酶工程实验室 Chiralzyme
summary
于洪巍 博士, 教授，博导
浙江大学化学工程与生物工程学院生物工程研究所，杭州，邮编310027
Prof. Yu Hongwei
Mailing address: Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China, 310027.
Office: Room 408, AreaB, Building West-7, Xixi Campus, Zhejiang University
E-mail: yuhongwei@zju.edu.cn
Professor Yu obtained his Bachelor degree in 1995 and Master degree in 1998 in Chemical Engineering from Tsinghua University, China and his Ph.D in 2002 in Chemical Engineering from National University of Singapore, Singapore，supervised by Prof. Ching Chi Bun. After working in National University of Singapore, Nanyang Technological University and California Institute of Technology, he went back China and took the professorship in Zhejiang University in 2007. Professor Yu had studied chiral drug separation technologies for many years, including chromatographic technologies (simulated moving bed) and enzymatic resolution of racemic mixture. His research interests are now focused on improving enzyme activity and enantioselectivity by genetic engineering to produce chiral compounds. In recent years, his research interests are expanded to biosynthesis of natural products by metabolic engineering.
教育背景:
1999年1月— 2002年1月: 在新加坡国立大学化学与环境工程系攻读博士学位，并于2002年10月获工学博士学位。
1995年9月—1998年7月: 在清华大学核能技术研究院学习，获工学硕士学位。
1990年9月—1995年7月: 在清华大学化学工程系学习，获工学学士学位。
工作经历:
1998年7月—1998年12月：清华紫光英力公司，研发工程师.
2002年2月— 2005年1月：新加坡国立大学化学及过程工程中心，博士后研究员
2005年2月—2007年6月：新加坡南洋理工大学化学与生物分子工程系，博士后研究员。其间2005年9月—2006年3月，在美国加州理工学院作博士后, 进行酶的定向进化研究.
2007年7月—：浙江大学化学工程与生物工程学院，教授，博导
代表性文章:
[1] Lv, Xiaomei; Wang, Fan; Zhou, Pingping; et al.
Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae; Nature Communications Volume: 7 Published: SEP 2016.
[2] Wang, Fan; Lv, Xiaomei; Xei, Wenping; et al.Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae; Metabolic Engineering Volume: 39 Pages: 257-266 Published: JAN 2017
[3]]Xie, Wenping; Lv, Xiaomei; Ye, Lidan; et al.Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering; Metabolic Engineering Volume: 30 Pages: 69-78 Published: JUL 2015.
[4]Li, Aipeng; Ye, Lidan; Yang, Xiaohong; et al.Structure-guided stereoselectivity inversion of a short-chain dehydrogenase\/reductase towards halogenated acetophenones; Chemical Communications Volume: 52 Issue: 37 Pages: 6284-6287 Published: 2016.
[5]Guo, Fei; Franzen, Stefan; Ye, Lidan; et al.Controlling Enantioselectivity of Esterase in Asymmetric Hydrolysis of Aryl Prochiral Diesters by Introducing Aromatic Interactions; Biotechnology and Bioengineering Volume: 111 Issue: 9 Pages: 1729-1739 Published: SEP 2014
工作研究领域：
酶定向进化及理性设计
酶催化手性药物拆分及合成的研究
代谢工程与合成生物学
Research Interests:
1) Enzymatic Directed Evolution and Rational Design;
2) Enzyme-catalyzed Resolution and Synthesis of Chiral Drugs;
3) Metabolic Engineering and Synthetic Biology
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\r于洪巍 博士, 教授，博导
\r
\r浙江大学化学工程与生物工程学院生物工程研究所，杭州，邮编310027
\r
\rProf. Yu Hongwei
\r
\rMailing address: Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China, 310027.
\rOffice: Room 408, AreaB, Building West-7, Xixi Campus, Zhejiang University
\rE-mail: yuhongwei@zju.edu.cn
\r
\r Professor Yu obtained his Bachelor degree in 1995 and Master degree in 1998 in Chemical Engineering from Tsinghua University, China and his Ph.D in 2002 in Chemical Engineering from National University of Singapore, Singapore，supervised by Prof. Ching Chi Bun. After working in National University of Singapore, Nanyang Technological University and California Institute of Technology, he went back China and took the professorship in Zhejiang University in 2007. Professor Yu had studied chiral drug separation technologies for many years, including chromatographic technologies (simulated moving bed) and enzymatic resolution of racemic mixture. His research interests are now focused on improving enzyme activity and enantioselectivity by genetic engineering to produce chiral compounds. In recent years, his research interests are expanded to biosynthesis of natural products by metabolic engineering.
\r
\r教育背景:
\r
\r1999年1月— 2002年1月: 在新加坡国立大学化学与环境工程系攻读博士学位，并于2002年10月获工学博士学位。
\r1995年9月—1998年7月: 在清华大学核能技术研究院学习，获工学硕士学位。
\r1990年9月—1995年7月: 在清华大学化学工程系学习，获工学学士学位。
\r
\r工作经历:
\r
\r1998年7月—1998年12月：清华紫光英力公司，研发工程师.
\r2002年2月— 2005年1月：新加坡国立大学化学及过程工程中心，博士后研究员
\r2005年2月—2007年6月：新加坡南洋理工大学化学与生物分子工程系，博士后研究员。其间2005年9月—2006年3月，在美国加州理工学院作访问****, 进行酶的定向进化研究.
