基本资料
丰慧，博士，青年教授，硕士生导师。2009.6月南京大学化学化工学院化学专业获理学博士学位。2009.8起在浙江师范大学应用化学学科开展教学工作和相关科研工作。目前从事于光致发光材料的合成、性能调控及生物传感应用研究，以及基于小分子有机化合物的分子开关的设计与合成。目前主持国家自然科学基金面上项目一项和浙江省基金项目一项，主持完成国家自然科学基金青年基金一项和浙江省自然科学基金一项，参与两项国家自然科学基金面上项目和一项浙江省自然科学基金，参与完成横向项目一项；已在ChemComm、Anal. Chem.、Biosens. Bioelectron.、Chem. Eur. J.、Nanoscale、J. Mater. Chem.、SNB、ACS Applied Mater. Interface等国际著名学术期刊上发表六十余篇论文; 高被引论文有3篇，总引用次数超过1300次，被邀为JACS、Anal. Chem.、Biosens. Bioelectron.、SNB、Nanoscale、ACA、Talanta、Carbon等刊物的审稿人。指导研究生获耿儿奖学金、校级优秀研究生学位论文等。曾获2017年度浙江省自然科学奖三等奖。
主要研究方向
1. 新型发光材料的合成、性能调控及其在生物传感中的应用，包括碳量子点、金属纳米簇等发光纳米材料的可控制备，有机室温磷光材料的设计合成及应用，将其应用于重要疾病标志物等的生物传感与生物成像。
2. 基于有机小分子化合物的分子开关的设计、合成及分析检测应用，着重研究基于聚集诱导发光体系的磷光分子开关的设计与构建，并将其用于酪氨酸酶、硝基还原酶等氧化还原酶活性定量检测方法的建立，探索小分子光学探针在细胞和生物体内实时荧光示踪功能
科研项目
(1) 聚集诱导发光的金属纳米簇的可控制备、机制探讨和生物传感应用国家自然科学基金面上项目2018-2021 主持
(2) 基于光诱导转移机制的可控纳米探针的构建及应用浙江省自然基金项目2017-2019 主持
(3) 基于碳基纳米材料和荧光信号放大策略的多功能纳米传感器的设计、构建及应用国家自然科学基金青年科学基金2015-2017主持
(4) 碳量子点/氧化石墨烯荧光检测平台的构建及其对生物标记物DNA分子的检测浙江省基金项目2013-2015主持
(5) 基于碳纳米管和碳量子点的纳米靶向药物输送体系的构建及生物学评价浙江省自然科学基金 2013-2016 参与
(6) 采用密度泛函理论研究钙在多聚铝团簇形成中的作用高露洁公司 横向项目2012-2013 参与

代表学术论文
(1) Rational design of reversibly photochromic molecules with aggregation-induced emission by introducing photoactive thienyl and benzothienyl groups. Shasha Zhou, Sidan Guo, Weidong Liu, Qiaoying Yang, Huili Sun, Riqing Ding, Zhaosheng Qian and Hui Feng*J. Mater. Chem. C, 2020, https://doi.org/10.1039/D0TC02297G. (Cover Paper)
(2) Photochromism and Fluorescence Switch of Furan-Containing Tetraarylethene Luminogens with Aggregation-Induced Emission for Photocontrolled Interface-Involved Applications. Sidan Guo, Shasha Zhou, Jiajing Chen, Ping Guo, Riqing Ding, Huili Sun, Hui Feng, Qian, Zhaosheng. ACS Applied Materials &Interfaces 2020, DOI:10.1021/acsami.0c12603.
(3) Clustering-Triggered Ultralong Room-Temperature Phosphorescence of Organic Crystals through Halogen-Mediated Molecular Assembly. Huili Sun, Riqing Ding, Shanling Lv, Shasha Zhou, Sidan Guo, Zhaosheng Qian, Hui Feng*J. Phys. Chem. Lett.,2020,11, 4962-4969.
(4) Photophysical Switching between Aggregation-Induced Phosphorescence and Dual-State Emission by Isomeric Substitution. Wenbin, Xi, Junru Yu, Mengru Wei, Qianqian Qiu, Pengfei Xu, Zhaosheng Qian, Hui Feng*Chem. Eur. J. 2020, 26, 3733-3737.
