, Xiang BY, Wu XX, Guo Y, Mou XZ, Yuan L, Chen B, Wang JF, Xiang C. 2017. Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators. Stem Cells Translational Medicine, 6: 272-284.
63. Zong C, Wang MC, Yang FC, Chen GJ, Chen JR, Tang ZH, Liu QW, Gao CY, Ma L, Wang JF. 2017. A novel therapy strategy for bile duct repair using tissue engineering technique: PCL\/PLGA bilayered scaffold with hMSCs. J Tissue Eng Regen Med, 11: 966–976
64. Zhang C, Hong FF, Wang CC, Li L, Chen JL, Liu F, Quan RF, Wang JF. 2017. TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1\/2 signaling pathway. Scientific Reports, 7: 10342.
65. Zong C, Wang MC, Yang FC, Chen GJ, Chen JR, Tang ZH, Liu QW, Gao CY, Ma L, Wang JF. 2017. A novel therapy strategy for bile duct repair using tissue engineering technique: PCL\/PLGA bilayered scaffold with hMSCs. J Tissue Eng Regen Med, 11: 966–976
66. Zhang C, Hong FF, Wang CC, Li L, Chen JL, Liu F, Quan RF, Wang JF. 2017. TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1\/2 signaling pathway. Scientific Reports, 7: 10342.

浙江大学生命科学学院教授、博士生导师,浙江大学细胞与遗传学研究所副所长。教学方面从事本科生《生物化学》、《高级生物化学》、《分子生物学》和《生命科学与技术导论》等课程以及研究生《细胞分子生物学》和《细胞发育生物学》等课程教学;科研方面从事造血干细胞和骨髓间充质干细胞扩增、分化及其相关分子机理研究,并开展基于人骨髓间充质干细胞的组织工程技术以及太空微重力环境影响干细胞分化与发育的分子机制研究。先后发表论文70多篇,其中31篇为SCI收录,2篇为EI收录。获国家科技成果二等奖1项、浙江省科技成果一等奖1项、二等奖2项、三等奖3项,申请技术发明专利13项,获授权8项。1999年获浙江省“151”跨世纪人才第一层次入选人员称号。2002年和2005年分别在美国科罗拉多医学科学中心和南丹麦大学从事合作研究,并与其联合培养博士生。
现为:
1、中国载人空间站工程应用系统空间生命科学领域专家组成员
2、中国载人空间站空间应用系统国际评审专家组成员
3、《Advances in Bioscience and Biotechnology》杂志主编(2010-2012)
4、《World Journal of Stem Cells》杂志编委
5、《中国组织工程研究与临床康复》杂志干细胞学科首席专家
6、《寄生虫与医学昆虫学报》杂志编委。
7、美国《Journal of TransplanationTechnologies & Research》杂志编委
8、《中华细胞与干细胞杂志》杂志编委
9、《American Journal of Stem Cells》杂志资深编委
10、《Journal of Transplantation & Stem Cell Biology》杂志编委

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1、人骨髓间充质干细胞生物学;\r2、人造血干细胞生物学;\r3、空间医学(细胞生物学);\r4、组织工程与再生医学。\r
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selfintroduction
Dr. Jinfu Wang ProfessorInstiture of Cellular BiologyCollege of Life ScienceZhejiang UniversityHangzhou, 310058, P. R. China86- (O)86- (H and Fax)wjfu@zju.edu.cn EducationPH. D. Zhejiang Agricultural University 1991M.S. Zhejiang Agricultural University, 1984B.S. Zhejiang Agricultural University, 1981
Scientific Concurrent Postion
2014-: The member of Editorial Board for "Journal of Transplantation & Stem Cell Biology"
2013-: Senior Editor for Journal “American Journal of Stem Cells”
2010-2012: Editor-in-Chief forJournal “Advances in Bioscience and Biotechnology”
2011-: The member of Editorial Board for “Journal of TransplantationTechnologies&Research”
2011-: The member of Editorial Board for “Chinese Journal of Cell and Stem Cell”
2009-: The Member of Editorial Boardfor Journal “WorldJournal of Stem Cells”
2010-: The Chief Expert for Journal “Journal of Clinical Rehabilitative Tissue Engineering Research”
2006-: The Member of Editorial Board for Journal “Acta Parasitologica et Medica Entomologica Sinica”
Professional Experience1985-1988: Assistant Researcher, Institute of Plant Protection, Zhejiang Agricultural Academy1991-1997: Associate Researcher, Institute of Parasitology, Zhejiang Medical Academy1997-1999: Associate Professor, College of Life Sciences, Hangzhou University1999-: Professor, College of Life Sciences, Zhejiang University2002: Visiting Scholar, BMT Lab, University of Colorado Health Science Center2005: Visiting Scholar, Institution of Biochemistry and Molecular Biology, University of Southern Denmark
Research InterestsBiologies of human bone marrow mesenchymal stem cells (hMSCs) and human hematopoietic stem cells (hHSCs).Effects of gravity and microgravity on the in vivo differentiation and expension of hMSCs and hHSCs.
Tissue engineering based on hMSCs.Selected Publications1. Huang ZH, Wang JF. 2000. A novel estrogen-ER beta. Chinese Bulletin of Life Sciences, 12: 126-129.
2. Huang HF, Mershon JL, Wang JF. 2000. Sequencing and cloning of human estrogen-beta receptor cDNA in human granulosa. Natl Med J China, 80: 28-30.
3. Wang JF, Wang LJ, Harrintong J, McNiece IK. 2003. Effects of bone marrow-derived mesenchymal stem cell layer on expansion and differentiation of hematopoietic stem cells from cord blood. J Zhejiang Univer, 30: 93-97.
