基本信息INFORMATION
李宝宗
联系方式 CONTACT
@qq.com
站点计数器SITE COUNTER

个人简介PERSONAL PROFILE
李宝宗，男， 1980年3月出生于湖北省云梦县，现为绍兴文理学院生命科学学院专任教师，武汉大学药学和工商管理双学士（2002），微生物学博士（医学病毒学，2007），美国莫菲特癌症中心（Tampa，FL）及希望之城（Los Angeles，CA）博士后，研究癌症信号通路及小分子药物筛选，后进入北美生物医学研究中心（Los Angeles，CA），药明康德（辉源生物）和中美冠科（San Diego，CA），从事免疫癌症及小鼠动物模型方面的研究工作。
教学工作 EXPERIENCE
《人类遗传与健康》
研究方向RESEARCH DIRECTION
免疫癌学
科研项目RESEARCH FIELD
开发实体瘤（如胰腺癌，乳腺癌）的免疫疗法，在细胞水平和小鼠模型中开展研究，探讨合理的用药剂量，给药途径，药动药代药效学特征，阐明药物抑制肿瘤生长的机理，为实体瘤的临床研究提供线索和依据。
研究成果RESEARCH FINDINGS
A Novel Class of HIV-1 Antiviral Agents Targeting HIV via a SUMOylation-Dependent Mechanism. Madu IG, Li S, Li B, Li H, et al. Sci Rep. 2015 Dec 8;5:17808
Sumoylation of SAE2 C terminus regulates SAE nuclear localization. Truong K, Lee TD, Li B, Chen Y. J Biol Chem. 2012 Dec 14;287(51):42611-9.
Abnormal MDMX degradation in tumor cells due to ARF deficiency. Li X, Gilkes D, Li B, Cheng Q, et al. Oncogene. 2012 Aug 9;31(32):3721-32.
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage. Cheng Q, Cross B, Li B, et al. Mol Cell Biol. 2011 Dec;31(24):4951-63.
Inhibition of p53 DNA binding function by the MDM2 protein acidic domain. Cross B, Chen L, Cheng Q, Li B, et al. J Biol Chem. 2011 May 6;286(18):16018-29.
p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors. Li B, Cheng Q, Li Z, Chen J. Cell Cycle. 2010 Apr 1;9(7):1411-20.
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. Phan J, Li Z, Kasprzak A, Li B, et al. J Biol Chem. 2010 Jan 15;285(3):2174-83
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. Kabra N, Li Z, Chen L, Li B, et al. J Biol Chem. 2009 Jul 3;284(27):18210-7.
Torque teno virus (SANBAN isolate) ORF2 protein suppresses NF-kappaB pathways via interaction with IkappaB kinases. Zheng H, Ye L, Fang X, Li B, et al. J Virol. 2007 Nov;81(21):11917-24.
The membrane protein of SARS-CoV suppresses NF-kappaB activation.Fang X, Gao J, Zheng H, Li B, et al. J Med Virol. 2007 Oct;79(10):1431-9.
Up-regulation of IL-6 and TNF-alpha induced by SARS-coronavirus spike protein in murine macrophages via NF-kappaB pathway. Wang W, Ye L, Ye L, Li B, et al. Virus Res. 2007 Sep;128(1-2):1-8.
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Li B, Gao B, Ye L, Han X, et al. Virus Res. 2007 Mar;124(1-2):44-9.
Expression, purification and characterization of the Hepatitis B virus entire envelope large protein in Pichia pastoris.Han X, Ye L, Li B, Bo G, et al. Protein Expr Purif. 2006 Oct;49(2):168-75.
Nucleocapsid amino acids 211 to 254, in particular, tetrad glutamines, are essential for the interaction between the nucleocapsid and membrane proteins of SARS-associated coronavirus. Fang X, Ye LB, Zhang Y, Li B, et al. J Microbiol. 2006 Oct;44(5):577-80.
荣誉奖励 HONOR AWARD
美国杰出人才（EB1 Extraordinary Ability， 2013）
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