(5) Guilin Chen, Sidan Guo, Hui Feng* and Zhaosheng Qian. Anion-regulated transient and persistent phosphorescence and size-dependent ultralong afterglow of organic ionic crystals. J. Mater. Chem. C, 2019, 7, 14535--14542. (Cover Paper)
(6) Pengfei Xu, Qianqian Qiu, Xinru Ye, Mengru Wei,Wenbin Xi, Hui Feng, Zhaosheng Qian, Halogenated tetraphenylethene with enhanced aggregation-induced emission: an anomalous anti-heavy-atom effect and self-reversible mechanochromism.Chem. Commun.,2019，55，14938-14941.
(7) Qianqian Qiu, Pengfei Xu, Yanjun Zhu, Junru Yu, Mengru Wei, Wenbin Xi, Hui Feng, Jianrong Chen, and Zhaosheng Qian. Rational Design of Dual-State Emission Luminogens with Solvatochromism by Combining a Partially Shared Donor–Acceptor Pattern and Twisted Structures. Chem. Eur. J. 2019，25，15983. (Cover Paper)
(8) Guilin Chen, Zaicai Zhou, Hui Feng, Chenyan Zhang, Yifan Wang, Zhaosheng Qian* and Jianwei Pan. An aggregation-induced phosphorescence probe for calcium ion-specific detection and live-cell imaging in Arabidopsis thaliana. Chem. Commun., 2019, 55, 4841--4844.
(9) Guilin Chen,^?Hui Feng,^?Wenbin Xi, Jing Xu, Saifei Pan and Zhaosheng Qian. Thiol–ene click reaction-induced fluorescence enhancement by altering the radiative rate for assaying butyrylcholinesterase activity. Analyst, 2019, 144, 559–566.
(10) Guilin Chen, Jin Zhou, Hui Feng, Feifei Feng, Pengfei Xu, Saifei Pan, Jing Xu,Zhaosheng Qian.* Simple and efficient phosphorescent probe for iodide-specific detection based on crystallization-induced phosphorescence of organic ionic crystals. J. Mater. Chem. C,2019, 7,43 - 47.
(11) Pengfei Xu, Zhiyi Bao, Chenyi Yu, Qianqian Qiu, MengruWei, Wenbin Xi, Zhaosheng Qian, Hui Feng,* A water-soluble molecular probe with aggregation-induced emission for discriminative detection of Al³⁺and Pb²⁺and imaging in seedling root of Arabidopsis. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2019,223, 117335.
(12) Guilin Chen, Jin Zhou, Hui Feng, Feifei Feng, Pengfei Xu, Saifei Pan, Jing Xu,Zhaosheng Qian.* Simple and efficient phosphorescent probe for iodide-specific detection based on crystallization-induced phosphorescence of organic ionic crystals. J. Mater. Chem. C,2019, 7,43 - 47.
(13) Hang Ao, Hui Feng, Saifei Pan, Zhiyi Bao, Zhenhui Li, Jianrong Chen,Zhaosheng Qian.*Synthesis and functionalization of stable and bright copper nanoclusters by in situ gereration of silica shells for bioimaging and biosensing. ACS Appl. Nano Mater.,2018, 1,5673 - 5681.
(14) Guilin Chen, Hui Feng, Feifei Feng, Pengfei Xu, Jing Xu, Saifei Pan,Zhaosheng Qian.*Photophysical tuning of organic ionic crystals from ultralong afterglow to highly efficient phosphorescence by variation of halides.J. Phys. Chem. Lett.,2018, 9,6305 - 6311.
(15) Jing Xu, Hui Feng, Hao Teng, Guilin Chen, Saifei Pan, Jianrong Chen,Zhaosheng Qian.*Reversible switching between phosphorescence and fluorescence in a unimolecular system controlled by external stimuli.Chem. Eur. J.,2018, 24,12773 - 12778.
(16) Saifei Pan, Zhentian Chen, Xulian Zheng, Donghui Wu, Guilin Chen, Jing Xu, Hui Feng,Zhaosheng Qian.*Ultralong room-temperature phosphorescence from supramolcular behavior via intermolecular electronic coupling in pure organic crystals.J. Phys. Chem. Lett.,2018, 9, 3939 - 3945.
(17) Hang Ao, Hui Feng, Keqing Li, Meizhi Zhao,Zhaosheng Qian,* Jianrong Chen*. Coordinate bonding-induced emission of gold glutathione complex for sensitive detection of aluminum species.Sens. Actuat. B-Chem,2018, 272, 1 - 7.
(18) Saifei Pan, Weidong Liu, Jiantao Tang, Yingjie Yang, Hui Feng,Zhaosheng Qian*, Jin Zhou*. Hydrophobicity-guided self-assembled particles of silver nanoclusters with aggregation-induced emission and their use in sensing and bioimaging.J. Mater. Chem. B,2018, 6, 3927 - 3933.