4. Wang JF, Qiu LY, Harrintong J, McNiece IK. 2003. Study of ex vivo expansion of mouse hematopoietic stem\/progenitor cells and the use of them for hematopoiesis reconstitution. Chinese Jouranl of Hematology, 24: 584-588.
5. Qiu LY, Wang JF. 2003. Advances of studies on mesenchymal stem cells. Chinese Journal of Biotechnology, 19: 136-140.
6. Zhang SZ, Wang W, Chen GM, Wang JF, Xiang Y. 2003. Cryomicroscope and its use in the observation of intracellular ice. Cellular Biology, 2003: 231-234.
7. Wang JF, Wu YF, Harrintong J, McNiece JK. 2004. Effects of expanded hematopoietic stem \/ progenitor cells on mouse hematopoietic recovery--rapid hematopoietic recovery, long term engraftment and endogenous recovery. J Zhejiang Univer, 38: 368-372.
8. Wang JF, Wu YF, Harrintong J, McNiece JK. 2004. Ex vivo expansions and transplantations of mouse bone marrow-derived hematopoietic stem\/progenitor cells. J Zhejiang Univer, 5: 157-163.
9. Huang ZH, Hua D, Li LH, Wang JF. 2004. Ex vivo pansion of cytokine-induced natural killer cells from tumpr patients for autologous therapy. J Microbiol Immunol, 2: 205-209.
10. Lai PP, Han CM, Jin HH, Wang JF. 2004. The isolation and culture of mesenchymal stem cells from human bone marrow and their biological properties. Zhejiang Medicine, 26: 328-330.
11. Huang ZH, Li LH, Hua D, Wang JF. 2004. Study on expansion of CD56+ cytotoxic lymphocytes from human umbilical cord blood. Acta Univer. Med. Nanjing (Natural Science), 24: 612-614.
12. Wang JF, Wang LJ, Xiang Y, Wu YF, Xie CG, Jia BB, Huang GP, Harrington J, MvNiece IK, 2004. Ex vivo expansion and transplantation of mouse bone marrow-derived hematopoietic stem\/progenitor cells supported by an adherent cell feeder layer from human umbilical cord blood. Stem Cell and Cellular Therapy, 2: 18-26.
13. Qiu LY, Wang JF, Shen D, Jin J. 2004. Expansion and chondrogenic induction of human bone marrow mesenchymal stem cells. J Zhejiang Univer, 31: 337-342.
14. Xiang Y, Wang JF. 2004. Effects of Chinese drugs on proliferation and differentiation of hematopoietic stem\/progenitor cells. Chinese J. Intergrated traditional Western Medicine, 24: 666-669.
15. Wang JF, Wang LJ, Wu YF, Xiang Y, Xie CG, Jia BB, Harrington J, McNiece. 2004. Mesenchymal stem cells in human umbilical cord blood as support for ex vivo expansion of CD34+ hematopoietic stem cells and for chondrogenic differentiation. Haematologica, 89: 837-843.
16. Zhang SZ, Wang W, Zhou XL, Chen GM, Hu JX, Wang JF, Xiang Y, Yin HB. 2004. Experimental study on osmotic properties of human cord blood stem cells. J Biomathematics, 19: 26-30.
17. Wang LJ, Zhang YP, Wang JF, Wu YF, Xiang Y, Xie CG, Jia BB, Harrington J, McNiece IK. 2005. Biological charateristics of mesenchymal stem cells in human umbilical cord blood and their supporting capacities in ex vivo expansion of CD34+ hematopoietic stem cells. Chin J Hematol, 26: 65-69.
18. Wang JF, Xiang Y, Xie CG, Jia BB. 2005. Experimental study of ex vivo expanded hematopoietic stem\/progenitor in the two step culture from human umbilical cord blood transplanted into NOD\/SCID mice. J Zhejiang Univer, 32: 448-451.
19. Wang LJ, Wang JF, Wu YF, Xiang Y, Xie CG, Jia BB, Yan JN, Zhu XF. 2005. Adherent cell layer from human umbilical cord blood and its support to ex vivo expansion of hematopoietic stem\/progenitor cells. J Zhejiang Univer, 32: 433-437.
20. Xie CG, Wang JF, Xiang Y, Qiu LY, Jia BB, Wang LJ, Wu YF, Wang GZ, Huang GP. 2005. Human bone marrow mesenchymal stem cells transduced with TPO\/FL genes as support for ex vivo expansion of hematopoietic stem\/progenitor cells from human cord blood. Mol Cell Life Sci, 62: 2495-2507.
21. Xie CG, Wang JF, Xiang Y, Qiu LY, Jia BB, Wang LJ, Wu YF, Wang GZ, Huang GP. 2006. Cocultivation of umbilical cord blood CD34+ cells with retro-transduced hMSCs leads to effective amplification of long-term culture-initiating cells. World J Gastroenetrol, 12: 393-402.
22. Xie CG, Jia BB, Xiang Y, Wang JF, et al. 2006. Support of hMSCs transducted with TPO\/FL genes to expansion of umbilical cord CD34+ cells in indirect co-culture. Cell and Tissue Res, 326: 101-110.
23. Xiang Y, Wang JF, Shen D, Zheng Q, Xie CG, Jia BB, Huang GP, Jin J. 2007. Ex vivo expansion and differentiation pluripotential of cryopreserved human bone marrow mesenchymal stem cells. International Journal of Cellular Biology, 31: 444-450.
24. Zheng Q, Huang GP, Yang JF, Wang JF, et al. 2007. Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways? Biological Chemistry, 388: 755-763.
25. Wang GZ, Huang GP, Yin GL, Zhou, G, Guo CJ, Xie CG, Jia BB, Wang JF. 2007. Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. Cellular Physiology and Biochemistry, 20: 205-212.