\r2007年7月—：浙江大学化学工程与生物工程学院，教授，博导
\r
\r代表性文章:
\r[1] Lv, Xiaomei; Wang, Fan; Zhou, Pingping; et al.
\rDual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae; Nature Communications Volume: 7 Published: SEP 2016.
\r[2] Wang, Fan; Lv, Xiaomei; Xei, Wenping; et al.Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae; Metabolic Engineering Volume: 39 Pages: 257-266 Published: JAN 2017
\r[3]]Xie, Wenping; Lv, Xiaomei; Ye, Lidan; et al.Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering; Metabolic Engineering Volume: 30 Pages: 69-78 Published: JUL 2015.
\r[4]Li, Aipeng; Ye, Lidan; Yang, Xiaohong; et al.Structure-guided stereoselectivity inversion of a short-chain dehydrogenase\/reductase towards halogenated acetophenones; Chemical Communications Volume: 52 Issue: 37 Pages: 6284-6287 Published: 2016.
\r[5]Guo, Fei; Franzen, Stefan; Ye, Lidan; et al.Controlling Enantioselectivity of Esterase in Asymmetric Hydrolysis of Aryl Prochiral Diesters by Introducing Aromatic Interactions; Biotechnology and Bioengineering Volume: 111 Issue: 9 Pages: 1729-1739 Published: SEP 2014
\r
\r
\r
\r
\r
\r
\r工作研究领域：
\r
\r
\r酶定向进化及理性设计
\r酶催化手性药物拆分及合成的研究
\r代谢工程与合成生物学
\r
\r
\rResearch Interests:
\r
\r1) Enzymatic Directed Evolution and Rational Design;
\r2) Enzyme-catalyzed Resolution and Synthesis of Chiral Drugs;
\r3) Metabolic Engineering and Synthetic Biology
\r
url
telephone
yuhongwei@zju.edu.cn
address
西溪校区化学楼二区408
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2021-01-24 23:02:14
content
于洪巍 博士, 教授，博导
浙江大学化学工程与生物工程学院生物工程研究所，杭州，邮编310027
Prof. Yu Hongwei
Mailing address: Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, P.R. China, 310027.
Office: Room 408, AreaB, Building West-7, Xixi Campus, Zhejiang University
E-mail: yuhongwei@zju.edu.cn
Professor Yu obtained his Bachelor degree in 1995 and Master degree in 1998 in Chemical Engineering from Tsinghua University, China and his Ph.D in 2002 in Chemical Engineering from National University of Singapore, Singapore，supervised by Prof. Ching Chi Bun. After working in National University of Singapore, Nanyang Technological University and California Institute of Technology, he went back China and took the professorship in Zhejiang University in 2007. Professor Yu had studied chiral drug separation technologies for many years, including chromatographic technologies (simulated moving bed) and enzymatic resolution of racemic mixture. His research interests are now focused on improving enzyme activity and enantioselectivity by genetic engineering to produce chiral compounds. In recent years, his research interests are expanded to biosynthesis of natural products by metabolic engineering.
教育背景:
1999年1月— 2002年1月: 在新加坡国立大学化学与环境工程系攻读博士学位，并于2002年10月获工学博士学位。
1995年9月—1998年7月: 在清华大学核能技术研究院学习，获工学硕士学位。
1990年9月—1995年7月: 在清华大学化学工程系学习，获工学学士学位。
工作经历:
1998年7月—1998年12月：清华紫光英力公司，研发工程师.
2002年2月— 2005年1月：新加坡国立大学化学及过程工程中心，博士后研究员
2005年2月—2007年6月：新加坡南洋理工大学化学与生物分子工程系，博士后研究员。其间2005年9月—2006年3月，在美国加州理工学院作博士后, 进行酶的定向进化研究.
2007年7月—：浙江大学化学工程与生物工程学院，教授，博导
代表性文章:
[1] Lv, Xiaomei; Wang, Fan; Zhou, Pingping; et al.
Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae; Nature Communications Volume: 7 Published: SEP 2016.
[2] Wang, Fan; Lv, Xiaomei; Xei, Wenping; et al.Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae; Metabolic Engineering Volume: 39 Pages: 257-266 Published: JAN 2017
[3]]Xie, Wenping; Lv, Xiaomei; Ye, Lidan; et al.Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering; Metabolic Engineering Volume: 30 Pages: 69-78 Published: JUL 2015.
[4]Li, Aipeng; Ye, Lidan; Yang, Xiaohong; et al.Structure-guided stereoselectivity inversion of a short-chain dehydrogenase\/reductase towards halogenated acetophenones; Chemical Communications Volume: 52 Issue: 37 Pages: 6284-6287 Published: 2016.
[5]Guo, Fei; Franzen, Stefan; Ye, Lidan; et al.Controlling Enantioselectivity of Esterase in Asymmetric Hydrolysis of Aryl Prochiral Diesters by Introducing Aromatic Interactions; Biotechnology and Bioengineering Volume: 111 Issue: 9 Pages: 1729-1739 Published: SEP 2014
工作研究领域：
酶定向进化及理性设计
酶催化手性药物拆分及合成的研究
代谢工程与合成生物学
Research Interests:
1) Enzymatic Directed Evolution and Rational Design;
2) Enzyme-catalyzed Resolution and Synthesis of Chiral Drugs;
3) Metabolic Engineering and Synthetic Biology
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