(19) Hui Feng,Zhaosheng Qian*. Functional Carbon Quantum Dots: A Versatile Platform for Chemosensing and Biosensing.Chem. Rec.,2018, 18, 491 - 505. (Invited Review)
(20) Guilin Chen, Hui Feng, Xiaogan Jiang, Jing Xu, Saifei Pan,Zhaosheng Qian*. Redox-controlled fluorescent nanoswitch based on reversible disulfide and its application in butyrylcholinesterase activity assay.Anal.Chem.,2018, 90, 1643-1651.
(21) Jing Xu, Fengqi Zhou, Luxi Chen, Guilin Chen, Saifei Pan, Zhaosheng Qian, Hui Feng.* Thiol-triggered disaggregation-induced emission controlled by competitive coordination for acetylcholinesterase monitoring and inhibitor screening. Sens. Actuat. B-Chem, 2018, 255, 22-28.
(22) Meizhi Zhao, Hui Feng, Xiaoxiao Zhang, Hang Ao,Zhaosheng Qian*. Bonding-Induced Emission of Silyl-Protected Copper Nanoclusters for Luminescence Turn-on Detection of Trace Water in Organic Solvents.Analyst,2017, 142, 4613-4617. (Cover Paper)
(23) Hang Ao, Hui Feng, Mengting Zhao, Meizhi Zhao, Jianrong Chen, Zhaosheng Qian.* Redox-triggered bonding-induced emission of thiol-functionalized gold nanoclusters for luminescence turn-on detection of molecular oxygen. ACS Sens., 2017, 2, 1692-1699.
(24) Meizhi Zhao, Zhaosheng Qian(Coauthors), Mengting Zhong, Zhentian Chen, Hang Ao, Hui Feng.* Fabrication of stable and luminescent copper nanocluster-based AIE particles and their application in β-galactosidase activity assay. ACS Appl. Mater. Interfaces, 2017, 9, 32887-32895.
(25) Meizhi Zhao, Hui Feng, Jiaonan Han, Hang Ao, Zhaosheng Qian*. Multi-stimuli responsive copper nanoclusters with bright red luminescence for quantifying acid phosphatase via redox-controlled luminescence switch.Anal Chim. Acta,2017, 984, 202-210.
(26) Yuanyuan Huang, Hui Feng, Weidong Liu, Shasha Zhang, Cong Tang, Jianrong Chen, Zhaosheng Qian,* Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for beta-galactosidase activity monitoring, J. Mater. Chem. B, 2017, 5, 5120-5127.
(27) Cong Tang, Hui Feng, Yuanyuan Huang,Zhaosheng Qian*. Reversible Luminescent Nanoswitches Based on Aggregation-Induced Emission Enhancement of Silver nanoclusters for Luminescence Turn-on Assay of Inorganic Pyrophosphatase Activity.Anal. Chem.2017, 89, 4994-5002.
(28) Qian Sun, Siying Fang, Yafen Fang, Zhaosheng Qian, Hui Feng*. Fluorometric Detection of Cholestrol Based on beta-Cyclodextrin Functionalized Carbon Quantum Dots via Competitive Host-Guest Recognition.Talanta, 2017,167, 513-519.
(29) Ao Hang, Hui Feng, Xiaolu Huang, Meizhi Zhao, Zhaosheng Qian*. A Reversible Fluorescence Nanoswitch Based on Dynamic Covalent B-O Bonds Using Functional Carbon Quantum Dots and Its Application for α-Glucosidase Activity Monitoring.J. Mater. Chem.C,2017, 5, 2826-2832.
(30) Cong Tang, Jin Zhou, Zhaosheng Qian(Co-first author), Yanyan Ma, Yuanyuan Huang, Hui Feng*. A Universal Fluorometric Assay Strategy for Glycosidases Based on Functional Carbon Quantum Dots: ?-Galactosidase Activity Detection in vitro and in Living Cells.J. Mater. Chem. B,2017, 5, 1971-1979.
(31) Cong Tang, Zhaosheng Qian(Co-first author), Yinjie Qian, Yuanyuan Huang, Meizhi Zhao, Hang Ao, Hui Feng*. A Fluorometric and Real-time Assay for α-Glucosidase Activity Through Supramolecular Self-assembly and Its Application for Inhibitor Screening.Sens. Actuat. B-Chem,2017, 245, 282-289.
(32) Hong Huang, Hua Li, Jiuju Feng, Hui Feng, Aijun Wang,* Zhaosheng Qian.* One-pot green synthesis of highly fluorescent glutathione-stabilized copper nanoclusters for Fe³⁺sensing. Sens. Actuat. B Chem.2017, 241, 292-297.