26. Huang GP, Pan ZJ, Jia BB, Zheng Q, Xie CG, Gu JH, McNiece IK, Wang JF. 2007. Ex vivo expansion and transplantation of hematopoietic stem\/progenitor cells supported by mesenchymal stem cells form human umbilical cord blood. Cell Transplantation, 16: 579-585.
27. Huang ZH, Li LH, Wang JF. 2007. Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions. Dig Dis Sci, 52: 2287-2291.
28. Pan ZJ, Yang JF, Guo CJ, Wang JF. 2008. Effects of hindlimb unloading on ex vivo growth and osteogenic\/adipogenic potentials of bone marrow-derived mesenchymal stem cells in rats. Stem Cells and Devel, 17: 795-804.
29. Huang GP, Pan ZJ, HUang JP, Wang JF, et al. 2008. Proteomic analysis of human bone marrow mesenchymal stem cells transduced with human telomerase reverse transcriptase gene during proliferation. Cell Prolif, 41: 625-644.
30. Huang GP, Zheng Q, Sun J, Wang JF. 2008. Stabilization of cellular properties and differentiation multipotential of human mesenchymal stem cells transduced with hTERT gene in a long-term culture. J Cell Biochem, 103: 1256-1269.
31. Zhao HG, Ma L, Gao CY, Wang JF. 2009. Fabrication and properties of injectable beta-tricalcium phosphate particles\/fibrin gel composite scaffolds for bone tissue engineering. Mater Sci Eng C, 29: 836-842.
32. Ma D, Chen HW, Shi DY, Wang JF. 2009. Preparation and characterization of thermo-responsive PDMS surface grafted with poly N-isopropylacrylamide by benzophenone-initiated photolymerization. J Colloid Sci, 332: 85-90.
33. Chen R, Lu SH, Tong QB, Lou D, Shi DY, Jia BB, Huang GP, Wang JF. 2009. Protective effect of DNA-mediated immunization with liposome-encapsulated GRA4 against infection of Toxoplasma gondii. J Zhejiang Univ Sci B, 10: 512-521.
34. Xu YL, Yu ML, Wu FB, Sun JG, Wood C, Hattori MA, Wang JF, Xi YM. 2009. Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells. J Exp Zool, 312B: 872-884.
35. Yang JF, Cao C, Wang W, Tong XM, Shi DY, Wu FB, Zheng Q, Guo CJ, Pan ZJ, Gao CY, Wang JF. 2010. Proliferation and osteogenesis of immortalized bone marrow-derived mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture. J Biomed Mater Res A, 92A: 817-829.
36. Shi DY, Ma D, Dong FQ, Zong C, Liu LY, Shen D, Yuan WJ, Tong XM, Chen HW, Wang JF. 2010. Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermo-responsive PDMS surfaces grafted with PNIPAAm. Biosci Rep, 30: 149-158.
37. Liu LY, Yuan WJ, Wang JF. 2010. Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress. Biomech Model Mechanobio, 9:659-670.
38. Zong C, Xue DT, Yuan WJ, Wang W, Shen D, Tong XM, Shi DY, Liu LY, Zheng Q, Gao CY, Wang JF. 2010. Reconstruction of rat calvarial defect with human mesenchymal stem cells and osteoblast-like cells in poly-lactic-co-glycolic acid scaffolds. Eur Cells Mater, 20: 109-120.
39. Shi DY, Meng R, Deng WL, Ding WC, Zheng Q, Yan WJ, Liu LY, Zong C, Shang P, Wang JF. 2010. Effects of microgravity modeled by large gradient high magnetic field on the osteogenic initation of human mesenchymal stem cells. Stem cell Rev Rep, 6: 567-578.
40. Meng R, Xu HY, Di SM, Shi DY, Qian AR, Wang JF, Shang P. 2011. Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. Acta Biochem Biophys Sin, 43: 133-142.
41. Guo CJ, Gao Y, Hou D, Shi DY, Tong XM, Shen D, Xi YM, Wang JF. 2011. Preclinical transplantation and safety of HS\/PCs expanded from human umbilical cord blood. World J Stem Cells, 3: 43-52.
42. Liu LY, Shao L, Li B, Zong C, Li JH, Zheng Q, Tong XM, Gao CY, Wang JF. 2011. Extracellular signal-reglated kinase 1\/2 activated by fluid shear stress promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through novel signaling pathways. Int J Biochem Cell Biol, 43: 1591-1601.
43. "Effects of Helicobacter Pylori and Non-Steroidal Anti-Inflammatory Drugs on Peptic Ulcer" in 《Petic Ulcer Disease》edited by Jianyuan Chai Published by InTechOpen, June 2011, pp. 29-38.
44. Wang JF, Zong C, Shi DY, Wang W, Shen D, Liu LY, Tong XM, Zheng Q, Gao CY. 2012. Hepatogenic engineering from human bone marrow mesenchymal stem cells in porous polylactic glycolic acidscaffolds under perfusionculture. J Tissue Eng Regen Med, 6: 29-39.
45. Liu LY, Yu B, Chen JR, Tang ZH, Zong C, Shen D, Zheng Q, Tong XM, Gao CY, Wang JF. 2012. Different effects of intermittent and continous fluid shear stresses on osteogenic differentiation of human mesenchymal stem cells. Biomech Model Mechanobiol, 11: 391-401.
46. Jia BB, Madsen L, Petersen RK, Techer N, Kopperud R, Mao T, Doskeland SO, Ailhaud G, Wang JF, Amri EZ, Kristiansen K. 2012. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PlosOne, 7: 34114-34124.
