许可博士
研究方向
主要从事生物医用材料与再生医学方面研究，在皮肤创面修复、脊髓损伤和脑损伤等领域积累了丰富经验，重点关注创伤修复中自噬和内质网应激的分子机制，针对创伤修复中血管新生问题开展大量基础研究工作。同时针对组织工程与皮肤修复方面开展来了医学转化工作。以第一作者或通讯作者发表SCI论文近10篇，专利一篇，主持国家自然科学基金青年项目一项，浙江省自然科学基金青年基金项目一项，以及浙江省药学重中之重项目一项。产品转化方面协助企业获得获得一类器械证三件，在批二类医疗器械一件。
基本信息
性别: 男 民族: 汉
出生年月: 1987年 10月
居住地: 浙江省温州市
电 话: **
E-Mail: godxu1987@163.com
科研项目
FGF2/PDGF 复合缓释水凝胶对创伤性脑损伤下自噬相关血脑屏障完整性及神经损伤修复的机制研究。浙江省基础公益青年基金项目，LQ18H150003，第一负责人，2018.1-2020.12，10万元。
bFGF/VEGF复合凝胶对创面修复的研究。浙江省药学重中之重学科开放基金项目，YKFJ3-011，第一负责人，2017.1-2018.12，8万元。
bFGF/PDGF复合水凝胶经PLCγ-AKT信号协同促脊髓损伤修复的研究。国家自然科学基金青年基金项目，**，第一负责人，2019.1-2021.12，21万元。
靶向胆汁淤积症的非促分裂型FGF19突变体的设计与开发，浙江省公益技术研究计划项目，LGF19H300004，核心成员，排名2/5，2019.1-2021.12，10万元。
高糖对脊髓损伤修复的影响及糖尿病合并脊髓损伤治疗的研究。国家自然科学基金青年基金项目，**，核心成员，排名3/10，2019.1-2021.12，21万元。
发表论文
第一作者或通讯作者论文
Wu F, Xu K, Xu K, et al. Dl-3n-butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis[J]. Journal of Cellular and Molecular Medicine, 2019.DOI:10.1111/jcmm.14691.(Co-first author, IF=4.658)
Xu K, An N, Zhang H, et al. Sustained-release of PDGF from PLGA microsphere embedded thermo-sensitive hydrogel promoting wound healing by inhibiting autophagy[J]. Journal of Drug Delivery Science and Technology, 2019: 101405. (First author, IF=2.606)
Wu F, Xu K, Liu L, et al. Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery after Traumatic Brain Injury by Inhibiting ER Stress-Induced neuron injury[J]. Frontiers in pharmacology, 2019, 10. (Co-first author, IF=3.845)
Xu K, Wang J L, Chu M P, et al. Activity of coumarin against Candida albicans biofilms[J]. Journal de mycologie medicale, 2019, 29(1): 28-34. (First author, IF=1.479)
Xu K, Zhu C, Xie J, et al. Enhanced vascularization of PCL porous scaffolds through VEGF-Fc modification[J]. Journal of Materials Chemistry B, 2018, 6(27): 4474-4485.(First author, IF=5.047)
Xu K, Shuai Q, Li X, et al. Human VE-cadherin fusion protein as an artificial extracellular matrix enhancing the proliferation and differentiation functions of endothelial cell[J]. Biomacromolecules, 2016, 17(3): 756-766. (First author, IF=5.667)
Xu K, Dai X L, Huang H C, et al. Targeting HDACs: a promising therapy for Alzheimer's disease[J]. Oxidative medicine and cellular longevity, 2011, 2011. (First author, IF=4.868)
许可, 姜招峰. 组蛋白去乙酰化酶 6 与阿尔兹海默病[J]. 生命的化学, 2011, 31(5): 667-670. (第一作者)
张海娟, 章琪露, 徐颖, 徐莉菲, 金柳君, 许可. (2019). 透明质酸锌的合成及在小鼠创面修复中的应用[J]. 温州医科大学学报, 2019 (1): 10.（通讯作者）
非第一作者或通讯作者论文
Zheng Z, Zhou Y, Ye L, Lu Q, Zhou K, Zhang J, Xie L, Wu Y, Xu K, Zhang H, Xiao J. Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury[J]. Experimental Neurology, 2019: 113138.