(33) Yuanyuan Huang,Hui Feng, Weidong Liu, Yingying Zhou, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen,Zhaosheng Qian*. Luminescent aggregated copper nanoclusters nanoswitch controlled by hydrophobic interaction for real-time monitoring of acid phosphatatse activity.Anal. Chem.,2016, 88, 11575-11583.
(34) Fengqi Zhou,Hui Feng, Yafen Fang, Qian Sun,Zhaosheng Qian*. Phenylsulfonic acid functionalized carbon quantum dots based on biosensor for acetylcholinesterase activity monitoring and inhibitor screening.RSC Adv.,2016, 6, 105454-105460.
(35) Yuanyuan Huang, Jin Zhou,Hui Feng, Jieyu Zheng, Hui-Min Ma, Weidong Liu, Cong Tang, Hang Ao, Meizhi Zhao, Zhaosheng Qian*. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots.Biosens. Bioelectron.,2016,86, 748-755.
(36) Hang Ao, Zhaosheng Qian, Yuyu Zhu, Meizhi Zhao, Cong Tang, Yuanyuan Huang, Hui Feng,* Aijun Wang. A fluorometric biosensor based on functional Au/Agnanoclusters for real-time monitoring of tyrosinase activity. Biosens. Bioelectron., 2016, 83, 542-547.
(37) Cong Tang, Zhaosheng Qian, Yuanyuan Huang, Jiamin Xu, Hang Ao, Meizhi Zhao, Jin Zhou, Jianrong Chen, Hui Feng.* A fluorometric assay for alkaline phosphatase activity based on beta-cyclodextrin-modified carbon quantum dots through host-guest recognition. Biosens. Bioelectron., 2016, 83,274-280.
(38) Yuanyuan Huang, Weidong Liu, Hui Feng,Yangting Ye, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian.* Luminiescent nanoswitch based on organic-phase copper nanoclusters for sensitive detection of trace amount of water in organic solvents. Anal. Chem., 2016, 88, 7429-7434.
http://www.x-mol.com/news/3512
(39) Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* A fluorometric assay for acetylcholinesterase activity and inhibitor screening with carbon quantum dots. Sens. Actuators B: Chemical, 2016, 222, 879-886.
(40) Lujing Chai, Jin Zhou, Hui Feng, CongTang, Yuanyuan Huang, Zhaosheng Qian.* Functionalized carbonquantum dots with dopamine for tyrosinase activity monitoring and inhibitor screening: in vitro and intracellular investigation. ACS Appl. Mater. Interfaces, 2015, 7, 23564-23574.
(41) Lujing Chai, Jin Zhou, Hui Feng,Jingjing Lin, Zhaosheng Qian.* A reversible fluorescence nanoswitch based carbon quantum dots nanoassembly for detection of pyrophosphate ion. Sens. Actuators B: Chemical, 2015, 220, 138-145.
(42) Zhaosheng Qian, Lujing Chai, Qian Zhou, Yuanyuan Huang, Cong Tang, Jianrong Chen, Hui Feng.* Reversible fluorescent nanoswitch based on carbon quantum dots nanoassembly for real-time acid phosphatase activity monitoring. Anal. Chem.,2015, 87, 7332-7339.
(43) Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* Carbon quantum dots-based recyclable real-time fluorescence assay for alkaline phosphatase with adenosine triphosphate as substrate. Anal. Chem., 2015, 87, 2966-2973.
(44) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* A fluorescent nanosensor based on graphene quantum dots-aptamer probe and graphene oxide for detection of lead(II) ion. Biosens. Bioelectron., 2015, 68, 225-230.
(45) Zhaosheng Qian, Lujing Chai, Yuanyuan Huang, Cong Tang, Jiajia Shen, Jianrong Chen, Hui Feng.* A real-time fluorescent assay for the detection of alkaline phosphatase activity based on carbon quantum dots. Biosens. Bioelectron., 2015, 68, 675-680.
(46) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Simultaneous detection of multiple DNA targets by integrating dual-color graphenequantum dots nanoprobes and carbon nanotubes. Chem. Eur. J.,2014, 20, 16065-16069.
(47) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Dual-colored graphene quantum dots-labeled nanoprobes/graphene oxide: functional carbon materials for respective and simultaneous detection of DNA and thrombin. Nanotechnology,2014, 25, 415501.
This paper was selected as IOPselect articleby the journal. The Nanotechnology Lab Talk on this work is available athttp://nanotechweb.org/cws/article/lab/58679.