47. Tang ZH, Shi DY, Jia BB, Chen JR, Zong C, Shen D, Zheng Q, Wang JF, Tong XM. 2012. Exhange protein activated by cyclic adenosine monophosphate regulates the switch between adipogenesis and osteogenesis of human mesenchymal stem cells through increasing the activation of phosphatidylinositol 3-kinase. Int J Biochem Cell Biol, 44: 1106-1120.
48. Yuan WJ, Zong C, Huang YZ, Gao Y, Shi DY, Chen CS, Liu LY, Wang JF. 2012. Biological, immunological and regenerative characteristics of placenta-derived mesenchymal stem cells isolated using a time-gradient attachment method. Stem Cell Res, 9: 110-123.
49. Zong C, Qian XD, Tang ZH, Hu QH, Chen JR, Gao CY, Tang RK, Tong XM, Wang JF. 2013. Biocompatibility and bone-repairing effects: Comparison between porous poly-lactic-co-glycolic acid and nano-hydroxyapatite \/poly(lactic acid) scaffolds. J Biomed Nanotechnol, 9:1-14.
50. Chen J, Zhang C, Feng YD, Zong C, Chen JR, Tang ZH, Jia BB, Tong XM, Zheng Q, Wang JF. 2013. Studies on culture and osteogenic induction of human mesenchymal stem cells under CO2-independent conditions. Astrobiology, 13: 370-379.
51. Dai ZQ, Wu F, Chen J, Xu HJ, Wang HH, Guo FM, Tan YJ, Ding B, Wang JF, Wan YM, Li YH. 2013. Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity. PlosOne, 8: 63661-63670.
52. Liu LY, Zong C, Li B, Shen D, Tang ZH, Chen JR, Zheng Q, Tong XM, Gao CY, Wang JF. 2014. The interaction between belta1intergrins and ERK1\/2 osteogenic differentiation of human mesenchymal stem cells under fluid shear stress modeled by perfusion system. J Tissue Eng Regen Med, 8: 85-96.
53. Liu QW, Chen P, Wang JF. 2014. Molecular mechanisms and potentials for differentiating inner ear stem cells into seneory hair cells. Developmental Biology, 390: 93-101.
54. Qian XD, Zhang C, Chen GJ, Tang ZH, Liu QW, Chen JR, Tong XM, Wang JF. 2014. Effects of BMP-2 and FGF2 on the osteogenesis of bone marrow-derived mesenchymal stem cells in hindlimb-unloaded rats. Cell Biochem Biophys, 70:1127–1136.
55. Zhang C, Li L, Chen JL, Wang JF. 2015. Behavior of stem cells under outer-space microgravity and ground-based microgravity simulation. Cell Biology International, 2015: 1-10.
56. Liu QW, Chen JR, Gao XL, Ding J, Tang ZH, Zhang C, Chen JL, Li L, Chen P, Wang JF. 2015. Identification of stage-specific markers during differentiation of haircells from mouse inner ear stem cells or progenitor cells in vitro. International Journal of Biochemistry & Cell Biology, 60:99-111.
57. Liu QW, Shen Y, Chen JR, Ding J, Tang ZH, Zhang C, Chen JL, Li L, Chen P, Wang JF. 2016. Induction of functional hair-cell-like cells from mouse cochlear multipotent. Cells Stem Cells International, 2016: 1-14.
58. Chen JR, Tang ZH, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF. 2016. Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation. Cell Death and Differentiation, 23: 1347–1357.
59. Tang ZH, Chen JR, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF. 2016. Genetic correction of induced pluripotent stem cells from a deaf patient with MYO7A mutation results in morphologic and functional recovery of the derived hair cell-like cells. Stem Cells Translational Medicine, 5: 561-571.
60. Ding J, Tang ZH, Chen JR, Shi HS, Chen JL, Wang CC, Zhang C, Li L, Chen P, Wang JF. 2016. Induction of differentiation of human embryonic stem cells intofunctional hair-cell-like cells in the absence of stromal cellsJie International Journal of Biochemistry & Cell Biology, 81: 208-222.
61. Chen J, Li K, Pang QQ, Yang C, Zhang HY, Wu F, Cao HQ, Liu HJ, Wan YM, Xia WB, Wang JF, Dai ZQ, Li YH. 2016. Identification of suitable reference gene and biomarkers of serum miRNAs for osteoporosis. Scientific Reports, 6: 36347.
62. Chen LJ, Zhang CF, Chen L, Wang XJ, Xiang BY, Wu XX, Guo Y, Mou XZ, Yuan L, Chen B, Wang JF, Xiang C. 2017. Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators. Stem Cells Translational Medicine, 6: 272-284.
63. Zong C, Wang MC, Yang FC, Chen GJ, Chen JR, Tang ZH, Liu QW, Gao CY, Ma L, Wang JF. 2017. A novel therapy strategy for bile duct repair using tissue engineering technique: PCL\/PLGA bilayered scaffold with hMSCs. J Tissue Eng Regen Med, 11: 966–976
64. Zhang C, Hong FF, Wang CC, Li L, Chen JL, Liu F, Quan RF, Wang JF. 2017. TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1\/2 signaling pathway. Scientific Reports, 7: 10342.
65. Zong C, Wang MC, Yang FC, Chen GJ, Chen JR, Tang ZH, Liu QW, Gao CY, Ma L, Wang JF. 2017. A novel therapy strategy for bile duct repair using tissue engineering technique: PCL\/PLGA bilayered scaffold with hMSCs. J Tissue Eng Regen Med, 11: 966–976
66. Zhang C, Hong FF, Wang CC, Li L, Chen JL, Liu F, Quan RF, Wang JF. 2017. TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1\/2 signaling pathway. Scientific Reports, 7: 10342.

