刘明启
sex
1
title
副教授
department
生命科学学院
college

college2

degree
博士
recruit":0,"firstDiscipline1
生物学
secondaryDiscipline1

firstDiscipline2
药学
secondaryDiscipline2

executive

officePhone

mobilePhone
**
emailAddress
mqliu524@163.com
businessAddress
天问楼326
individualResume
刘明启（1978.12-），男，博士，副教授。2007年毕业于浙江大学，同年进入中国计量大学生命科学学院工作，主要从事酶工程、食品科学相关的教学和科研。\r 近年来，主要开展木聚糖酶定向进化、酶-抑制蛋白互作与分子模拟计算、新型固定化酶等相关研究,主持国家自然科学基金和浙江省自然科学基金共计6项，发表论文20多篇。
researchTopic
主持在研课题：\r1. 水稻XIP型抑制蛋白对11家族内切木聚糖酶催化活性的抑制作用及其机制研究（2017-2020），国家自然科学基金\r2. 低分子果胶的酶法制备及其抑制肝癌细胞增殖的分子机制研究（2019-2021），浙江省自然科学基金\r\r
awards
2020年，全国大学生生命科学竞赛二等奖，浙江省大学生生命科学竞赛二等奖，指导教师\r2020年，研究生国家奖学金，研究生导师\r2018年，研究生国家奖学金，研究生导师\r2018年，浙江省大学生生命科学竞赛二等奖，指导教师\r2017年，全国大学生生命科学竞赛三等奖，浙江省大学生生命科学竞赛二等奖，指导教师\r2016年，中国计量大学“学生最喜爱的老师”\r2015年，研究生国家奖学金，研究生导师\r2009年、2014年、2015年、2016年，浙江省大学生生命科学竞赛三等奖，指导教师\r2012年，中国计量学院优秀班主任。
researchProject
1. RIXI抑制蛋白对木聚糖酶的抑制作用及机制研究（2015-2017），浙江省自然科学基金\r2. 基于定向进化的木聚糖酶热稳定和催化活性研究（2013－2015）, 国家自然科学基金\r3. 聚半乳糖醛酸酶的高效重组表达及固定化研究（2010－2011），浙江省自然科学基金\r4. 木聚糖酶定向进化及热稳定性研究（2009－2010），浙江省教育厅项目\r5. 基于新型酶膜反应器的低分子果胶创制关键技术开发及应用（2012－2013），浙江省科技计划项目\r6. 新型饲料添加剂－果胶低聚糖创制关键技术（2011－2013），杭州市科技计划项目\r
publications
近年以第一作者、通讯作者发表的论文\r1.Laboratory Evolution of GH11 Endoxylanase Through DNA Shuffling: Effects of Distal Residue Substitution on Catalytic Activity and Active Site Architecture, 2019,Frontiers in Bioengineering and biotechonogy\r2.Differential inhibition of GH family 11 endo-xylanase by rice xylanase inhibitor and verification by a modified yeast two-hybrid system, 2019,International Journal of Biological Macromolecules.\r3.Recombinant rice xylanase-inhibiting protein inhibits GH11 endo-xylanases\rthrough competitive inhibition, 2019, Protein Expression and Purification.\r4.Inhibiting the Catalytic Activity of Family GH11 Xylanases by Recombinant Rice Xylanase-Inhibiting Protein, 2018, Catalysis Letters.\r5.Recombinant rice xylanase inhibitor (RIXI) expressed in Escherichia coli and its inhibitory activity on family GH11 endo-xylanases,2018,International Journal of Biological Macromolecules.\r6.Preparation of low-molecular-weight citrus pectin by recombinant Bacillus subtilis pectate lyase and promotion of growth of Bifidobacterium longum, 2018,Catalysis Communications.\r7.Recombinant Bacillus amyloliquefaciens xylanase A expressed in Pichia pastoris and generation of xylooligosaccharides from xylans and wheat bran,2017,International Journal of Biological Macromolecules.\r8. Recombinant thermostable Thermomonospora fusca TF endo-xylanase A and its immobilization on modified mesoporous SiO2 microspheres for manufacturing xylooligosaccharides,2017,Catalysis Letters.\r9. Obtaining a mutant of Bacillus amyloliquefaciens xylanase A with improved catalytic activity by directed evolution, Enzyme and Microbial Technology, 2016, 86: 59-66.\r10.Expression of recombinant Bacillus amyloliquefaciens xylanase A in Escherichia coli and potential application in Xylan hydrolysis, BioResources, 2015, 10(3): 4694-4710.\r11. An immobilized bifunctional xylanase on carbon-coated chitosan nanoparticles with a potential application in xylan-rich biomass bioconversion, Journal of Molecular Catalysis B: Enzymatic, 2015, 120: 119-126.\r12.Immobilization of Aspergillus niger xylanase A on Fe3O4-coated chitosan magnetic nanoparticles for xylooligosaccharides preparation, 2014, Catalysis Communications.\r13. Cloning, expression of Aspergillus niger JL-15 endo-polygalacturonase A gene in Pichia pastoris and oligo-galacturonates production,2014, Protein Expression and Purification.\r14. Obtaining cellulose binding and hydrolyzing activity of a family 11 hybrid xylanase by fusion with xylan binding domain. 2013, Protein Expression and Purification.\r15. Optimization of Solid-state fermentation for acidophilic pectinase production by Aspergillus niger JL-15 using response surface methodology and oligo-galacturonates preparation. 2012, American Journal of Food Technology.\r16. Optimization of xylanase production by Trichoderma reesei Jl-1 using response surface methodology and the enzymatic properties. 2011, Applied Mechanics and Mechanical Engineering II .\rOptimization of solid-state fermentation of Aspergillus niger Jl-15 for xylanase production and xylooligosaccharides preparation. 2011, Czech Journal of Food Science.\r17. Expression of recombinant Bacillus licheniformis xylanase A in Pichia pastoris and xylooligosaccharides released from xylans by it. 2008, Protein Expression and Purification.
others
计划招收生物学，药学研究生。研究经费充足，欢迎报考！
correlation
researchDirection1
酶工程
researchDirection2
海洋食品新资源
researchDirection3
食品安全
researchDirection4