浙江农林大学动物科技学院导师教师师资介绍简介-浙江农林大学

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段星博士/教授
段星，特设教授，主要从事哺乳动物卵母细胞成熟和早期胚胎发育调控的分子机理、人类疾病大动物猪模型的研究。主要学术成果包括：（1）首次提出线粒体在启动纺锤体迁移中的作用并阐明调控卵母细胞成熟的机制；（2）发现卵母细胞成熟过程中调控不均等分裂的分子网络和信号通路；（3）揭示染色体信号调控卵母细胞成熟和染色体倍性的分子机制。（4）解析影响卵子成熟的环境因素，在Nature Communications、EMBO J、Science Advances等国际权威期刊发表SCI论文28篇，他人引用次数超过600次。欢迎热爱科研，有学术追求的同学来实验室做毕业论文和报考本实验室研究生！

通讯地址
教育背景
工作经历
学术兼职
课程教学
获奖荣誉
研究方向
科研项目
发表论文

通讯地址浙江省杭州市临安区武肃街666号学2-507
邮编：311300
E-mail:duanxing@zafu.edu.cn
电话/传真：

教育背景博士(2012/09-2016/12): 南京农业大学，动物遗传育种与繁殖专业

学士(2008/09-2012/06): 山西农业大学，动物科学专业

工作经历 2020/06 - 至今：浙江农林大学动物科技学院特设教授

2017/02 - 2020/04：美国约翰·霍普金斯大学医学院博士后

学术兼职担任Biology of Reproduction、Cell Cycle、Journal of Cellular Physiology、Aging、Plos One、Peer J期刊审稿人。

课程教学遗传学（本科生）

获奖荣誉 1.浙江农林大学青年英才培养人选（2020）

2.浙江农林大学海外优青（2020）

3. 校优秀博士毕业论文（2018年，南京农业大学）

4. 校长奖学金（2016年，南京农业大学）

5. 第十届亚洲生殖生物技术学大会（ARBS）优秀海报奖（2013年）

研究方向 1. 卵母细胞成熟和胚胎发育的分子调控机理

2. 母源环境/环境内分泌干扰物影响卵母细胞质量及子代健康的机制研究

3. 人类疾病大动物模型构建

科研项目 1.国家自然科学基金青年基金项目（2021-2023）

2.浙江省属高校基本科研业务费专项资金（2021-2023）

3.浙江农林大学海外优秀青年人才启动经费（2020-2025）

发表论文 1.Duan X, Li YZ, Yi KX, Sun Sean, Li Rong*. Dynamic Organelle Distribution Initiates Actin-Based Spindle Migration in Mouse Oocytes. Nat Commun. 2020 Jan 14;11(1):277. doi.org/10.1038/s41467-019-14068-3. (IF: 11.878).

2.David Drutovic#, Duan X#, Li Rong, Petr Kalab*, Petr Solc*. RanGTP and importin b regulate meiosis I spindle assembly and function in mouse oocytes. EMBO J. 2020 Jan 2;39(1):e101689. doi: 10.15252/embj. (共一) (IF: 11.227)

3.Duan X, Sun SC. Actin cytoskeleton dynamics in mammalian oocyte meiosis. Biol Reprod. 2019, 100(1):15-24. (IF: 2.96)

4.Duan X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6 modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte meiosis. Biochim Biophys Acta Mol Cell Res. 2018, 1865(2):455-462. (IF: 4.739)

5.Duan X, Zhang Y, Chen KL, Zhang HL, Wu LL, Liu HL, Wang ZB, Sun SC*. The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis. J Cell Physiol. 2018, 233(8):6088-6097. (IF: 4.522)

6.Duan X, Zhang HL, Wu LL, Liu MY, Pan MH, Ou XH, Sun SC*. Involvement of LIMK1/2 in actin assembly during mouse embryo development. Cell Cycle. 2018, 17(11):1381-1389. (IF: 3.259)

7.Duan X, Liu J, Zhu CC, Wang QC, Cui XS, Kim NH, Xiong B, Sun SC*. RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis. Cell Cycle. 2016, 15(3):471-477. (IF: 3.259)

8.Duan X, Wang T, Dai XX, Liu HL, Sun SC*. Melamine negatively affects oocyte architecture, oocyte development and fertility in mice. Hum Reprod. 2015, 30(7):1643-1652. (IF: 5.506) (TOP, 一区)

9.Duan X, Wang QC, Chen KL, Zhu CC, Liu J, Sun SC*. Acrylamide effects on mouse oocyte quality and fertility in vivo. Sci Rep. 2015, 5:11562. (IF: 4.011)