浙江大学生命科学学院教授、博士生导师,浙江大学细胞与遗传学研究所副所长。教学方面从事本科生《生物化学》、《高级生物化学》、《分子生物学》和《生命科学与技术导论》等课程以及研究生《细胞分子生物学》和《细胞发育生物学》等课程教学;科研方面从事造血干细胞和骨髓间充质干细胞扩增、分化及其相关分子机理研究,并开展基于人骨髓间充质干细胞的组织工程技术以及太空微重力环境影响干细胞分化与发育的分子机制研究。先后发表论文70多篇,其中31篇为SCI收录,2篇为EI收录。获省科技进步奖3项,申请技术发明专利13项,获授权8项。1999年获浙江省“151”跨世纪人才第一层次入选人员称号。2002年和2005年分别在美国科罗拉多医学科学中心和南丹麦大学从事合作研究,并与其联合培养博士生。
现为:1、《Advances in Bioscience and Biotechnology》杂志主编(2010-2012)
2、《World Journal of Stem Cells》杂志编委
3、《中国组织工程研究与临床康复》杂志干细胞学科首席专家
4、《寄生虫与医学昆虫学报》杂志编委。
5、美国《Journal of TransplanationTechnologies & Research》杂志编委
6、《中华细胞与干细胞杂志》杂志编委
7、《American Journal of Stem Cells》杂志资深编委
8、《Journal of Transplantation & Stem Cell Biology》杂志编委

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Dr. Jinfu Wang ProfessorInstiture of Cellular BiologyCollege of Life ScienceZhejiang UniversityHangzhou, 310058, P. R. China86- (O)86- (H and Fax)wjfu@zju.edu.cn EducationPH. D. Zhejiang Agricultural University 1991M.S. Zhejiang Agricultural University, 1984B.S. Zhejiang Agricultural University, 1981
Scientific Concurrent Postion
2014-: The member of Editorial Board for 'Journal of Transplantation & Stem Cell Biology'
2013-: Senior Editor for Journal “American Journal of Stem Cells”
2010-2012: Editor-in-Chief forJournal “Advances in Bioscience and Biotechnology”
2011-: The member of Editorial Board for “Journal of TransplantationTechnologies&Research”
2011-: The member of Editorial Board for “Chinese Journal of Cell and Stem Cell”
2009-: The Member of Editorial Boardfor Journal “WorldJournal of Stem Cells”
2010-: The Chief Expert for Journal “Journal of Clinical Rehabilitative Tissue Engineering Research”
2006-: The Member of Editorial Board for Journal “Acta Parasitologica et Medica Entomologica Sinica”
Professional Experience1985-1988: Assistant Researcher, Institute of Plant Protection, Zhejiang Agricultural Academy1991-1997: Associate Researcher, Institute of Parasitology, Zhejiang Medical Academy1997-1999: Associate Professor, College of Life Sciences, Hangzhou University1999-: Professor, College of Life Sciences, Zhejiang University2002: Visiting Scholar, BMT Lab, University of Colorado Health Science Center2005: Visiting Scholar, Institution of Biochemistry and Molecular Biology, University of Southern Denmark
Research InterestsBiologies of human bone marrow mesenchymal stem cells (hMSCs) and human hematopoietic stem cells (hHSCs).Effects of gravity and microgravity on the in vivo differentiation and expension of hMSCs and hHSCs.
Tissue engineering based on hMSCs.Selected Publications1. Huang ZH, Wang JF. 2000. A novel estrogen-ER beta. Chinese Bulletin of Life Sciences, 12: 126-129.
2. Huang HF, Mershon JL, Wang JF. 2000. Sequencing and cloning of human estrogen-beta receptor cDNA in human granulosa. Natl Med J China, 80: 28-30.
3. Wang JF, Wang LJ, Harrintong J, McNiece IK. 2003. Effects of bone marrow-derived mesenchymal stem cell layer on expansion and differentiation of hematopoietic stem cells from cord blood. J Zhejiang Univer, 30: 93-97.
4. Wang JF, Qiu LY, Harrintong J, McNiece IK. 2003. Study of ex vivo expansion of mouse hematopoietic stem\/progenitor cells and the use of them for hematopoiesis reconstitution. Chinese Jouranl of Hematology, 24: 584-588.
5. Qiu LY, Wang JF. 2003. Advances of studies on mesenchymal stem cells. Chinese Journal of Biotechnology, 19: 136-140.
6. Zhang SZ, Wang W, Chen GM, Wang JF, Xiang Y. 2003. Cryomicroscope and its use in the observation of intracellular ice. Cellular Biology, 2003: 231-234.
7. Wang JF, Wu YF, Harrintong J, McNiece JK. 2004. Effects of expanded hematopoietic stem \/ progenitor cells on mouse hematopoietic recovery--rapid hematopoietic recovery, long term engraftment and endogenous recovery. J Zhejiang Univer, 38: 368-372.
8. Wang JF, Wu YF, Harrintong J, McNiece JK. 2004. Ex vivo expansions and transplantations of mouse bone marrow-derived hematopoietic stem\/progenitor cells. J Zhejiang Univer, 5: 157-163.
9. Huang ZH, Hua D, Li LH, Wang JF. 2004. Ex vivo pansion of cytokine-induced natural killer cells from tumpr patients for autologous therapy. J Microbiol Immunol, 2: 205-209.
10. Lai PP, Han CM, Jin HH, Wang JF. 2004. The isolation and culture of mesenchymal stem cells from human bone marrow and their biological properties. Zhejiang Medicine, 26: 328-330.
11. Huang ZH, Li LH, Hua D, Wang JF. 2004. Study on expansion of CD56+ cytotoxic lymphocytes from human umbilical cord blood. Acta Univer. Med. Nanjing (Natural Science), 24: 612-614.
