基本信息INFORMATION
闫俊艳
联系方式 CONTACT
地址：6号综合楼B507
邮箱：jyyan2018@usx.edu.cn
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个人简介PERSONAL PROFILE
学习经历：
2014.9-2017.7，中国科学院苏州纳米技术与纳米仿生研究所，细胞生物学，博士
2010.9-2013.7，中国农业科学院研究生院，生物化学与分子生物学，硕士
2006.9-2010.7，武汉轻工大学，动物科学，本科
工作经历：
2018.5至今，绍兴文理学院，讲师，硕士生导师
2017.9-2018.4,江苏省血吸虫病防治研究所，科研人员
2013.7-2014.3，中国科学院微生物研究所，科研助理
教学工作 EXPERIENCE
主讲的课程：《微生物技术与应用》、《专业导论》、《药膳与养生》
研究方向RESEARCH DIRECTION
（1）纳米材料及环境污染物的生物毒理
目前纳米科技运用十分多元，人们可以通过注入纳米药物或长期暴露于纳米材料生产车间等途径，引发纳米安全性的困扰。因此，纳米安全性的研究将成为纳米科学领域所必须迫切关注的议题。另外，PM2.5环境问题日益凸显，PM2.5引发的肺部及心血管毒性机制尚不明确，亟待深入研究。
（2）干细胞示踪剂的研发及利用
针对目前干细胞移植在中枢神经损伤、肝衰竭、尘肺等重大疾病修复治疗中亟需的体内示踪要求，我们拟构建安全、高效的纳米示踪剂，实现对移植干细胞实时、高灵敏、高特异性的体外或体内示踪。
科研项目RESEARCH FIELD
不同粒径细颗粒物对人脐带间充质干细胞毒性及分化潜能的研究，主持，绍兴文理学院科研启动基金，2018.7~ 2020.7。
研究成果RESEARCH FINDINGS
（1）第一作者论文
1. Junyan Yan, Chih-Ching Huang, Shih-Chun Candice Lung, Wen-Cheng Wang, Guangli.Suo, Yu-Jing Lin, Chia-Hsiang Lai(*) and Chia-Hua Lin(*). ROCK inhibitor attenuated early atherosclerosis caused by occupational environmental concentrations of carbon black nanoparticles. Environmental Science: Nano, 2017; 4 (7),1525-1533 . (IF:6.087)
2. Junyan Yan(#), Chia-Hsiang Lai(#), Shih-Chun Candice Lung, Wen-Cheng Wang, Pin-I Huang, Chia-Hua Lin(*). Daily alveolar deposition dose of PM2.5 extracts cause pulmonary adverse effect through RhoA/ROCK pathway. Science of the Total Environment, 2017;599–600:1658–1666.( IF:4.610 )
3. Junyan Yan(#), Chia-Hsiang Lai(#), Shih-Chun Candice Lung, Wen-Cheng Wang, Chih-Ching Huang, Guan-Wen Chen, Guangli Suo, Cheng-Tai Choug, Chia-Hua Lin(*). Carbon black aggregates cause endothelial dysfunction by activating ROCK. Journal of Hazardous Materials, 2017;338: 66–75. (IF:6.434)
4. Junyan Yan, Liliang Chen, Chih-Ching Huang, Lingyan Yang, Wen-Cheng Wang, Po-Hsiung Lin, Guangli Suo(*) and Chia-Hua Lin(*). Consecutive evaluation of graphene oxide and reduced graphene oxide nanoplatelets immunotoxicity on monocytes. Colloids and Surfaces B Biointerfaces, 2017;153:300-309. (IF:3.997)
5. Junyan Yan(#), Shulan Hou(#), Yanzhen Yu, Yong Qiao, Tongqian Xiao, Yan Mei, Zhijun Zhang, Bin Wang, Chih-Ching Huang, Chia-Hua Lin(*) and Guangli Suo(*). The effect of surface charge on the cytotoxicity and uptake of carbon quantum dots in human umbilical cord derived mesenchymal stem cells. Colloids and Surfaces B Biointerfaces, 2018;171:241-249. (IF:3.997)
6. Junyan Yan, Qiao Y, Hu J, Ding HB(*). Cloning, expression and characterization of a trehalose synthase gene from Rhodococcus opacus. Protein J, 2013;32:223–229. (IF:1.133)
（2）通讯作者论文
Lifang Jin, Jian Ni, Yuan Tao, Xinyi Weng, Yuling Zhu, Junyan Yan(*) and Baowei Hu(*). N-acetylcysteine attenuates PM2.5-induced apoptosis by ROS-mediated Nrf2 pathway in human embryonic stem cells, Science of the Total Environment, 2019;666:713-720 ( IF:4.610 )
（3）既非第一作者又非通讯作者论文
Yi-Chun Chen, Saranta Sawettanun, Ku-Fan Chen, Chao-Yu Lee, Junyan Yan, Hung-Hsiang Chen, Guan-Wen Chen, Chia-Hua Lin(*). Enhanced Efficient NIR Photothermal Therapy Using Pleurocidin NRC-03 Peptide Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite. ACS Omega, 2019;4, 3298?3305.
Jiantao Yu, Yu-Hsin Lin, Lingyan Yang, Chih-Ching Huang, Liliang Chen, Wen-Cheng Wang, Guan-Wen Chen, Junyan Yan, Saranta Sawettanun, Chia-Hua Lin(*). Improved Anticancer Photothermal Therapy Using the Bystander Effect Enhanced by Antiarrhythmic Peptide Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite. Adv. Healthcare Mater,2017;6(2).
金立方，倪坚，闫俊艳，韩继卫，胡保卫(*)，Hedgehog信号通路对肝脏再生修复的研究进展, 接收。
乔宇，闫俊艳，常敏，丁宏标(*)，重组大肠杆菌产普鲁兰酶的高密度发酵工艺研究，生物技术进展，2012，2（3）：195-200。
乔宇，闫俊艳，王海燕，丁宏标(*)，一株普鲁兰酶产生菌的分离鉴定及发酵条件的优化，中国农业科技导报，2012，14（4）：81-86。
（4）参与编写的书目
Jiangtao Yu, Lingyan Yang, Junyan Yan, Wen-Cheng Wang, Yi-Chun Chen, Hung_Hsiang Chen, and Chia-Hua Lin(*). Carbon Nanomaterials for Photothermal Therapies. In book: Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy, Publisher: Wiley, 2019;324.
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