(48) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* DNA nanosensor based on biocompatible graphene quantum dots and carbon nanotubes. Biosens. Bioelectron., 2014, 60, 64-70.
(49) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* Si-doped carbon quantum dots: a facile and general preparation strategy, bioimaging application, and multifunctional sensor. ACS Appl. Mater. & Interfaces,2014, 6, 6797-6805.(Highly cited paper)
(50) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* A universal fluorescence sensing strategy based on biocompatible graphene quantum dots and graphene oxide for detection of DNA. Nanoscale, 2014, 6, 5671-5674.
(51) Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Zhaosheng Qian, Jianrong Chen, Hui Feng.* B-doped carbon quantum dots as a sensitive fluorescence probe for hydrogen peroxide and glucose detection. Analyst, 2014, 139, 2322-2325.
(52) Jin Zhou, Xiaoyue Shan, Juanjuan Ma, Yamin Gu, Zhaosheng Qian, Jianrong Chen, Hui Feng.*Facile synthesis of P-doped carbon quantum dots with highly efficient photoluminescence. RSC Adv., 2014, 4, 5465-5468.
(53) Zhaosheng Qian,* Juanjuan Ma, Xiaoyue Shan, Hui Feng, Linxiang Shao, Jianrong Chen. Highly luminescent N-doped carbon quantum dots as an effectivemultifunctional fluorescence sensing platform. Chem. Eur. J., 2014, 29, 2254-2263.(Highly cited paper)
(54) Zhaosheng Qian, Juanjuan Ma, Xiaoyue Shan, Linxiang Shao, Jin Zhou, Jianrong Chen, Hui Feng.* Surface functionalization of graphene quantum dots with small organic molecules from photoluminescence modulation to bioimaging applications: an experimental and theoretical investigation. RSC Adv., 2013,3, 14571-14579.
(55) JinZhou, Pei Lin, Juanjuan Ma, Xiaoyue Shan, Hui Feng,* Congcong Chen, Jianrong Chen, Zhaosheng Qian.*Facile synthesis of halogenated carbon quantum dots as an important intermediate for surface modification. RSC Adv., 2013, 3, 9625-9628.
(56) Zhaosheng Qian, Jin Zhou, Juanjuan Ma, Xiaoyue Shan, Congcong Chen, Jianrong Chen, Hui Feng.* The visible photoluminescence mechanism of oxidized multi-walled carbon nanotubes: an experimental and theoretical investigation. J. Mater. Chem. C, 2013, 22, 22113-22119.
(57) Zhaosheng Qian, Juanjuan Ma, Jin Zhou, Pei Lin, Congcong Chen, Jianrong Chen, Hui Feng.*Facile synthesis of halogenated multi-walled carbon nanotubes and their unusual photoluminescence. J. Mater. Chem., 2012, 22,22113-22119.
(58) Zhaosheng Qian*, Chen Wang, Gaohui Du, Jin Zhou, Congcong Chen, Juanjuan Ma, Jianrong Chen, Hui Feng. Multicolour fluorescent graphene oxide by cutting carbon nanotubes upon oxidation. CrystEngComm, 2012, 14,4976-4979.
(59) JinZhou, Chen Wang, Zhaosheng Qian*, Congcong Chen, Juanjuan Ma, Gaohui Du, Jianrong Chen, Hui Feng. Highly efficient fluorescentmulti-walled carbon nanotubes functionalized with diamines and amides. J. Mater. Chem., 2012, 22, 11912-11914.
(60) Zhaosheng Qian*, Congcongchen, Jianrong Chen, Lichun Kong, Chen Wang, Jin Zhou, Hui Feng. Unusual visible luminescence of aluminium polyoxocations in aqueous solution. Chem. Commun., 2011, 47, 12652-12654.
(61) Zhaosheng Qian*, Jin Zhou, Jianrong Chen, Chen Wang, Congcong Chen, Hui Feng. Nanosized N-dopedgraphene oxide with visible fluorescence in water for metal ions sensing. J. Mater. Chem., 2011, 21, 17635-17637.
(62) Zhaosheng Qian*, Chen Wang, Hui Feng, Congcong Chen, Jin Zhou, Jianrong Chen. Welldispersed single-walled carbon nanotubes with strong visiblefluorescence in water for metal ions sensing. Chem. Commun., 2011, 47, 7167-7169.
联系方式
E-mail：fenghui@zjnu.cn
实验室：浙江师范大学11-304室
通讯地址：浙江省金华市迎宾大道688号浙江师范大学生化学院
邮　　编：321004