12. Wang JF, Wang LJ, Xiang Y, Wu YF, Xie CG, Jia BB, Huang GP, Harrington J, MvNiece IK, 2004. Ex vivo expansion and transplantation of mouse bone marrow-derived hematopoietic stem\/progenitor cells supported by an adherent cell feeder layer from human umbilical cord blood. Stem Cell and Cellular Therapy, 2: 18-26.
13. Qiu LY, Wang JF, Shen D, Jin J. 2004. Expansion and chondrogenic induction of human bone marrow mesenchymal stem cells. J Zhejiang Univer, 31: 337-342.
14. Xiang Y, Wang JF. 2004. Effects of Chinese drugs on proliferation and differentiation of hematopoietic stem\/progenitor cells. Chinese J. Intergrated traditional Western Medicine, 24: 666-669.
15. Wang JF, Wang LJ, Wu YF, Xiang Y, Xie CG, Jia BB, Harrington J, McNiece. 2004. Mesenchymal stem cells in human umbilical cord blood as support for ex vivo expansion of CD34+ hematopoietic stem cells and for chondrogenic differentiation. Haematologica, 89: 837-843.
16. Zhang SZ, Wang W, Zhou XL, Chen GM, Hu JX, Wang JF, Xiang Y, Yin HB. 2004. Experimental study on osmotic properties of human cord blood stem cells. J Biomathematics, 19: 26-30.
17. Wang LJ, Zhang YP, Wang JF, Wu YF, Xiang Y, Xie CG, Jia BB, Harrington J, McNiece IK. 2005. Biological charateristics of mesenchymal stem cells in human umbilical cord blood and their supporting capacities in ex vivo expansion of CD34+ hematopoietic stem cells. Chin J Hematol, 26: 65-69.
18. Wang JF, Xiang Y, Xie CG, Jia BB. 2005. Experimental study of ex vivo expanded hematopoietic stem\/progenitor in the two step culture from human umbilical cord blood transplanted into NOD\/SCID mice. J Zhejiang Univer, 32: 448-451.
19. Wang LJ, Wang JF, Wu YF, Xiang Y, Xie CG, Jia BB, Yan JN, Zhu XF. 2005. Adherent cell layer from human umbilical cord blood and its support to ex vivo expansion of hematopoietic stem\/progenitor cells. J Zhejiang Univer, 32: 433-437.
20. Xie CG, Wang JF, Xiang Y, Qiu LY, Jia BB, Wang LJ, Wu YF, Wang GZ, Huang GP. 2005. Human bone marrow mesenchymal stem cells transduced with TPO\/FL genes as support for ex vivo expansion of hematopoietic stem\/progenitor cells from human cord blood. Mol Cell Life Sci, 62: 2495-2507.
21. Xie CG, Wang JF, Xiang Y, Qiu LY, Jia BB, Wang LJ, Wu YF, Wang GZ, Huang GP. 2006. Cocultivation of umbilical cord blood CD34+ cells with retro-transduced hMSCs leads to effective amplification of long-term culture-initiating cells. World J Gastroenetrol, 12: 393-402.
22. Xie CG, Jia BB, Xiang Y, Wang JF, et al. 2006. Support of hMSCs transducted with TPO\/FL genes to expansion of umbilical cord CD34+ cells in indirect co-culture. Cell and Tissue Res, 326: 101-110.
23. Xiang Y, Wang JF, Shen D, Zheng Q, Xie CG, Jia BB, Huang GP, Jin J. 2007. Ex vivo expansion and differentiation pluripotential of cryopreserved human bone marrow mesenchymal stem cells. International Journal of Cellular Biology, 31: 444-450.
24. Zheng Q, Huang GP, Yang JF, Wang JF, et al. 2007. Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways? Biological Chemistry, 388: 755-763.
25. Wang GZ, Huang GP, Yin GL, Zhou, G, Guo CJ, Xie CG, Jia BB, Wang JF. 2007. Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. Cellular Physiology and Biochemistry, 20: 205-212.
26. Huang GP, Pan ZJ, Jia BB, Zheng Q, Xie CG, Gu JH, McNiece IK, Wang JF. 2007. Ex vivo expansion and transplantation of hematopoietic stem\/progenitor cells supported by mesenchymal stem cells form human umbilical cord blood. Cell Transplantation, 16: 579-585.
27. Huang ZH, Li LH, Wang JF. 2007. Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions. Dig Dis Sci, 52: 2287-2291.
28. Pan ZJ, Yang JF, Guo CJ, Wang JF. 2008. Effects of hindlimb unloading on ex vivo growth and osteogenic\/adipogenic potentials of bone marrow-derived mesenchymal stem cells in rats. Stem Cells and Devel, 17: 795-804.
29. Huang GP, Pan ZJ, HUang JP, Wang JF, et al. 2008. Proteomic analysis of human bone marrow mesenchymal stem cells transduced with human telomerase reverse transcriptase gene during proliferation. Cell Prolif, 41: 625-644.
30. Huang GP, Zheng Q, Sun J, Wang JF. 2008. Stabilization of cellular properties and differentiation multipotential of human mesenchymal stem cells transduced with hTERT gene in a long-term culture. J Cell Biochem, 103: 1256-1269.
31. Zhao HG, Ma L, Gao CY, Wang JF. 2009. Fabrication and properties of injectable beta-tricalcium phosphate particles\/fibrin gel composite scaffolds for bone tissue engineering. Mater Sci Eng C, 29: 836-842.
32. Ma D, Chen HW, Shi DY, Wang JF. 2009. Preparation and characterization of thermo-responsive PDMS surface grafted with poly N-isopropylacrylamide by benzophenone-initiated photolymerization. J Colloid Sci, 332: 85-90.