10.Duan X, Chen KL, Zhang Y, Cui XS, Kim NH, Sun SC*. ROCK inhibition prevents mouse early embryo development. Histochem Cell Biol. 2014, 142(2):227-233. (IF: 2.64) (TOP, 一区)

11.Duan X, Liu J, Dai XX, Liu HL, Cui XS, Kim NH, Wang ZB, Wang Q, Sun SC*. Rho-GTPase Effector ROCK Phosphorylates Cofilin in Actin-Meditated Cytokinesis During Mouse Oocyte Meiosis. Biol Reprod. 2014, 90(2):37. (IF: 2.96)

12.Wang H, Li Y, Yang J, Duan X, Kalab P, Sun SX, Li R. Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes. Sci Adv. 2020 Apr 3;6(14):eaaz5004.

13.Yang J, Duan X, Fraser AK, Choudhury MI, Ewald AJ, Li R, Sun SX. Microscale pressure measurements based on an immiscible fluid/fluid interface. Sci Rep. 2019 Dec 27;9(1):20044.

14.Liu J, Wang QC, Duan X, Kim NH, Zhang Y, Sun SC*. Profilin 1 plays feedback role in actin-mediated polar body extrusion in mouse oocytes. Reprod Fertil Dev. 2018, 30(5):752-758.

15.Pan MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC*. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. J Cell Physiol. 2018, 233(3):2270-2278. 4.522

16.Wang T, Han J, Duan X, Xiong B, Cui XS, Kim NH, Liu HL, Sun SC*. The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro. Oncotarget. 2016,31;7(22):32554-65.

17.Hou YJ, Zhu CC, Duan X, Liu HL, Wang Q, Sun SC*. Both diet and gene mutation induced obesity affect oocyte quality in mice. Sci Rep. 2016, 6:18858. 4.011

18.Zhu CC, Zhang Y, Duan X, Han J, Sun SC*. The effects of HT-2 on mouse oocytes and its possible mechanisms. Arch Toxicol. 2015, 90(6):1495-1505. 6

19.Wang F, Zhang L, Duan X, Zhang GL, Wang ZB, Wang Q, Xiong B, Sun SC*. RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis. Cell Cycle. 2015, 14(17):2835-2843. 3.259

20.Dai XX, Duan X, Cui XS, Kim NH, Xiong B, Sun SC*. Melamine Induces Oxidative Stress in Mouse Ovary. PLoS One. 2015, 10(11):e**. 2.8

21.Wang QC, Liu J, Duan X, Cui XS, Kim NH, Xiong B, Sun SC*. Dynamin 2 inhibitor Dynasore affects actin filament distribution during mouse early embryo development. J Reprod Dev. 2015, 61(1):49-53. 2

22.Zhang Y, Duan X, Cao R, Liu HL, Cui XS, Kim NH, Rui R, Sun SC*. Small GTPase RhoA regulates cytoskeleton dynamics during porcine oocyte maturation and early embryo. Cell Cycle 2014, 13(21):3390-3403. 3.259

23.Zhang Y, Duan X, Xiong B, Cui XS, Kim NH, Rui R, Sun SC*. ROCK inhibitor Y-27632 prevents porcine oocyte maturation. Theriogenology. 2014, 82(1):49-56. 1.5

24.Wang QC, Liu J, Wang ZB, Zhang Y, Duan X, Cui XS, Kim NH, Sun SC*. Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes. Biol Cell. 2014, 106(6):193-202. 2.5

25.Dai XX, Duan X, Liu HL, Cui XS, Kim NH, Sun SC*. Chk2 regulates cell cycle progression during mouse oocyte maturation and early embryo development. Mol Cells. 2014, 37(2):126-132. 2.0

26.Hou YJ, Xiong B, Zheng WJ, Duan X, Cui XS, Kim NH, Wang Q, Xu YX, Sun SC*. Oocyte quality in mice is ?affected by a mycotoxin-contaminated diet. Environ Mol Mutagen. 2014 May;55(4):354-62. 2

27.Wang QC, Liu J, Wang F, Duan X, Dai XX, Wang T, Liu HL, Cui XS, Kim NH, Sun SC*. Role of nucleation-promoting factors in mouse early embryo development. Microsc Microanal. 2013, 19(3):559-564. 2

28.Liu J, Wang QC, Wang F, Duan X, Dai XX, Wang T, Liu HL, Cui XS, Kim NH, Sun SC*. Nucleation promoting factors regulate Arp2/3 complex in meiotic mouse oocyte. PLoS One. 2012, e52277. 2.8