Wu Y, Li Y, Jiang T, Yuan Y, Li R, Xu Z, Zhong X, Jia G, Liu Y, Xie L, Xu K, Zhang H, Li X, Xiao J. Reduction of cellular stress is essential for Fibroblast growth factor 1 treatment for diabetic nephropathy[J]. Journal of cellular and molecular medicine, 2018, 22(12): 6294-6303.
Wang Q, Cai H, Hu Z, Wu Y, Guo X, Li J, Wang H, Liu Y, Liu Y, Xie L, Xu K, Xu H, He H, Zhang H, Xiao J. Loureirin B Promotes Axon Regeneration by Inhibiting Endoplasmic Reticulum Stress: Induced Mitochondrial Dysfunction and Regulating the Akt/GSK-3β Pathway after Spinal Cord Injury[J]. Journal of neurotrauma, 2019, 36(12): 1949-1964.
Li Y, Han W, Wu Y, Zhou K, Zheng Z, Wang H, Xie L, Li R, Xu K, Wang X, Xiao J. Stabilization of HIF-1α by DMOG promotes the recovery of acute spinal cord injury by inhibiting neural apoptosis and enhancing axon regeneration[J]. Journal of neurotrauma, 2019 (ja).
Zhong X, Wang B, Zhang G, Yuan Y, Hu X, Xiong J, Zheng P, Liu Y, Xu K, Xiao J, Wu Y, Ye J. Autophagy activation is involved in acidic fibroblast growth factor ameliorating Parkinson's disease via regulating tribbles homologue 3[J]. Frontiers in Pharmacology, 2019, 10: 1428.
Zheng Z, Wang Z G, Chen Y, Chen J, Khor Sinan, Li J, He Z, Wang Q, Zhang H, Xu K, Gong F, Xiao J, Wang X. Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration[J]. Journal of cellular and molecular medicine, 2018, 22(6): 3086-3096.
Wu Y, Ye L, Yuan Y, Jiang T, Guo X, Wang Z, Xu K, Xu Z, Liu Y, Zhong X, Ye J, Zhang H, Li X, Xiao J. Autophagy Activation is Associated with Neuroprotection in Diabetes-associated Cognitive Decline[J]. Aging and disease, 2019: 0.
Jia C, Zhang J, Zhuge Y, Xu K, Liu J, Wang J, Li L, Chu M. Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B[J]. Free radical research, 2019: 1-11.
Yang Y, Wang C, Zhuge Y, Zhan J, Xu K, Zhang Q, Zhang H, Chen H, Chu M, Jia C. Photodynamic antifungal activity of hypocrellin A against Candida albicans[J]. Frontiers in microbiology, 2019, 10: 1810.
Ye Q, Wu Y, Wu J, Zou S, Al-Zaazaai A.A, Zhang H, Shi H, Xie L, Liu Y, Xu K, He H, Zhang F, Ji Y, He Y, Xiao J. Neural Stem Cells Expressing bFGF Reduce Brain Damage and Restore Sensorimotor Function after Neonatal Hypoxia-Ischemia[J]. Cellular Physiology and Biochemistry, 2018, 45(1): 108-118.
Jia C, Zhang J, Yu L, Wang C, Yang Y, Rong X, Xu K, Chu M. Antifungal activity of coumarin against Candida albicans is related to apoptosis[J]. Frontiers in cellular and infection microbiology, 2018, 8: 445.
Li R, Wu Y, Zou S, Wang X, Li Y, Xu K, Gong F, Liu Y, Wang J, Liao Y, Li X, Xiao J. NGF attenuates high glucose-induced ER stress, preventing Schwann cell apoptosis by activating the PI3K/AKT/GSK3β and ERK1/2 pathways[J]. Neurochemical research, 2017, 42(11): 3005-3018.