33. Chen R, Lu SH, Tong QB, Lou D, Shi DY, Jia BB, Huang GP, Wang JF. 2009. Protective effect of DNA-mediated immunization with liposome-encapsulated GRA4 against infection of Toxoplasma gondii. J Zhejiang Univ Sci B, 10: 512-521.
34. Xu YL, Yu ML, Wu FB, Sun JG, Wood C, Hattori MA, Wang JF, Xi YM. 2009. Effects of ectopic expression of human telomerase reverse transcriptase on immortalization of feather keratinocyte stem cells. J Exp Zool, 312B: 872-884.
35. Yang JF, Cao C, Wang W, Tong XM, Shi DY, Wu FB, Zheng Q, Guo CJ, Pan ZJ, Gao CY, Wang JF. 2010. Proliferation and osteogenesis of immortalized bone marrow-derived mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture. J Biomed Mater Res A, 92A: 817-829.
36. Shi DY, Ma D, Dong FQ, Zong C, Liu LY, Shen D, Yuan WJ, Tong XM, Chen HW, Wang JF. 2010. Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermo-responsive PDMS surfaces grafted with PNIPAAm. Biosci Rep, 30: 149-158.
37. Liu LY, Yuan WJ, Wang JF. 2010. Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress. Biomech Model Mechanobio, 9:659-670.
38. Zong C, Xue DT, Yuan WJ, Wang W, Shen D, Tong XM, Shi DY, Liu LY, Zheng Q, Gao CY, Wang JF. 2010. Reconstruction of rat calvarial defect with human mesenchymal stem cells and osteoblast-like cells in poly-lactic-co-glycolic acid scaffolds. Eur Cells Mater, 20: 109-120.
39. Shi DY, Meng R, Deng WL, Ding WC, Zheng Q, Yan WJ, Liu LY, Zong C, Shang P, Wang JF. 2010. Effects of microgravity modeled by large gradient high magnetic field on the osteogenic initation of human mesenchymal stem cells. Stem cell Rev Rep, 6: 567-578.
40. Meng R, Xu HY, Di SM, Shi DY, Qian AR, Wang JF, Shang P. 2011. Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features. Acta Biochem Biophys Sin, 43: 133-142.
41. Guo CJ, Gao Y, Hou D, Shi DY, Tong XM, Shen D, Xi YM, Wang JF. 2011. Preclinical transplantation and safety of HS\/PCs expanded from human umbilical cord blood. World J Stem Cells, 3: 43-52.
42. Liu LY, Shao L, Li B, Zong C, Li JH, Zheng Q, Tong XM, Gao CY, Wang JF. 2011. Extracellular signal-reglated kinase 1\/2 activated by fluid shear stress promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through novel signaling pathways. Int J Biochem Cell Biol, 43: 1591-1601.
43. 'Effects of Helicobacter Pylori and Non-Steroidal Anti-Inflammatory Drugs on Peptic Ulcer' in 《Petic Ulcer Disease》edited by Jianyuan Chai Published by InTechOpen, June 2011, pp. 29-38.
44. Wang JF, Zong C, Shi DY, Wang W, Shen D, Liu LY, Tong XM, Zheng Q, Gao CY. 2012. Hepatogenic engineering from human bone marrow mesenchymal stem cells in porous polylactic glycolic acidscaffolds under perfusionculture. J Tissue Eng Regen Med, 6: 29-39.
45. Liu LY, Yu B, Chen JR, Tang ZH, Zong C, Shen D, Zheng Q, Tong XM, Gao CY, Wang JF. 2012. Different effects of intermittent and continous fluid shear stresses on osteogenic differentiation of human mesenchymal stem cells. Biomech Model Mechanobiol, 11: 391-401.
46. Jia BB, Madsen L, Petersen RK, Techer N, Kopperud R, Mao T, Doskeland SO, Ailhaud G, Wang JF, Amri EZ, Kristiansen K. 2012. Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells. PlosOne, 7: 34114-34124.
47. Tang ZH, Shi DY, Jia BB, Chen JR, Zong C, Shen D, Zheng Q, Wang JF, Tong XM. 2012. Exhange protein activated by cyclic adenosine monophosphate regulates the switch between adipogenesis and osteogenesis of human mesenchymal stem cells through increasing the activation of phosphatidylinositol 3-kinase. Int J Biochem Cell Biol, 44: 1106-1120.
48. Yuan WJ, Zong C, Huang YZ, Gao Y, Shi DY, Chen CS, Liu LY, Wang JF. 2012. Biological, immunological and regenerative characteristics of placenta-derived mesenchymal stem cells isolated using a time-gradient attachment method. Stem Cell Res, 9: 110-123.
49. Zong C, Qian XD, Tang ZH, Hu QH, Chen JR, Gao CY, Tang RK, Tong XM, Wang JF. 2013. Biocompatibility and bone-repairing effects: Comparison between porous poly-lactic-co-glycolic acid and nano-hydroxyapatite \/poly(lactic acid) scaffolds. J Biomed Nanotechnol, 9:1-14.
50. Chen J, Zhang C, Feng YD, Zong C, Chen JR, Tang ZH, Jia BB, Tong XM, Zheng Q, Wang JF. 2013. Studies on culture and osteogenic induction of human mesenchymal stem cells under CO2-independent conditions. Astrobiology, 13: 370-379.
51. Dai ZQ, Wu F, Chen J, Xu HJ, Wang HH, Guo FM, Tan YJ, Ding B, Wang JF, Wan YM, Li YH. 2013. Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity. PlosOne, 8: 63661-63670.
52. Liu LY, Zong C, Li B, Shen D, Tang ZH, Chen JR, Zheng Q, Tong XM, Gao CY, Wang JF. 2014. The interaction between belta1intergrins and ERK1\/2 osteogenic differentiation of human mesenchymal stem cells under fluid shear stress modeled by perfusion system. J Tissue Eng Regen Med, 8: 85-96.
53. Liu QW, Chen P, Wang JF. 2014. Molecular mechanisms and potentials for differentiating inner ear stem cells into seneory hair cells. Developmental Biology, 390: 93-101.

54. Qian XD, Zhang C, Chen GJ, Tang ZH, Liu QW, Chen JR, Tong XM, Wang JF. 2014. Effects of BMP-2 and FGF2 on the osteogenesis of bone marrow-derived mesenchymal stem cells in hindlimb-unloaded rats. Cell Biochem Biophys, 70:1127–1136.
55. Zhang C, Li L, Chen JL, Wang JF. 2015. Behavior of stem cells under outer-space microgravity and ground-based microgravity simulation. Cell Biology International, 2015: 1-10.
56. Liu QW, Chen JR, Gao XL, Ding J, Tang ZH, Zhang C, Chen JL, Li L, Chen P, Wang JF. 2015. Identification of stage-specific markers during differentiation of haircells from mouse inner ear stem cells or progenitor cells in vitro. International Journal of Biochemistry & Cell Biology, 60:99-111.
57. Liu QW, Shen Y, Chen JR, Ding J, Tang ZH, Zhang C, Chen JL, Li L, Chen P, Wang JF. 2016. Induction of functional hair-cell-like cells from mouse cochlear multipotent. Cells Stem Cells International, 2016: 1-14.
58. Chen JR, Tang ZH, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF. 2016. Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation. Cell Death and Differentiation, 23: 1347–1357.
59. Tang ZH, Chen JR, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF. 2016. Genetic correction of induced pluripotent stem cells from a deaf patient with MYO7A mutation results in morphologic and functional recovery of the derived hair cell-like cells. Stem Cells Translational Medicine, 5: 561-571.
60. Ding J, Tang ZH, Chen JR, Shi HS, Chen JL, Wang CC, Zhang C, Li L, Chen P, Wang JF. 2016. Induction of differentiation of human embryonic stem cells intofunctional hair-cell-like cells in the absence of stromal cellsJie International Journal of Biochemistry & Cell Biology, 81: 208-222.
61. Chen J, Li K, Pang QQ, Yang C, Zhang HY, Wu F, Cao HQ, Liu HJ, Wan YM, Xia WB, Wang JF, Dai ZQ, Li YH. 2016. Identification of suitable reference gene and biomarkers of serum miRNAs for osteoporosis. Scientific Reports, 6: 36347.
62. Chen LJ, Zhang CF, Chen L, Wang XJ, Xiang BY, Wu XX, Guo Y, Mou XZ, Yuan L, Chen B, Wang JF, Xiang C. 2017. Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators. Stem Cells Translational Medicine, 6: 272-284.
63. Zong C, Wang MC, Yang FC, Chen GJ, Chen JR, Tang ZH, Liu QW, Gao CY, Ma L, Wang JF. 2017. A novel therapy strategy for bile duct repair using tissue engineering technique: PCL\/PLGA bilayered scaffold with hMSCs. J Tissue Eng Regen Med, 11: 966–976
64. Zhang C, Hong FF, Wang CC, Li L, Chen JL, Liu F, Quan RF, Wang JF. 2017. TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1\/2 signaling pathway. Scientific Reports, 7: 10342.
65. Zong C, Wang MC, Yang FC, Chen GJ, Chen JR, Tang ZH, Liu QW, Gao CY, Ma L, Wang JF. 2017. A novel therapy strategy for bile duct repair using tissue engineering technique: PCL\/PLGA bilayered scaffold with hMSCs. J Tissue Eng Regen Med, 11: 966–976
66. Zhang C, Hong FF, Wang CC, Li L, Chen JL, Liu F, Quan RF, Wang JF. 2017. TRIB3 inhibits proliferation and promotes osteogenesis in hBMSCs by regulating the ERK1\/2 signaling pathway. Scientific Reports, 7: 10342.

浙江大学生命科学学院教授、博士生导师,浙江大学细胞与遗传学研究所副所长。教学方面从事本科生《生物化学》、《高级生物化学》、《分子生物学》和《生命科学与技术导论》等课程以及研究生《细胞分子生物学》和《细胞发育生物学》等课程教学;科研方面从事造血干细胞和骨髓间充质干细胞扩增、分化及其相关分子机理研究,并开展基于人骨髓间充质干细胞的组织工程技术以及太空微重力环境影响干细胞分化与发育的分子机制研究。先后发表论文70多篇,其中31篇为SCI收录,2篇为EI收录。获国家科技成果二等奖1项、浙江省科技成果一等奖1项、二等奖2项、三等奖3项,申请技术发明专利13项,获授权8项。1999年获浙江省“151”跨世纪人才第一层次入选人员称号。2002年和2005年分别在美国科罗拉多医学科学中心和南丹麦大学从事合作研究,并与其联合培养博士生。
现为:
1、中国载人空间站工程应用系统空间生命科学领域专家组成员
2、中国载人空间站空间应用系统国际评审专家组成员
3、《Advances in Bioscience and Biotechnology》杂志主编(2010-2012)
4、《World Journal of Stem Cells》杂志编委
5、《中国组织工程研究与临床康复》杂志干细胞学科首席专家
6、《寄生虫与医学昆虫学报》杂志编委。
7、美国《Journal of TransplanationTechnologies & Research》杂志编委
8、《中华细胞与干细胞杂志》杂志编委
9、《American Journal of Stem Cells》杂志资深编委
10、《Journal of Transplantation & Stem Cell Biology》杂志编委

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