Xu N, Deng W, He G, Gan X, Gao S, Chen Y, Gao Y, Xu K, Qi J, Lin H, Shen L, Li X, Hu Z. Alpha-and gamma-mangostins exhibit anti-acne activities via multiple mechanisms[J]. Immunopharmacology and immunotoxicology, 2018, 40(5): 415-422.
Li R, Li Y, Wu Y, Zhao Y, Chen H, Yuan Y, Xu K, Zhang H, Lu Y, Wang J, Li X, Jia X, Xiao J. Heparin-poloxamer thermosensitive hydrogel loaded with bFGF and NGF enhances peripheral nerve regeneration in diabetic rats[J]. Biomaterials, 2018, 168: 24-37.
Zhang M, Wu Y Q, Xie L, Wu J, Xu K, Xiao J, Chen D. Isoliquiritigenin protects against pancreatic injury and intestinal dysfunction after severe acute pancreatitis via Nrf2 signaling[J]. Frontiers in pharmacology, 2018, 9.
Li R, Zou S, Wu Y, Li Y, Sinan Khor, Mao Y, He H, Xu k, Zhang H, Li X, Wang J, Jiang H, Jin Q, Ye Q, Ye Q, Wang Z, Xiao J. Heparin-based coacervate of bFGF facilitates peripheral nerve regeneration by inhibiting endoplasmic reticulum stress following sciatic nerve injury[J]. Oncotarget, 2017, 8(29): 48086.
Wu J, Chen A, Zhou Y, Zheng S, Yang Y, An Y, Xu K, He H, Kang J, Luckanagul J, Xiao M, Xiao J, Wang Q. Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages[J]. Biomaterials, 2019,
222: 119398.
Xu K, Wu F, Xu K, Li Z, Wei X, Lu Q, Jiang T, Wu F, Xu X, Xiao J, Chen D, Zhang H. NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K/Akt/mTOR signalling pathway to improve functional recovery after traumatic brain injury[J]. Chemico-biological interactions, 2018, 286: 96-105.
Wang H, Wu Y, Han W, Li J, Xu K, Li Z, Wang Q, Xu k, Liu Y, Xie L,Wu J, He H, Xu H, Xiao J. Hydrogen sulfide ameliorates blood-spinal cord barrier disruption and improves functional recovery by inhibiting endoplasmic reticulum stress-dependent autophagy[J]. Frontiers in pharmacology, 2018, 9: 858.
He N, Chen X, Wang D, Xu K, Wu L, Liu Y, Tao H, Zhao Q, Cao X, Li Y, Liu N, Qi X, Han Z, Kong D, Yang J, Li Z. VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway[J]. Biomaterials, 2018, 158: 34-43.
Huang H C, Tang D, Xu K, Jiang Z. Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway[J]. Journal of Receptors and Signal Transduction, 2014, 34(1): 26-37.
Huang H C, Xu K, Jiang Z F. Curcumin-mediated neuroprotection against amyloid-β-induced mitochondrial dysfunction involves the inhibition of GSK-3β[J]. Journal of Alzheimer's Disease, 2012, 32(4): 981-996.
申请专利
载PDGF微球的温敏壳聚糖水凝胶及其制备方法和应用，（申请号：4.1），发明专利，中国，2019. 10。（排名第一）
一种吸湿透气型伤口敷料贴，（授权号：ZL 9.8）发明专利，中国，2019.08。（排名第二）
一种复合生长因子促修复凝胶及其制备方法与应用，（申请号：5.0），发明专利，中国，2017. 11。（排名第三）
一种医用凝胶及其制备方法与应用，（申请号：7.7），发明专利，中国，2017. 11。（排名第三）
一种复合生长因子抗菌促修复凝胶及其制备方法与应用，（申请号：0.3），发明专利，中国，2017. 11。（排名第三）
人才奖项
纳米生物矿物质材料以及功能性口腔护理产品开发，河北省创新创业大赛一等奖，证书编号2019T001。








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